A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium [0.03%]
一个H3K27me3阅读复合体在草履虫中将H3K27me3累积与转座元件的新生转录偶联在一起
Thomas Balan,Ambre Petitalot,Julien Richard Albert et al.
Thomas Balan et al.
Background: The ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repressive complex 1 (PRC1...
MRBEE-TL: improving causal effect estimation in multi-ancestry multivariable Mendelian randomization with transfer learning [0.03%]
基于迁移学习的多祖先多变量孟德尔随机化因果效应估计方法研究
Yihe Yang,Xiaofeng Zhu
Yihe Yang
Multivariable Mendelian randomization has been largely applied to individuals of European ancestry, due to the larger sample sizes available in European GWAS. We introduce MRBEE-TL, one of the first multi-ancestry multivariable Mendelian ra...
Predicting extinction risk of gibbons from genomes of extinct Yunnan lar gibbon [0.03%]
基于已灭绝白眉叶猴基因组预测长臂猿濒危风险
Ayun Luo,Hang-Yu Tian,Song Li et al.
Ayun Luo et al.
Background: All species of gibbons are endangered, with the Yunnan lar gibbons (Hylobates lar yunnanensis) officially declared extinct in the wild in 2022. While human activities are frequently cited as major factor, the ...
Benchmarking single-cell tumor immune atlases and application for uncovering cell states related to immunotherapy response [0.03%]
单细胞肿瘤免疫图谱的基准测试及在发现与免疫治疗反应相关的细胞状态方面的应用
Jing Yang,Yu Shyr,Qi Liu
Jing Yang
Background: The tumor immune microenvironment, containing a variety of immune cells with both tumor-promoting and anti-tumoral functions, plays a significant role in tumor immune surveillance and immunological evasion. Ch...
EMF2b-1 regulates endosperm cell cycling through PRC2 recruitment in maize [0.03%]
ZmEMF2b-1通过募集PRC2调控玉米胚乳细胞周期
Jiameng Xu,Ying Zhang,Ke Qing et al.
Jiameng Xu et al.
Background: Polycomb Repressive Complex 2 (PRC2) establishes H3K27me3 to regulate gene expression, yet how its genomic targeting is achieved in large crop genomes remains unclear. Cereal endosperm development relies on ti...
Functional characterization of transporter genes in rice node at single-cell resolution through multi-omics technologies [0.03%]
利用多组学技术在单细胞分辨率下解析水稻营养腔转运蛋白基因功能
Hu Li,Huiling Jin,Min Ning et al.
Hu Li et al.
Background: The rice node is a critical hub for the distribution of mineral nutrients, mediated by transporters. Manganese (Mn) is an essential micronutrient for plant growth. However, the precise cell types and the cell-...
DeepISO: deep learning-powered prediction of protein-protein interaction rewiring generated by alternative splicing [0.03%]
深度学习驱动的可变剪接诱导的蛋白质互作动态预测
Xiaokun Guo,Linyang Jiang,Jiajun Li et al.
Xiaokun Guo et al.
Isoforms from the same gene can significantly rewire protein interaction networks, but proteome-wide computational evaluation of these effects remains challenging. In this work, we present DeepISO, a deep learning framework for predicting i...
ImmuSeeker: deep mining of immune-related gene family signatures through lineage reconstruction [0.03%]
基于谱系重建的免疫相关基因家族标志深度挖掘方法：ImmuSeeker
Limin Jiang,Ivy Hurwitz,Lukasz S Wylezinski et al.
Limin Jiang et al.
HLA typing from sequencing data is crucial for studying immune gene families, but high allele similarity challenges existing tools. We present ImmuSeeker, comprehensive software for extracting HLA genotypes, expression, and diversity at gen...
Alu-mediated RNA duplexes are associated with widespread exon skipping across primate transcriptomes [0.03%]
灵长类转录组中广泛的外显子跳读与由Alu介导的RNA二聚体相关
Hyunbeen Lee,Xinang Cao,Guillermo E Parada et al.
Hyunbeen Lee et al.
Alternative splicing patterns have diverged rapidly during vertebrate evolution. By integrating genome-wide predictions of stable RNA duplexes, alternative splicing profiles, and proximity ligation-detection of RNA-RNA interactions, we obse...
scComm: a contrastive learning framework for deciphering cell-cell communications at single-cell resolution [0.03%]
基于单细胞分辨率的破译细胞间通信的对比学习框架-scComm
Zijie Jin,Zongli Tang,Xinyi Li et al.
Zijie Jin et al.
Cell-cell communication regulates complex biological processes in multicellular systems. Existing scRNA-seq-based methods typically aggregate gene expression by clusters, overlooking within-cluster heterogeneity. We present scComm, a comput...