Incorporating additive genetic effects and linkage disequilibrium information to discover gene-environment interactions using BV-LDER-GE [0.03%]
利用BV-LDER-GE模型发现基因-环境互作效应并整合加性遗传效应和连锁不平衡信息
Zihan Dong,Wei Jiang,Jiangnan Shen et al.
Zihan Dong et al.
Uncovering environmental factors interacting with genetic factors to influence complex traits is important in genetic epidemiology and disease etiology. We introduce BiVariate Linkage-Disequilibrium Eigenvalue Regression for Gene-Environmen...
Unico: a unified model for cell-type resolution genomics from heterogeneous omics data [0.03%]
基于组学数据的单细胞分辨率基因组学统一模型_UNICO
Zeyuan Johnson Chen,Elior Rahmani,Eran Halperin
Zeyuan Johnson Chen
Most population-scale genomic datasets collected to date consist of "bulk" samples obtained from heterogeneous tissues, reflecting mixtures of different cell types. We introduce Unico, a Unified cross-omics computational method designed to ...
GWAS-informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density [0.03%]
基于GWAS的数据库整合及非编码CRISPRi筛选揭示骨密度遗传病因
Mitchell Conery,James A Pippin,Yadav Wagley et al.
Mitchell Conery et al.
Background: Over 1100 independent signals have been identified with genome-wide association studies (GWAS) for bone mineral density (BMD), a key risk factor for mortality-increasing fragility fractures; however, the effec...
Phase-separating fusion proteins drive cancer by upsetting transcription regulation [0.03%]
相分离融合蛋白通过扰乱转录调控驱动癌症发生
Nazanin Farahi,Tamas Lazar,Peter Tompa et al.
Nazanin Farahi et al.
Background: Numerous cellular processes rely on biomolecular condensates formed through liquid-liquid phase separation (LLPS). Recently, it has become evident that somatic mutations can interfere with or over-activate the...
Phase-separating fusion proteins drive cancer by upsetting transcription regulation [0.03%]
相分离融合蛋白通过扰乱转录调控驱动癌症发病
Nazanin Farahi,Tamas Lazar,Peter Tompa et al.
Nazanin Farahi et al.
Background: Numerous cellular processes rely on biomolecular condensates formed through liquid-liquid phase separation (LLPS). Recently, it has become evident that somatic mutations can interfere with or over-activate the...
WUSCHEL-dependent chromatin regulation in maize inflorescence development at single-cell resolution [0.03%]
单细胞分辨率的玉米穗发育过程中WUSCHEL依赖的染色质调控
Sohyun Bang,Xuan Zhang,Jason Gregory et al.
Sohyun Bang et al.
Background: WUSCHEL (WUS) is a homeodomain transcription factor vital for stem cell proliferation in plant meristems. In maize, ZmWUS1 is expressed in the inflorescence meristem, including the central zone reservoir of st...
WUSCHEL-dependent chromatin regulation in maize inflorescence development at single-cell resolution [0.03%]
单细胞分辨率下拟南芥花序发育过程中WUSCHEL依赖的染色质调控
Sohyun Bang,Xuan Zhang,Jason Gregory et al.
Sohyun Bang et al.
Background: WUSCHEL (WUS) is a homeodomain transcription factor vital for stem cell proliferation in plant meristems. In maize, ZmWUS1 is expressed in the inflorescence meristem, including the central zone reservoir of st...
BLEND: probabilistic cellular deconvolution with individualized single-cell reference integration [0.03%]
BLEND：具有个性化单细胞参考整合的概率细胞去卷积
Penghui Huang,Manqi Cai,Chris McKennan et al.
Penghui Huang et al.
Cellular deconvolution estimates cell-type fractions from bulk transcriptomic data, but current methods often overlook cell type-specific expression varying across samples, discrepancies between bulk and single-cell data, or lack guidance o...
BLEND: probabilistic cellular deconvolution with individualized single-cell reference integration [0.03%]
BLEND：具有个性化单细胞参考集成的概率细胞去卷积
Penghui Huang,Manqi Cai,Chris McKennan et al.
Penghui Huang et al.
Cellular deconvolution estimates cell-type fractions from bulk transcriptomic data, but current methods often overlook cell type-specific expression varying across samples, discrepancies between bulk and single-cell data, or lack guidance o...
Phylogenomics provides comprehensive insights into the evolutionary relationships among cultivated buckwheat species [0.03%]
基于基因组的系统发生学研究揭示了栽培荞麦属作物之间的进化关系
Yaliang Shi,Bo Li,Yuanfen Gao et al.
Yaliang Shi et al.
Background: Buckwheat belongs to the family Polygonaceae and genus Fagopyrum, which is characterized by high flavonoid content, short growth period, and strong environmental adaptability. Buckwheat has three cultivated sp...