Reproductive mode and ploidy are associated with distinct organization of clustered centromeric regions in Meloidogyne nematodes [0.03%]
根结线虫中生殖方式和染色体倍性与簇集型着丝粒区域的组织相关性研究
Evelin Despot-Slade,Marin Volarić,Damira Veseljak et al.
Evelin Despot-Slade et al.
Background: In most eukaryotes, chromosomes are monocentric, each containing a single centromeric region. However, plant-parasitic nematodes of the genus Meloidogyne display a unique, repeat-based and clustered centromere...
Fine-tuning sequence-to-expression models on personal genome and transcriptome data [0.03%]
在个人基因组和转录组数据上微调序列到表达模型
Ruchir Rastogi,Aniketh Janardhan Reddy,Ryan Chung et al.
Ruchir Rastogi et al.
Background: Genomic sequence-to-expression deep learning models, which are trained to predict gene expression and other molecular phenotypes across the reference genome, have recently been shown to have poor out-of-the-bo...
FLNB and TTC26 regulate ciliary Hedgehog signaling to maintain intervertebral disc matrix homeostasis in adolescent idiopathic scoliosis [0.03%]
FLNB和TTC26通过调控青少年特发性脊柱侧弯中椎间盘基质稳态的纤毛型 Hedgehog信号通路发挥作用
Heng Jiang,Yuan Gao,Bowen Lai et al.
Heng Jiang et al.
Background: Adolescent idiopathic scoliosis (AIS) is a complex spinal deformity with evidence of contributions from multiple genetic factors, but the molecular basis of gene-gene interactions in its development remains un...
Bacterial 3D genome architecture: organization, regulation, and synthetic biology applications [0.03%]
细菌三维基因组构象：组织、调控及合成生物学应用
Mao Chen,Ziyi Zhu,Yuhuan Huang et al.
Mao Chen et al.
Bacterial chromosomes are compacted into hierarchical three-dimensional (3D) architectures that underpin essential processes such as replication, transcription, and segregation. However, detailed principles governing genome architecture and...
ReSkmer: modeling repeats allows k-mer-based alignment-free methods to calculate population genomic distances [0.03%]
循环重复模式对基于k-мер的无参比基因组距离计算的影响研究
Eduardo Charvel,Isaac Thomas,Homère J Alves Monteiro et al.
Eduardo Charvel et al.
Understanding ecological change requires robust, inexpensive methods for monitoring populations. One approach is using low-coverage genome sequencing (genome skimming) to compute genetic diversity via assembly-free, alignment-free, k-mer-ba...
A reference genome for cultured Drosophila ovarian somatic cells enables studies of transposon and piRNA biology [0.03%]
果蝇卵巢体细胞系参考基因组的测定使转座子和piRNA生物学研究成为可能
Dominik Handler,Julius Brennecke
Dominik Handler
Background: Accurate reconstruction of repetitive genomic regions is essential to understand small RNA-mediated transposon silencing. In Drosophila ovarian somatic cells (OSCs), a primary model for nuclear PIWI-piRNA biol...
Spatial transcriptomics reveals influence of microenvironment on intrinsic fates in melanoma therapy resistance [0.03%]
空间转录组学揭示了微环境对黑色素瘤治疗抵抗的内在命运的影响
Ryan H Boe,Catherine G Triandafillou,Rossana Lazcano et al.
Ryan H Boe et al.
Resistance to cancer therapy is driven by both cell-intrinsic and microenvironmental factors. We use spatial transcriptomics and single-cell RNA sequencing to uncover distinct resistance programs in melanoma cells shaped by intrinsic cellul...
Pro-regenerative fingerprints identified in a sub-population of adult mouse cardiomyocytes by integrative single-cell proteomics [0.03%]
整合单细胞蛋白质组学在小鼠成体心肌细胞亚群中鉴定出促再生的特征性蛋白指纹图谱
Consuelo Marín-Vicente,Cristina Villa Del Campo,Enrique Calvo et al.
Consuelo Marín-Vicente et al.
Background: Recent advances in instrument sensitivity and sample preparation techniques are significantly improving the ability to study the heterogeneity of cell populations at the single-cell level by mass spectrometry-...
Histone H1 variants regulate neurodevelopmental transcriptional programs in autism with 16p11.2 deletion [0.03%]
16p11.2缺失自闭症中组蛋白H1变体调控神经发育转录程序
Roni Brudno,Dan Askayo,Doha Khair et al.
Roni Brudno et al.
Background: Neurodevelopmental disorders, including autism spectrum disorder, involve widespread transcriptional dysregulation. Copy number variations at 16p11.2 are among the strongest genetic risk factors for autism spe...
Advancing generative large language models toward discriminative performance in protein function prediction [0.03%]
生成式大型语言模型在蛋白质功能预测方面向判别式性能的进展
Ying Lv,Yifan Xu,Gang Xu et al.
Ying Lv et al.
Background: While generative large language models (LLMs) have revolutionized diverse research domains through their advanced semantic understanding capabilities, their applications to protein function prediction remain l...