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期刊名:Genome biology

缩写:GENOME BIOL

ISSN:1474-760X

e-ISSN:1474-760X

IF/分区:9.4/Q1

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共收录本刊相关文章索引6564
Clinical Trial Case Reports Meta-Analysis RCT Review Systematic Review
Classical Article Case Reports Clinical Study Clinical Trial Clinical Trial Protocol Comment Comparative Study Editorial Guideline Letter Meta-Analysis Multicenter Study Observational Study Randomized Controlled Trial Review Systematic Review
Weijian Wang,Yihui Cen,Zezhen Lu et al. Weijian Wang et al.
In droplet-based single-cell and single-nucleus RNA-seq assays, systematic contamination of ambient RNA molecules biases the quantification of gene expression levels. Existing methods correct the contamination for all genes globally. Howeve...
Yanjiao Shao,Canzhao Liu,Hsin-Kai Liao et al. Yanjiao Shao et al.
Background: Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure. Multiple identified mutations in nexilin (NEXN) have been suggested to be linked with severe DCM. However, the exact association ...
Kim L McIntyre,Shafagh A Waters,Ling Zhong et al. Kim L McIntyre et al.
The marsupial specific RSX lncRNA is the functional analogue of the eutherian specific XIST, which coordinates X chromosome inactivation. We characterized the RSX interactome in a marsupial representative (the opossum Monodelphis domestica)...
Patricia Rojas,Jianming Wang,Giovanni Guglielmi et al. Patricia Rojas et al.
Background: DNA replication progression can be affected by the presence of physical barriers like the RNA polymerases, leading to replication stress and DNA damage. Nonetheless, we do not know how transcription influences...
Intekhab Hossain,Viola Fanfani,Jonas Fischer et al. Intekhab Hossain et al.
Background: Gene regulatory network (GRN) models that are formulated as ordinary differential equations (ODEs) can accurately explain temporal gene expression patterns and promise to yield new insights into important cell...
Xiaoshuang Liu,Dongfang Gu,Yiru Zhang et al. Xiaoshuang Liu et al.
Background: High-efficiency prime editing (PE) is desirable for precise genome manipulation. The activity of mammalian PE systems can be largely improved by inhibiting DNA mismatch repair by coexpressing a dominant-negati...
Matthew A Myers,Brian J Arnold,Vineet Bansal et al. Matthew A Myers et al.
Bulk DNA sequencing of multiple samples from the same tumor is becoming common, yet most methods to infer copy-number aberrations (CNAs) from this data analyze individual samples independently. We introduce HATCHet2, an algorithm to identif...
Hima Priyanka Nadimpalli,Georgia Katsioudi,Enes Salih Arpa et al. Hima Priyanka Nadimpalli et al.
Background: Cellular iron homeostasis is regulated by iron regulatory proteins (IRP1 and IRP2) that sense iron levels (and other metabolic cues) and modulate mRNA translation or stability via interaction with iron regulat...