Zeyang Shen,Lukian Robert,Milan Stolpman et al.
Zeyang Shen et al.
Background: Metagenome-assembled genomes have greatly expanded the reference genomes for skin microbiome. However, the current reference genomes are largely based on samples from adults in North America and lack represent...
Phytochromes transmit photoperiod information via the evening complex in Brachypodium [0.03%]
拟南芥PHYTOCHROMES通过evening复合体传导光周期信息
Mingjun Gao,Yunlong Lu,Feng Geng et al.
Mingjun Gao et al.
Background: Daylength is a key seasonal cue for animals and plants. In cereals, photoperiodic responses are a major adaptive trait, and alleles of clock genes such as PHOTOPERIOD1 (PPD1) and EARLY FLOWERING3 (ELF3) have b...
Author Correction: Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture [0.03%]
更正：由Dog10K联盟进行的2000只犬基因组测序促进了对人口统计，基因组功能和结构的理解
Jennifer R S Meadows,Jefrey M Kidd,Guo-Dong Wang et al.
Jennifer R S Meadows et al.
Published Erratum
Genome biology. 2023 Nov 7;24(1):255. DOI:10.1186/s13059-023-03101-w 2023
Georgi K Marinov,S Tansu Bagdatli,Tong Wu et al.
Georgi K Marinov et al.
Background: Archaea, together with Bacteria, represent the two main divisions of life on Earth, with many of the defining characteristics of the more complex eukaryotes tracing their origin to evolutionary innovations fir...
Lukas Theo Schmitt,Aksana Schneider,Jonas Posorski et al.
Lukas Theo Schmitt et al.
We introduce DEQSeq, a nanopore sequencing approach that rationalizes the selection of favorable genome editing enzymes from directed molecular evolution experiments. With the ability to capture full-length sequences, editing efficiencies, ...
In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation [0.03%]
类器官单细胞CRISPR筛选揭示肝细胞分化和成熟的决定因素
Junbo Liang,Jinsong Wei,Jun Cao et al.
Junbo Liang et al.
Background: Harnessing hepatocytes for basic research and regenerative medicine demands a complete understanding of the genetic determinants underlying hepatocyte differentiation and maturation. Single-cell CRISPR screens...
CHESS 3: an improved, comprehensive catalog of human genes and transcripts based on large-scale expression data, phylogenetic analysis, and protein structure [0.03%]
CHESS 3：基于大规模表达数据、谱系分析和蛋白质结构的改进型人类基因和转录本综合目录
Ales Varabyou,Markus J Sommer,Beril Erdogdu et al.
Ales Varabyou et al.
CHESS 3 represents an improved human gene catalog based on nearly 10,000 RNA-seq experiments across 54 body sites. It significantly improves current genome annotation by integrating the latest reference data and algorithms, machine learning...
Comparison of gene clustering criteria reveals intrinsic uncertainty in pangenome analyses [0.03%]
比较基因聚类标准揭示了泛基因组分析的内在不确定性
Saioa Manzano-Morales,Yang Liu,Sara González-Bodí et al.
Saioa Manzano-Morales et al.
Background: A key step for comparative genomics is to group open reading frames into functionally and evolutionarily meaningful gene clusters. Gene clustering is complicated by intraspecific duplications and horizontal ge...
MGA-seq: robust identification of extrachromosomal DNA and genetic variants using multiple genetic abnormality sequencing [0.03%]
MGA-seq：使用多重基因异常测序 robustly识别细胞遗传DNA和变异
Da Lin,Yanyan Zou,Xinyu Li et al.
Da Lin et al.
Genomic abnormalities are strongly associated with cancer and infertility. In this study, we develop a simple and efficient method - multiple genetic abnormality sequencing (MGA-Seq) - to simultaneously detect structural variation, copy num...
Landscape of enhancer disruption and functional screen in melanoma cells [0.03%]
黑色素瘤细胞中增强子破坏的景观及其功能筛选
Zhao Wang,Menghan Luo,Qian Liang et al.
Zhao Wang et al.
Background: The high mutation rate throughout the entire melanoma genome presents a major challenge in stratifying true driver events from the background mutations. Numerous recurrent non-coding alterations, such as those...