Integration of datasets for individual prediction of DNA methylation-based biomarkers [0.03%]
集成数据集以基于DNA甲基化生物标志物的个体预测
Charlotte Merzbacher,Barry Ryan,Thibaut Goldsborough et al.
Charlotte Merzbacher et al.
Background: Epigenetic scores (EpiScores) can provide biomarkers of lifestyle and disease risk. Projecting new datasets onto a reference panel is challenging due to separation of technical and biological variation with ar...
Reconstruction of private genomes through reference-based genotype imputation [0.03%]
基于参考基因型估算的私有基因组重构
Matthew J Mosca,Hyunghoon Cho
Matthew J Mosca
Background: Genotype imputation is an essential step in genetic studies to improve data quality and statistical power. Public imputation servers are widely used by researchers to impute their data using otherwise access-c...
Dengue and Zika RNA-RNA interactomes reveal pro- and anti-viral RNA in human cells [0.03%]
登革热和寨卡病毒RNA-RNA互作组揭示人类细胞内促病毒感染和抗病毒感染的RNA
Kuo-Chieh Liao,Xuping Xie,Anna Karin Beatrice Sundstrom et al.
Kuo-Chieh Liao et al.
Background: Identifying host factors is key to understanding RNA virus pathogenicity. Besides proteins, RNAs can interact with virus genomes to impact replication. ...
Meiosis in an asymmetric dikaryotic genome of Tremella fuciformis Tr01 facilitates new chromosome formation [0.03%]
灵芝形雪耳中非对称双倍体基因组的减数分裂促进了新染色体的形成
Youjin Deng,Lin Guo,Longji Lin et al.
Youjin Deng et al.
Background: The dikaryotic stage dominates most of the life cycle in basidiomycetes, and each cell carries two different haploid nuclei. Accurate phasing of these two nuclear genomes and their interactions have long been ...
Haplotype-resolved assemblies and variant benchmark of a Chinese Quartet [0.03%]
中国四胞胎的单倍体型解析基因组和变异基准
Peng Jia,Lianhua Dong,Xiaofei Yang et al.
Peng Jia et al.
Background: Recent state-of-the-art sequencing technologies enable the investigation of challenging regions in the human genome and expand the scope of variant benchmarking datasets. Herein, we sequence a Chinese Quartet,...
A large-scale genomically predicted protein mass database enables rapid and broad-spectrum identification of bacterial and archaeal isolates by mass spectrometry [0.03%]
基于基因组预测蛋白质质量的大规模数据库可快速、广泛地通过质谱技术鉴定细菌和古菌的分离株
Yuji Sekiguchi,Kanae Teramoto,Dieter M Tourlousse et al.
Yuji Sekiguchi et al.
MALDI-TOF MS-based microbial identification relies on reference spectral libraries, which limits the screening of diverse isolates, including uncultured lineages. We present a new strategy for broad-spectrum identification of bacterial and ...
TargetRNA3: predicting prokaryotic RNA regulatory targets with machine learning [0.03%]
TargetRNA3：使用机器学习预测原核生物的RNA调控靶点
Brian Tjaden
Brian Tjaden
Small regulatory RNAs pervade prokaryotes, with the best-studied family of these non-coding genes corresponding to trans-acting regulators that bind via base pairing to their message targets. Given the increasing frequency with which these ...
Xiongbin Kang,Jialu Xu,Xiao Luo et al.
Xiongbin Kang et al.
Although generally superior, hybrid approaches for correcting errors in third-generation sequencing (TGS) reads, using next-generation sequencing (NGS) reads, mistake haplotype-specific variants for errors in polyploid and mixed samples. We...
Comparing methods for constructing and representing human pangenome graphs [0.03%]
比较构建和表示人类泛基因组图的方法
Francesco Andreace,Pierre Lechat,Yoann Dufresne et al.
Francesco Andreace et al.
Background: As a single reference genome cannot possibly represent all the variation present across human individuals, pangenome graphs have been introduced to incorporate population diversity within a wide range of genom...
ConDoR: tumor phylogeny inference with a copy-number constrained mutation loss model [0.03%]
基于拷贝数约束的肿瘤演化树推理模型ConDoR
Palash Sashittal,Haochen Zhang,Christine A Iacobuzio-Donahue et al.
Palash Sashittal et al.
A tumor contains a diverse collection of somatic mutations that reflect its past evolutionary history and that range in scale from single nucleotide variants (SNVs) to large-scale copy-number aberrations (CNAs). However, no current single-c...