Pervasive under-dominance in gene expression underlying emergent growth trajectories in Arabidopsis thaliana hybrids [0.03%]
拟南芥杂种生长轨迹中普遍存在的转录潜隐现象
Wei Yuan,Fiona Beitel,Thanvi Srikant et al.
Wei Yuan et al.
Background: Complex traits, such as growth and fitness, are typically controlled by a very large number of variants, which can interact in both additive and non-additive fashion. In an attempt to gauge the relative import...
Single-cell transcriptomics reveals multiple chemoresistant properties in leukemic stem and progenitor cells in pediatric AML [0.03%]
单细胞转录组揭示了儿童急性髓系白血病干细胞和祖细胞中的多种化疗耐药属性
Yongping Zhang,Shuting Jiang,Fuhong He et al.
Yongping Zhang et al.
Background: Cancer patients can achieve dramatic responses to chemotherapy yet retain resistant tumor cells, which ultimately results in relapse. Although xenograft model studies have identified several cellular and molec...
A DNA adenine demethylase impairs PRC2-mediated repression of genes marked by a specific chromatin signature [0.03%]
DNA腺嘌呤去甲基化酶通过特定染色质标志物阻碍PRC2介导的基因抑制作用
Qingxiao Jia,Xinran Zhang,Qian Liu et al.
Qingxiao Jia et al.
Background: The Fe (II)- and α-ketoglutarate-dependent AlkB family dioxygenases are implicated in nucleotide demethylation. AlkB homolog1 (ALKBH1) is shown to demethylate DNA adenine methylation (6mA) preferentially from...
Lauren Mak,Dmitry Meleshko,David C Danko et al.
Lauren Mak et al.
Synthetic long read sequencing techniques such as UST's TELL-Seq and Loop Genomics' LoopSeq combine 3[Formula: see text] barcoding with standard short-read sequencing to expand the range of linkage resolution from hundreds to tens of thousa...
A high-resolution genotype-phenotype map identifies the TaSPL17 controlling grain number and size in wheat [0.03%]
高分辨率的基因型-表型图谱鉴定了控制小麦穗粒数和粒重的TaSPL17基因
Yangyang Liu,Jun Chen,Changbin Yin et al.
Yangyang Liu et al.
Background: Large-scale genotype-phenotype association studies of crop germplasm are important for identifying alleles associated with favorable traits. The limited number of single-nucleotide polymorphisms (SNPs) in most...
Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer [0.03%]
跨物种肿瘤基因组学为人类肌层浸润性膀胱癌提供见解
Kim Wong,Federico Abascal,Latasha Ludwig et al.
Kim Wong et al.
Background: In humans, muscle-invasive bladder cancer (MIBC) is highly aggressive and associated with a poor prognosis. With a high mutation load and large number of altered genes, strategies to delineate key driver event...
SCA: recovering single-cell heterogeneity through information-based dimensionality reduction [0.03%]
基于信息的降维单细胞异质性恢复技术(SCA)
Benjamin DeMeo,Bonnie Berger
Benjamin DeMeo
Dimensionality reduction summarizes the complex transcriptomic landscape of single-cell datasets for downstream analyses. Current approaches favor large cellular populations defined by many genes, at the expense of smaller and more subtly d...
Single-cell resolution analysis reveals the preparation for reprogramming the fate of stem cell niche in cotton lateral meristem [0.03%]
单细胞分辨率分析揭示了棉花侧分生组织干细胞龛命运重塑的前期准备
Xiangqian Zhu,Zhongping Xu,Guanying Wang et al.
Xiangqian Zhu et al.
Background: Somatic embryogenesis is a major process for plant regeneration. However, cell communication and the gene regulatory network responsible for cell reprogramming during somatic embryogenesis are still largely un...
Comprehensive analyses of partially methylated domains and differentially methylated regions in esophageal cancer reveal both cell-type- and cancer-specific epigenetic regulation [0.03%]
对食管癌部分甲基化域和差异甲基化区域的综合分析揭示了细胞类型特异性和癌症特异性的表观遗传调控
Yueyuan Zheng,Benjamin Ziman,Allen S Ho et al.
Yueyuan Zheng et al.
Background: As one of the most common malignancies, esophageal cancer has two subtypes, squamous cell carcinoma and adenocarcinoma, arising from distinct cells-of-origin. Distinguishing cell-type-specific molecular featur...
Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal [0.03%]
部分基因抑制可改善CRISPR-Cas9完全丧失功能导致的癌症脆弱性识别问题
J Michael Krill-Burger,Joshua M Dempster,Ashir A Borah et al.
J Michael Krill-Burger et al.
Background: Hundreds of functional genomic screens have been performed across a diverse set of cancer contexts, as part of efforts such as the Cancer Dependency Map, to identify gene dependencies-genes whose loss of funct...