Heather J Zhou,Xinzhou Ge,Jingyi Jessica Li
Heather J Zhou
A central task in expression quantitative trait locus analysis is to identify cis-eGenes, i.e., genes whose expression levels are regulated by at least one local genetic variant. Existing cis-eGene identification methods are either computat...
The genomic footprints of migration: how ancient DNA reveals our history of mobility [0.03%]
遗传痕迹：古DNA揭示了我们迁徙的历史
Matthew P Williams,Christian D Huber
Matthew P Williams
Ancient DNA has emerged as a powerful tool for studying human migration through the detection of admixture signatures. Here, we present the theoretical principles and methodologies for admixture analysis, with an emphasis on f-statistics an...
ZSCAN4 functions as a safeguard to maintain centromere integrity during oocyte meiosis [0.03%]
ZSCAN4在卵子减数分裂过程中作为维持着丝粒完整性的保护因子发挥作用
Da Yi Choi,Jiyeon Leem,Crystal Lee et al.
Da Yi Choi et al.
Background: Centromeres play a vital role in ensuring accurate chromosome segregation during meiosis by serving as the foundation for kinetochore assembly and microtubule attachment. In oocytes, maintaining centromere int...
Ting Wu,Hang-Xu Zhou,Jing Tian et al.
Ting Wu et al.
Background: It is crucial to investigate protein functions in specific subcellular environments. Cross-linking mass spectrometry is a powerful tool to map the direct interactome of proteins by identifying inter-protein cr...
Evaluating the representational power of pre-trained DNA language models for regulatory genomics [0.03%]
评估预训练DNA语言模型在调控基因组学中表征能力的大小
Ziqi Tang,Nirali Somia,Yiyang Yu et al.
Ziqi Tang et al.
Background: The emergence of genomic language models (gLMs) offers an unsupervised approach to learning a wide diversity of cis-regulatory patterns in the non-coding genome without requiring labels of functional activity ...
G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer cells [0.03%]
G-四链体结构通过调控远程基因重编程促进卵巢癌细胞耐药性生成
Jenna Robinson,Gem Flint,Ian Garner et al.
Jenna Robinson et al.
Background: Epigenetic evolution is a common mechanism used by cancer cells to evade the therapeutic effects of drug treatment. In ovarian cancers, epigenetically driven resistance is thought to be responsible for many la...
DNA 5mC methylation inhibits the formation of G-quadruplex structures in the genome [0.03%]
DNA 5mC甲基化可抑制基因组中G-四链体的形成
Kangkang Niu,Lijun Xiang,Xiaojuan Zhang et al.
Kangkang Niu et al.
Background: G-quadruplex structures (G4s) have been identified in the genomes of many organisms and have been proven to play significant epigenetic regulatory roles in gene transcription. Intriguingly, only a small portio...
Admixed and single-continental genome segments of the same ancestry have distinct linkage disequilibrium patterns [0.03%]
杂交和单一大陆的同一祖先基因组片段具有不同的链锁不平衡模式
Hanbin Lee,Moo Hyuk Lee,Kangcheng Hou et al.
Hanbin Lee et al.
Background: Admixed populations offer valuable insight into the genetic architecture of complex traits. Many studies have proposed methods for genome-wide association study (GWAS) in admixed populations and various simula...
Protein quantitative trait locus analysis in African American and non-Hispanic White individuals [0.03%]
非洲裔美国人和非西班牙裔白人的蛋白质数量性状位点分析
Yanwei Cai,Mari Johnson,Jeffrey Haessler et al.
Yanwei Cai et al.
Background: Substantial efforts have been dedicated to exploring the link between genetic regulation and the proteome, informing studies of complex trait mechanisms. Most of these efforts have been limited to populations ...
T-DNAreader: fast and precise identification of T-DNA insertion sites in plant genomes using RNA sequencing data [0.03%]
基于RNA测序数据的植物基因组中T-DNA插入位点的快速精确定位工具T-DNA reader
Hongwoo Lee,Pil Joon Seo
Hongwoo Lee
Agrobacterium-mediated plant transformation, which enables the delivery of DNA using transfer DNA (T-DNA) binary vectors, is an essential technique in plant research. T-DNAs randomly integrate into the host genome, and multiple T-DNAs can s...