Conservation and divergence of canonical and non-canonical imprinting in murids [0.03%]
鼠科动物经典和非经典印记的保守与分歧
Julien Richard Albert,Toshihiro Kobayashi,Azusa Inoue et al.
Julien Richard Albert et al.
Background: Genomic imprinting affects gene expression in a parent-of-origin manner and has a profound impact on complex traits including growth and behavior. While the rat is widely used to model human pathophysiology, f...
Meta-Analysis
Genome biology. 2023 Mar 14;24(1):48. DOI:10.1186/s13059-023-02869-1 2023
Cell-specific clock-controlled gene expression program regulates rhythmic fiber cell growth in cotton [0.03%]
棉纤维特异的时钟控制基因表达程序调控其周期性生长发育
Dehe Wang,Xiao Hu,Hanzhe Ye et al.
Dehe Wang et al.
Background: The epidermis of cotton ovule produces fibers, the most important natural cellulose source for the global textile industry. However, the molecular mechanism of fiber cell growth is still poorly understood. ...
The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection [0.03%]
SARS-CoV-2聚合酶（NSP12）中的P323L替代在感染过程中具有选择优势
Hannah Goldswain,Xiaofeng Dong,Rebekah Penrice-Randal et al.
Hannah Goldswain et al.
Background: The mutational landscape of SARS-CoV-2 varies at the dominant viral genome sequence and minor genomic variant population. During the COVID-19 pandemic, an early substitution in the genome was the D614G change ...
Extensive sequence duplication in Arabidopsis revealed by pseudo-heterozygosity [0.03%]
拟异交揭示模式植物中的序列复制现象
Benjamin Jaegle,Rahul Pisupati,Luz Mayela Soto-Jiménez et al.
Benjamin Jaegle et al.
Background: It is apparent that genomes harbor much structural variation that is largely undetected for technical reasons. Such variation can cause artifacts when short-read sequencing data are mapped to a reference genom...
Genetic mapping and molecular mechanism behind color variation in the Asian vine snake [0.03%]
亚洲藤蛇颜色变异的基因定位及其分子机制研究
Chen-Yang Tang,Xiaohu Zhang,Xiao Xu et al.
Chen-Yang Tang et al.
Background: Reptiles exhibit a wide variety of skin colors, which serve essential roles in survival and reproduction. However, the molecular basis of these conspicuous colors remains unresolved. ...
The Network Zoo: a multilingual package for the inference and analysis of gene regulatory networks [0.03%]
网络动物园：推断和分析基因调控网络的多语言软件包
Marouen Ben Guebila,Tian Wang,Camila M Lopes-Ramos et al.
Marouen Ben Guebila et al.
Inference and analysis of gene regulatory networks (GRNs) require software that integrates multi-omic data from various sources. The Network Zoo (netZoo; netzoo.github.io) is a collection of open-source methods to infer GRNs, conduct differ...
Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth [0.03%]
补体成分4变异与青年精神疾病和脑表型的多祖先表型全基因组关联研究
Leanna M Hernandez,Minsoo Kim,Pan Zhang et al.
Leanna M Hernandez et al.
Background: Increased expression of the complement component 4A (C4A) gene is associated with a greater lifetime risk of schizophrenia. In the brain, C4A is involved in synaptic pruning; yet, it remains unclear the extent...
Lisha Shen,Jinqi Ma,Ping Li et al.
Lisha Shen et al.
Chemical modifications of RNAs, known as the epitranscriptome, are emerging as widespread regulatory mechanisms underlying gene regulation. The field of epitranscriptomics advances recently due to improved transcriptome-wide sequencing stra...
SRTsim: spatial pattern preserving simulations for spatially resolved transcriptomics [0.03%]
SRTsim：空间转录组学的保真度和模式保留模拟工具
Jiaqiang Zhu,Lulu Shang,Xiang Zhou
Jiaqiang Zhu
Spatially resolved transcriptomics (SRT)-specific computational methods are often developed, tested, validated, and evaluated in silico using simulated data. Unfortunately, existing simulated SRT data are often poorly documented, hard to re...
Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation [0.03%]
MLL3/4丢失在胚胎干细胞分化过程中解除了增强子H3K4单甲基化、H3K27乙酰化和基因激活之间的关联
Ryan M Boileau,Kevin X Chen,Robert Blelloch
Ryan M Boileau
Background: Enhancers are essential in defining cell fates through the control of cell-type-specific gene expression. Enhancer activation is a multi-step process involving chromatin remodelers and histone modifiers includ...