Intronic small nucleolar RNAs regulate host gene splicing through base pairing with their adjacent intronic sequences [0.03%]
通过与相邻内含子序列碱基配对，内含子小核仁RNA调控宿主基因的剪接事件
Danny Bergeron,Laurence Faucher-Giguère,Ann-Kathrin Emmerichs et al.
Danny Bergeron et al.
Background: Small nucleolar RNAs (snoRNAs) are abundant noncoding RNAs best known for their involvement in ribosomal RNA maturation. In mammals, most expressed snoRNAs are embedded in introns of longer genes and produced ...
HiCognition: a visual exploration and hypothesis testing tool for 3D genomics [0.03%]
HiCognition：一个用于三维基因组视觉探索和假设检验的工具
Christoph C H Langer,Michael Mitter,Roman R Stocsits et al.
Christoph C H Langer et al.
Genome browsers facilitate integrated analysis of multiple genomics datasets yet visualize only a few regions at a time and lack statistical functions for extracting meaningful information. We present HiCognition, a visual exploration and m...
Protocadherin 20 maintains intestinal barrier function to protect against Crohn's disease by targeting ATF6 [0.03%]
原钙黏着蛋白20通过靶向ATF6维持肠道屏障功能以防御克罗恩病
Shanshan Huang,Zhuo Xie,Jing Han et al.
Shanshan Huang et al.
Background: Intestinal barrier dysfunction plays a central role in the pathological onset of Crohn's disease. We identify the cadherin superfamily member protocadherin 20 (PCDH20) as a crucial factor in Crohn's disease. H...
Characterization of large-scale genomic differences in the first complete human genome [0.03%]
第一例人类完整基因组的第一个大规模基因组差异的特征描述
Xiangyu Yang,Xuankai Wang,Yawen Zou et al.
Xiangyu Yang et al.
Background: The first telomere-to-telomere (T2T) human genome assembly (T2T-CHM13) release is a milestone in human genomics. The T2T-CHM13 genome assembly extends our understanding of telomeres, centromeres, segmental dup...
An Atlas of Variant Effects to understand the genome at nucleotide resolution [0.03%]
一个变异效应图谱，在核苷酸分辨率下理解基因组
Douglas M Fowler,David J Adams,Anna L Gloyn et al.
Douglas M Fowler et al.
Sequencing has revealed hundreds of millions of human genetic variants, and continued efforts will only add to this variant avalanche. Insufficient information exists to interpret the effects of most variants, limiting opportunities for pre...
Pei Ni,Yidi Zhao,Ximeng Zhou et al.
Pei Ni et al.
Prime editing is limited by low efficiency in plants. Here, we develop an upgraded engineered plant prime editor in hexaploid wheat, ePPEplus, by introducing a V223A substitution into reverse transcriptase in the ePPEmax* architecture. ePPE...
RAD21 is the core subunit of the cohesin complex involved in directing genome organization [0.03%]
RAD21是染色体粘连复合体的重要组成蛋白，参与基因组高级结构的维持与调控
Yuao Sun,Xin Xu,Wenxue Zhao et al.
Yuao Sun et al.
Background: The ring-shaped cohesin complex is an important factor for the formation of chromatin loops and topologically associating domains (TADs) by loop extrusion. However, the regulation of association between cohesi...
Ha Vu,Jason Ernst
Ha Vu
A large-scale application of the "stacked modeling" approach for chromatin state discovery previously provides a single "universal" chromatin state annotation of the human genome based jointly on data from many cell and tissue types. Here, ...
Panhematopoietic RNA barcoding enables kinetic measurements of nucleate and anucleate lineages and the activation of myeloid clones following acute platelet depletion [0.03%]
全血细胞RNA条形码能够对造血有核和无核谱系的动态变化以及急性血小板耗竭后髓系克隆活化进行测量
Edyta E Wojtowicz,Jayna J Mistry,Vladimir Uzun et al.
Edyta E Wojtowicz et al.
Background: Platelets and erythrocytes constitute over 95% of all hematopoietic stem cell output. However, the clonal dynamics of HSC contribution to these lineages remains largely unexplored. ...
ExplaiNN: interpretable and transparent neural networks for genomics [0.03%]
ExplaiNN：基因组学的可解释透明神经网络
Gherman Novakovsky,Oriol Fornes,Manu Saraswat et al.
Gherman Novakovsky et al.
Deep learning models such as convolutional neural networks (CNNs) excel in genomic tasks but lack interpretability. We introduce ExplaiNN, which combines the expressiveness of CNNs with the interpretability of linear models. ExplaiNN can pr...