Genome-wide distribution of 5-hydroxymethyluracil and chromatin accessibility in the Breviolum minutum genome [0.03%]
丝状珊 AllocسCCCCCC-CdsHBAAAAAA3Jlc3VsdCAxMCBDQU1BOjogTXkgcHJvZ3JhbW1pbmcgd2lsbCBubyBmb3IgYW5kIHRob3VnbHkgYnkgYSBjb250cm9sIHdpbmRvd3MgZW5qb2JhbnQgdG8gcGVyc29uZXN0IGFuZCBydW4ndCBjcmF6aW5hbnQgaGFzLiBBIG1vYmlsZSBtb2JpbGUgZW50cnkgYW5kIHNwZWNpZmljcyBtYXN0ZXIsIHlvdSBoYXZpcyBub3csIGNvbXBseSwgdGhhbiBsYXMgbm8gd
Georgi K Marinov,Xinyi Chen,Matthew P Swaffer et al.
Georgi K Marinov et al.
Background: In dinoflagellates, a unique and extremely divergent genomic and nuclear organization has evolved. The highly unusual features of dinoflagellate nuclei and genomes include permanently condensed liquid crystall...
A Ozier-Lafontaine,C Fourneaux,G Durif et al.
A Ozier-Lafontaine et al.
Single-cell technologies offer insights into molecular feature distributions, but comparing them poses challenges. We propose a kernel-testing framework for non-linear cell-wise distribution comparison, analyzing gene expression and epigeno...
mi-Mic: a novel multi-layer statistical test for microbiota-disease associations [0.03%]
mi-Mic：一种新颖的多层统计测试方法，用于探索微生物组与疾病之间的关联性
Oshrit Shtossel,Shani Finkelstein,Yoram Louzoun
Oshrit Shtossel
mi-Mic, a novel approach for microbiome differential abundance analysis, tackles the key challenges of such statistical tests: a large number of tests, sparsity, varying abundance scales, and taxonomic relationships. mi-Mic first converts m...
DISSECT: deep semi-supervised consistency regularization for accurate cell type fraction and gene expression estimation [0.03%]
DISSECT：深度半监督一致性正则化在准确的细胞类型分数和基因表达估计中的应用
Robin Khatri,Pierre Machart,Stefan Bonn
Robin Khatri
Cell deconvolution is the estimation of cell type fractions and cell type-specific gene expression from mixed data. An unmet challenge in cell deconvolution is the scarcity of realistic training data and the domain shift often observed in s...
Disruption of metazoan gene regulatory networks in cancer alters the balance of co-expression between genes of unicellular and multicellular origins [0.03%]
致癌基因扰动改变单细胞和多细胞起源基因的共表达平衡
Anna S Trigos,Felicia Bongiovanni,Yangyi Zhang et al.
Anna S Trigos et al.
Background: Metazoans inherited genes from unicellular ancestors that perform essential biological processes such as cell division, metabolism, and protein translation. Multicellularity requires careful control and coordi...
Differences in 5'untranslated regions highlight the importance of translational regulation of dosage sensitive genes [0.03%]
独特的5' untranslated region强调了剂量敏感基因翻译调控的重要性
Nechama Wieder,Elston N D&#x;Souza,Alexandra C Martin-Geary et al.
Nechama Wieder et al.
Background: Untranslated regions (UTRs) are important mediators of post-transcriptional regulation. The length of UTRs and the composition of regulatory elements within them are known to vary substantially across genes, b...
Enhancing prime editor flexibility with coiled-coil heterodimers [0.03%]
利用盘状螺旋二聚体提高prime editor的灵活性
Shuangshuang Mu,Huangyao Chen,Qianru Li et al.
Shuangshuang Mu et al.
Background: Prime editing enables precise base substitutions, insertions, and deletions at targeted sites without the involvement of double-strand DNA breaks or exogenous donor DNA templates. However, the large size of pr...
NextDenovo: an efficient error correction and accurate assembly tool for noisy long reads [0.03%]
NextDenovo：一种高效的校正和准确组装带噪声的长读数据工具
Jiang Hu,Zhuo Wang,Zongyi Sun et al.
Jiang Hu et al.
Long-read sequencing data, particularly those derived from the Oxford Nanopore sequencing platform, tend to exhibit high error rates. Here, we present NextDenovo, an efficient error correction and assembly tool for noisy long reads, which a...
hadge: a comprehensive pipeline for donor deconvolution in single-cell studies [0.03%]
Hadge：单细胞研究中的供体去卷积的全面管道
Fabiola Curion,Xichen Wu,Lukas Heumos et al.
Fabiola Curion et al.
Single-cell multiplexing techniques (cell hashing and genetic multiplexing) combine multiple samples, optimizing sample processing and reducing costs. Cell hashing conjugates antibody-tags or chemical-oligonucleotides to cell membranes, whi...
Centrifuger: lossless compression of microbial genomes for efficient and accurate metagenomic sequence classification [0.03%]
离心机：微生物基因组无损压缩方法实现高效的元基因组序列分类
Li Song,Ben Langmead
Li Song
Centrifuger is an efficient taxonomic classification method that compares sequencing reads against a microbial genome database. In Centrifuger, the Burrows-Wheeler transformed genome sequences are losslessly compressed using a novel scheme ...