ER tethering and active transport govern condensate diffusion during hyperosmotic stress [0.03%]
渗透压胁迫下凝聚物的扩散受内质网定位和主动运输的调节
Bisal Halder,Guoming Gao,Armin Ahnoud et al.
Bisal Halder et al.
Background: Hyperosmotic shock and the resulting cell volume compression are commonly experienced by organs such as the kidneys, causing rapid formation of hyperosmotic phase separation (HOPS) condensates in the cytoplasm...
Unraveling the complexity of the histone code: implications for gene regulation and disease [0.03%]
解开组蛋白密码的复杂性：对基因调控和疾病的影响
Kiera L Malone,Ajit K Singh,James M Lignos et al.
Kiera L Malone et al.
Histone post-translational modifications epigenetically regulate gene expression by modulating nucleosome structure and DNA accessibility. This review outlines how unique patterns of modifications on canonical and variant histones generate ...
The cellular landscape of i-motifs: genomic insights, methodological challenges, and the road ahead [0.03%]
i- motif的细胞景观：基因组见解、方法论挑战和未来之路
Pallabi Sengupta,Nasim Sabouri
Pallabi Sengupta
Non-canonical DNA structures add a dynamic layer of genome regulation beyond the classical double helix. I-motifs, cytosine-rich four-stranded DNA structures, are increasingly recognized as context-dependent regulators of genome function. R...
Dynamic changes in Lamin B1 and heterochromatin coincide with chromatin condensation during human erythropoiesis [0.03%]
人在红细胞生成过程中染色质浓缩时Lamin B1和异染色质的动态变化同步发生
Rui Wen,Qiqi Zhang,Yiqi Li et al.
Rui Wen et al.
Background: Chromatin condensation, accompanied by pronounced nuclear shrinkage, is a pivotal step in terminal erythroid differentiation and is essential for enucleation. However, the precise timing and molecular mechanis...
Co-occurrence of rare variants implicates gene pairs in cytoskeletal pathways and is associated with increased severity in autism spectrum disorder [0.03%]
罕见变异的共发生暗示自闭症光谱障碍细胞骨架通路中的基因对及其与疾病严重程度增加相关性
Hyeji Lee,Kahee Ko,Seoyeon Kim et al.
Hyeji Lee et al.
Background: The genetic basis of autism spectrum disorder (ASD) is complicated by high heritability and substantial heterogeneity, in which de novo variants and polygenic burden from common variants have not been comprehe...
A kingdom-wide full-length RNA atlas reveals the evolutionary landscapes of plant poly(A) tails [0.03%]
泛王国全长RNA图谱揭示了植物聚腺苷酸尾的进化景观
Yang Chen,Wenqin Lu,Hai He et al.
Yang Chen et al.
Background: Poly(A) tails play crucial roles in regulating mRNA degradation and translation, yet their evolutionary dynamics remain largely unexplored. Re...
Sex chromosome evolution mediated by a large inversion and a possible switch of the sex determination gene [0.03%]
由大的倒位介导的性染色体演化及性别决定基因可能发生的转换事件
Xiaomeng Mao,Nima Rafati,Christian Tellgren-Roth et al.
Xiaomeng Mao et al.
Background: Sex chromosomes often evolve faster than autosomes and commonly degenerate after recombination arrest. However, the underlying evolutionary processes are under persistent debate. In particular, it is unclear w...
Phase separation of β-catenin assembles active loop hubs in colorectal cancer [0.03%]
β-连环蛋白相分离在结直肠癌中形成活性回路中心
Jiyuan Yang,Jun Sun,Hanyi Zhang et al.
Jiyuan Yang et al.
Background: Aberrant three-dimensional genome organization is a hallmark of cancer. However, the underlying regulatory mechanisms remain elusive. Results:...
Dynamic and cell-type specific transcriptional reprogramming underlies the floral transition in the maize shoot apical meristem [0.03%]
玉米 shoots顶芽 汞中开花顶芽形成的动态细胞类型特异性转录重编程
Liang Dong,Yonghao Sun,Lu Kang et al.
Liang Dong et al.
Background: The floral transition in maize represents a pivotal developmental switch that determines flowering time, environmental adaptation, and yield-related traits. However, the molecular mechanisms governing shoot ap...
IFDlong: a model-based isoform and fusion detector for accurate annotation and quantification of long-read RNA-seq data [0.03%]
IFDlong：一种基于模型的同种型和融合检测器，用于长读RNA测序数据的准确注释和定量
Wenjia Wang,Jia-Jun Liu,Yuzhen Li et al.
Wenjia Wang et al.
Long-read transcriptome sequencing (long-RNA-seq) revolutionizes transcriptome research by enabling full-length transcript analysis for comprehensive exploration of isoform diversity. We developed IFDlong, a probabilistic framework and soft...