SQANTI-SIM: a simulator of controlled transcript novelty for lrRNA-seq benchmark [0.03%]
SQANTI-SIM：用于lrRNAseq评估的受控转录新颖性模拟器
Jorge Mestre-Tomás,Tianyuan Liu,Francisco Pardo-Palacios et al.
Jorge Mestre-Tomás et al.
Long-read RNA sequencing has emerged as a powerful tool for transcript discovery, even in well-annotated organisms. However, assessing the accuracy of different methods in identifying annotated and novel transcripts remains a challenge. Her...
Turnover of strain-level diversity modulates functional traits in the honeybee gut microbiome between nurses and foragers [0.03%]
工蜂和采蜜蜂肠道菌群的菌株水平多样性周转调节其功能特征
Gilles L C Baud,Aiswarya Prasad,Kirsten M Ellegaard et al.
Gilles L C Baud et al.
Background: Strain-level diversity is widespread among bacterial species and can expand the functional potential of natural microbial communities. However, to what extent communities undergo consistent shifts in strain co...
Cotton pedigree genome reveals restriction of cultivar-driven strategy in cotton breeding [0.03%]
棉花亲本基因组揭示了育种策略的局限性
Shang Liu,Dongyun Zuo,Hailiang Cheng et al.
Shang Liu et al.
Background: Many elite genes have been identified from the available cotton genomic data, providing various genetic resources for gene-driven breeding. However, backbone cultivar-driven breeding is the most widely applied...
DNA methylation modulated genetic variant effect on gene transcriptional regulation [0.03%]
DNA甲基化调节遗传变异对基因转录调控的作用
Yong Zeng,Rahi Jain,Magnus Lam et al.
Yong Zeng et al.
Background: Expression quantitative trait locus (eQTL) analysis has emerged as an important tool in elucidating the link between genetic variants and gene expression, thereby bridging the gap between risk SNPs and associa...
Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies [0.03%]
组蛋白H3.3 K27M和G34R突变引起胶质瘤细胞PML核小体异常
Hsiao P J Voon,Linda Hii,Andrew Garvie et al.
Hsiao P J Voon et al.
Background: Point mutations in histone variant H3.3 (H3.3K27M, H3.3G34R) and the H3.3-specific ATRX/DAXX chaperone complex are frequent events in pediatric gliomas. These H3.3 point mutations affect many chromatin modific...
GCLiPP: global crosslinking and protein purification method for constructing high-resolution occupancy maps for RNA binding proteins [0.03%]
GCLiPP：用于构建RNA结合蛋白高分辨率占用图的全局交联和蛋白质纯化方法
Wandi S Zhu,Adam J Litterman,Harshaan S Sekhon et al.
Wandi S Zhu et al.
GCLiPP is a global RNA interactome capture method that detects RNA-binding protein (RBP) occupancy transcriptome-wide. GCLiPP maps RBP-occupied sites at a higher resolution than phase separation-based techniques. GCLiPP sequence tags corres...
Integration of datasets for individual prediction of DNA methylation-based biomarkers [0.03%]
集成数据集以基于DNA甲基化生物标志物的个体预测
Charlotte Merzbacher,Barry Ryan,Thibaut Goldsborough et al.
Charlotte Merzbacher et al.
Background: Epigenetic scores (EpiScores) can provide biomarkers of lifestyle and disease risk. Projecting new datasets onto a reference panel is challenging due to separation of technical and biological variation with ar...
Reconstruction of private genomes through reference-based genotype imputation [0.03%]
基于参考基因型估算的私有基因组重构
Matthew J Mosca,Hyunghoon Cho
Matthew J Mosca
Background: Genotype imputation is an essential step in genetic studies to improve data quality and statistical power. Public imputation servers are widely used by researchers to impute their data using otherwise access-c...
Dengue and Zika RNA-RNA interactomes reveal pro- and anti-viral RNA in human cells [0.03%]
登革热和寨卡病毒RNA-RNA互作组揭示人类细胞内促病毒感染和抗病毒感染的RNA
Kuo-Chieh Liao,Xuping Xie,Anna Karin Beatrice Sundstrom et al.
Kuo-Chieh Liao et al.
Background: Identifying host factors is key to understanding RNA virus pathogenicity. Besides proteins, RNAs can interact with virus genomes to impact replication. ...
Meiosis in an asymmetric dikaryotic genome of Tremella fuciformis Tr01 facilitates new chromosome formation [0.03%]
灵芝形雪耳中非对称双倍体基因组的减数分裂促进了新染色体的形成
Youjin Deng,Lin Guo,Longji Lin et al.
Youjin Deng et al.
Background: The dikaryotic stage dominates most of the life cycle in basidiomycetes, and each cell carries two different haploid nuclei. Accurate phasing of these two nuclear genomes and their interactions have long been ...