Response to Commentary: Accounting for diverse transposable element landscapes is key to developing and evaluating accurate de novo annotation strategies [0.03%]
对评论的回应：会计多样化可移动元素景观对于开发和评估准确的从头注释策略至关重要
Shujun Ou,Ning Jiang,Candice N Hirsch et al.
Shujun Ou et al.
Genetic effects of sequence-conserved enhancer-like elements on human complex traits [0.03%]
类似增强子的序列保守元件对人类复杂性状的遗传影响
Xiang Zhu,Shining Ma,Wing Hung Wong
Xiang Zhu
Background: The vast majority of findings from human genome-wide association studies (GWAS) map to non-coding sequences, complicating their mechanistic interpretations and clinical translations. Non-coding sequences that ...
FORGEdb: a tool for identifying candidate functional variants and uncovering target genes and mechanisms for complex diseases [0.03%]
FORGEdb：一种用于识别复杂疾病的功能变异、靶基因及机制的工具
Charles E Breeze,Eric Haugen,María Gutierrez-Arcelus et al.
Charles E Breeze et al.
The majority of disease-associated variants identified through genome-wide association studies are located outside of protein-coding regions. Prioritizing candidate regulatory variants and gene targets to identify potential biological mecha...
Author Correction: Homology-mediated inter-chromosomal interactions in hexaploid wheat lead to specific subgenome territories following polyploidization and introgression [0.03%]
作者更正：六倍体小麦中通过同源介导的染色体间相互作用，在多倍化和渗入后形成特定亚基因组区域
Jizeng Jia,Yilin Xie,Jingfei Cheng et al.
Jizeng Jia et al.
Published Erratum
Genome biology. 2024 Jan 2;25(1):5. DOI:10.1186/s13059-023-03154-x 2024
Tissue-specific RNA Polymerase II promoter-proximal pause release and burst kinetics in a Drosophila embryonic patterning network [0.03%]
果蝇胚胎构型网络中组织特异性RNA聚合酶II启动子近端暂停释放和爆发动力学
George Hunt,Roshan Vaid,Sergei Pirogov et al.
George Hunt et al.
Background: Formation of tissue-specific transcriptional programs underlies multicellular development, including dorsoventral (DV) patterning of the Drosophila embryo. This involves interactions between transcriptional en...
Accounting for diverse transposable element landscapes is key to developing and evaluating accurate de novo annotation strategies [0.03%]
考虑到不同的转座元件景观是开发和评估准确的从头注释策略的关键
Landen Gozashti,Hopi E Hoekstra
Landen Gozashti
Transposable elements (TEs) are important drivers of genome evolution. Nonetheless, TE annotation remains a complex and challenging task. As more genomes from phylogenetically diverse species are published, a comprehensive pipeline for accu...
ENGEP: advancing spatial transcriptomics with accurate unmeasured gene expression prediction [0.03%]
ENGEP：通过精确的未测量基因表达预测推进空间转录组学的发展
Shi-Tong Yang,Xiao-Fei Zhang
Shi-Tong Yang
Imaging-based spatial transcriptomics techniques provide valuable spatial and gene expression information at single-cell resolution. However, their current capability is restricted to profiling a limited number of genes per sample, resultin...
Benchmarking splice variant prediction algorithms using massively parallel splicing assays [0.03%]
使用大规模并行剪接测定法对剪接变异预测算法进行评估
Cathy Smith,Jacob O Kitzman
Cathy Smith
Background: Variants that disrupt mRNA splicing account for a sizable fraction of the pathogenic burden in many genetic disorders, but identifying splice-disruptive variants (SDVs) beyond the essential splice site dinucle...
Noé Cochetel,Andrea Minio,Andrea Guarracino et al.
Noé Cochetel et al.
Background: Capturing the genetic diversity of wild relatives is crucial for improving crops because wild species are valuable sources of agronomic traits that are essential to enhance the sustainability and adaptability ...
scNAT: a deep learning method for integrating paired single-cell RNA and T cell receptor sequencing profiles [0.03%]
scNAT：一种深度学习方法，用于整合配对的单细胞RNA和T细胞受体测序谱型
Biqing Zhu,Yuge Wang,Li-Ting Ku et al.
Biqing Zhu et al.
Many deep learning-based methods have been proposed to handle complex single-cell data. Deep learning approaches may also prove useful to jointly analyze single-cell RNA sequencing (scRNA-seq) and single-cell T cell receptor sequencing (scT...