Benchmarking reveals the superiority of nucleic acid foundation models in predicting lncRNA coding potential [0.03%]
基准测试揭示了核酸基础模型在预测长链非编码RNA编码潜力方面的优势
Yu Yang,Liping Ren,Juan Feng et al.
Yu Yang et al.
Background: A subset of long noncoding RNAs (lncRNAs) contains short open reading frames and can encode functional micropeptides. However, identifying these coding lncRNAs (codlncRNAs) remains challenging due to weak codi...
Evidence for G6PD variant classification from multiplexed functional assays [0.03%]
基于多重功能测定的G6PD变异分类证据
Renee C Geck,Melinda K Wheelock,Rachel L Powell et al.
Renee C Geck et al.
Background: G6PD deficiency is one of the most common enzyme deficiencies worldwide, and increases the likelihood of adverse reactions to certain drugs and foods. As availability of routine sequencing and biobanking incre...
Dbp7 interacts with RNA exosome component Dis3 to mediate CENP-A loading to centromeres [0.03%]
Dbp7通过与RNA外切酶组分Dis3的相互作用介导CENP-A在着丝粒上的加载
Jinxin Gao,Fengying Gao,Qianhua Dong et al.
Jinxin Gao et al.
Background: Centromeres are crucial for proper chromosome segregation during cell division. Centromeres in most eukaryotes are epigenetically defined by the histone H3 variant, CENP-A. Centromeric regions are typically tr...
pAnno: a comprehensive, precise, and fast proteogenomic workflow for the discovery of novel coding regions [0.03%]
pAnno：一种全面、精确且快速的蛋白质组学工作流程，用于发现新的编码区
Kaifei Wang,Zhuohong Wei,Changrong Li et al.
Kaifei Wang et al.
Proteogenomics is a transformative approach for deciphering novel coding regions through integration of genomic, transcriptomic, and proteomic data. Here, we present pAnno, an end-to-end workflow designed to uncover hidden protein-coding el...
Publisher Correction: Single-cell epigenetic and transcriptomic states across the continuum of monoclonal B cell lymphocytosis to chronic lymphocytic leukemia [0.03%]
出版更正：从单克隆B细胞淋巴细胞增多症到慢性淋巴细胞性白血病的单细胞表观遗传和转录组状态连续性研究
Anja C Rathgeber,Stacey M Fernandes,Adi Nagler et al.
Anja C Rathgeber et al.
Published Erratum
Genome biology. 2026 Jun 2;27(1):181. DOI:10.1186/s13059-026-04135-6 2026
Hybrid untargeted short-read and targeted long-read RNA sequencing facilitates genotype-phenotype associations at single-cell resolution [0.03%]
基于短读和靶向长读RNA测序的杂交无靶标单细胞基因型与表型关联分析
Jiayi Wang,Maria Constanza Maldifassi,Anna Bratus-Neuenschwander et al.
Jiayi Wang et al.
Long-read single-cell RNA sequencing enables simultaneous and unbiased detection of transcriptomic variants and gene expression, but its application is limited by low read coverage, restricting genotype-phenotype analyses at single-cell res...
FIRST-seq: a nanopore-based cDNA sequencing platform for RNA modification and structure profiling [0.03%]
基于纳米孔的cDNA测序平台用于RNA修饰和结构分析
Oguzhan Begik,Gregor Diensthuber,Ivana Borovska et al.
Oguzhan Begik et al.
RNA modifications induce reverse transcription (RT) errors in an enzyme- and context-dependent manner, enabling transcriptome-wide mapping and RNA structure probing. We present FIRST-seq, a flexible, cost-effective nanopore cDNA method that...
Yan Zhang,Yanhua Xu,Wanyu Shi et al.
Yan Zhang et al.
Hematopoietic stem cells (HSCs) transition through different functional states throughout life from emergence and expansion in the fetus, homeostasis maintenance in adulthood, and progressive functional decline with age. Aged HSCs are chara...
Multi-omics pleiotropic association analyses reveal functionally relevant genes and druggable pathways for ovarian aging [0.03%]
多组学多效性关联分析揭示了与卵巢衰老相关的功能基因和可药用通路
Xuan Lian,Shuang Song,Chen Lou et al.
Xuan Lian et al.
Background: Ovarian aging, marked by the gradual decline in both the number and quality of oocytes, significantly impacts women's reproductive lifespan and overall health. However, the biological mechanisms driving ovaria...
Real-time search-assisted multiplexed quantitative proteomics reveals system-wide cryptic translation initiation in human cancer cells [0.03%]
实时搜索辅助的多重定量蛋白质组学揭示了人类癌细胞中的系统范围内的隐蔽翻译起始
Hiroko Kozuka-Hata,Tomoko Hiroki,Aya Kitamura et al.
Hiroko Kozuka-Hata et al.
Background: It is generally considered that eukaryotic translation initiation prominently occurs from the first AUG codon by ribosomal scanning from the 5-cap end of each mRNA. In order to identify cryptic internal transl...