Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing [0.03%]
优势支配在哺乳动物中普遍存在，并与反式作用的基因表达和选择性拼接相关
Leilei Cui,Bin Yang,Shijun Xiao et al.
Leilei Cui et al.
Background: Dominance and other non-additive genetic effects arise from the interaction between alleles, and historically these phenomena play a major role in quantitative genetics. However, most genome-wide association s...
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial-temporal regulation of histone arginine methylation in neurodevelopment [0.03%]
人类Oxidation Resistance 1功能丧失突变破坏神经发育组蛋白精氨酸甲基化的时空调节
Xiaolin Lin,Wei Wang,Mingyi Yang et al.
Xiaolin Lin et al.
Background: Oxidation Resistance 1 (OXR1) gene is a highly conserved gene of the TLDc domain-containing family. OXR1 is involved in fundamental biological and cellular processes, including DNA damage response, antioxidant...
Pauline Trinh,David S Clausen,Amy D Willis
Pauline Trinh
Recovering metagenome-assembled genomes (MAGs) from shotgun sequencing data is an increasingly common task in microbiome studies, as MAGs provide deeper insight into the functional potential of both culturable and non-culturable microorgani...
Ruslan Deviatiiarov,Hiroki Nagai,Galym Ismagulov et al.
Ruslan Deviatiiarov et al.
In birds, sex is genetically determined; however, the molecular mechanism is not well-understood. The avian Z sex chromosome (chrZ) lacks whole chromosome inactivation, in contrast to the mammalian chrX. To investigate chrZ dosage compensat...
DISCERN: deep single-cell expression reconstruction for improved cell clustering and cell subtype and state detection [0.03%]
DISCERN：改进细胞聚类及细胞亚型和状态检测的深度单细胞转录组表达重构技术
Fabian Hausmann,Can Ergen,Robin Khatri et al.
Fabian Hausmann et al.
Background: Single-cell sequencing provides detailed insights into biological processes including cell differentiation and identity. While providing deep cell-specific information, the method suffers from technical constr...
Author Correction: Single-cell resolution analysis reveals the preparation for reprogramming the fate of stem cell niche in cotton lateral meristem [0.03%]
作者更正：单细胞分辨率分析揭示了棉花侧分生组织干细胞巢重塑的命运准备
Xiangqian Zhu,Zhongping Xu,Guanying Wang et al.
Xiangqian Zhu et al.
Published Erratum
Genome biology. 2023 Sep 18;24(1):210. DOI:10.1186/s13059-023-03051-3 2023
Disparities in spatially variable gene calling highlight the need for benchmarking spatial transcriptomics methods [0.03%]
空间可变基因呼叫的差异突显了对空间转录组学方法进行基准测试的需求
Natalie Charitakis,Agus Salim,Adam T Piers et al.
Natalie Charitakis et al.
Identifying spatially variable genes (SVGs) is a key step in the analysis of spatially resolved transcriptomics data. SVGs provide biological insights by defining transcriptomic differences within tissues, which was previously unachievable ...
Structural variation and introgression from wild populations in East Asian cattle genomes confer adaptation to local environment [0.03%]
东亚家牛基因组中的结构变异和来自野生群体的基因渗入使其适应当地环境
Xiaoting Xia,Fengwei Zhang,Shuang Li et al.
Xiaoting Xia et al.
Background: Structural variations (SVs) in individual genomes are major determinants of complex traits, including adaptability to environmental variables. The Mongolian and Hainan cattle breeds in East Asia are of taurine...
COLLAGENE enables privacy-aware federated and collaborative genomic data analysis [0.03%]
COLLAGENE实现隐私保护的联邦和协作基因组数据分析
Wentao Li,Miran Kim,Kai Zhang et al.
Wentao Li et al.
Growing regulatory requirements set barriers around genetic data sharing and collaborations. Moreover, existing privacy-aware paradigms are challenging to deploy in collaborative settings. We present COLLAGENE, a tool base for building secu...
Coupling of co-transcriptional splicing and 3' end Pol II pausing during termination in Arabidopsis [0.03%]
拟南芥中转录终止期间的协同转录剪接和Pol II在3'端的暂停耦合现象
Sixian Zhou,Fengli Zhao,Danling Zhu et al.
Sixian Zhou et al.
Background: In Arabidopsis, RNA Polymerase II (Pol II) often pauses within a few hundred base pairs downstream of the polyadenylation site, reflecting efficient transcriptional termination, but how such pausing is regulat...