Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein [0.03%]
分析自闭症相关的16p11.2位点确定神经解剖表型中的多个驱动因素并揭示主要 Vault 蛋白的男性特异性作用
Perrine F Kretz,Christel Wagner,Anna Mikhaleva et al.
Perrine F Kretz et al.
Background: Using mouse genetic studies and systematic assessments of brain neuroanatomical phenotypes, we set out to identify which of the 30 genes causes brain defects at the autism-associated 16p11.2 locus. ...
Fake IDs? Widespread misannotation of DNA transposons as a general transcription factor [0.03%]
假冒身份？DNA转座子被广泛误标为一般转录因子
Nozhat T Hassan,David L Adelson
Nozhat T Hassan
Accurate annotation of genes and transposable elements (TEs) is vital for understanding genomes, but current annotation pipelines often misannotate TEs as genes. This study reveals how the general transcription factor II-I repeat domain-con...
Evaluation of deep learning-based feature selection for single-cell RNA sequencing data analysis [0.03%]
基于深度学习的特征选择在单细胞RNA测序数据分析中的评估
Hao Huang,Chunlei Liu,Manoj M Wagle et al.
Hao Huang et al.
Background: Feature selection is an essential task in single-cell RNA-seq (scRNA-seq) data analysis and can be critical for gene dimension reduction and downstream analyses, such as gene marker identification and cell typ...
Statistical learning quantifies transposable element-mediated cis-regulation [0.03%]
统计学习量化转座元件介导的顺式调控
Cyril Pulver,Delphine Grun,Julien Duc et al.
Cyril Pulver et al.
Background: Transposable elements (TEs) have colonized the genomes of most metazoans, and many TE-embedded sequences function as cis-regulatory elements (CREs) for genes involved in a wide range of biological processes fr...
Zeyang Shen,Lukian Robert,Milan Stolpman et al.
Zeyang Shen et al.
Background: Metagenome-assembled genomes have greatly expanded the reference genomes for skin microbiome. However, the current reference genomes are largely based on samples from adults in North America and lack represent...
Phytochromes transmit photoperiod information via the evening complex in Brachypodium [0.03%]
拟南芥PHYTOCHROMES通过evening复合体传导光周期信息
Mingjun Gao,Yunlong Lu,Feng Geng et al.
Mingjun Gao et al.
Background: Daylength is a key seasonal cue for animals and plants. In cereals, photoperiodic responses are a major adaptive trait, and alleles of clock genes such as PHOTOPERIOD1 (PPD1) and EARLY FLOWERING3 (ELF3) have b...
Author Correction: Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture [0.03%]
更正：由Dog10K联盟进行的2000只犬基因组测序促进了对人口统计，基因组功能和结构的理解
Jennifer R S Meadows,Jefrey M Kidd,Guo-Dong Wang et al.
Jennifer R S Meadows et al.
Published Erratum
Genome biology. 2023 Nov 7;24(1):255. DOI:10.1186/s13059-023-03101-w 2023
Georgi K Marinov,S Tansu Bagdatli,Tong Wu et al.
Georgi K Marinov et al.
Background: Archaea, together with Bacteria, represent the two main divisions of life on Earth, with many of the defining characteristics of the more complex eukaryotes tracing their origin to evolutionary innovations fir...
Lukas Theo Schmitt,Aksana Schneider,Jonas Posorski et al.
Lukas Theo Schmitt et al.
We introduce DEQSeq, a nanopore sequencing approach that rationalizes the selection of favorable genome editing enzymes from directed molecular evolution experiments. With the ability to capture full-length sequences, editing efficiencies, ...
In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation [0.03%]
类器官单细胞CRISPR筛选揭示肝细胞分化和成熟的决定因素
Junbo Liang,Jinsong Wei,Jun Cao et al.
Junbo Liang et al.
Background: Harnessing hepatocytes for basic research and regenerative medicine demands a complete understanding of the genetic determinants underlying hepatocyte differentiation and maturation. Single-cell CRISPR screens...