Benchmarking tools for deciphering cellular crosstalk in spatially-resolved transcriptomics [0.03%]
基准工具解析空间转录组学中细胞间信号通路
Li-Ting Ku,Vincent Bernard,Jimin Min et al.
Li-Ting Ku et al.
Background: Cell-cell communication via ligand-receptor signaling is a fundamental mechanism shaping multicellular organization and functional heterogeneity within tissue microenvironments. Recent advances in spatial tran...
Transposable element-mediated evolutionary expansion of Sox2- and Brn2-binding regulatory modules for mammalian neural-cell differentiation [0.03%]
转座元件介导的Sox2和Brn2结合调控模块的进化扩展以实现哺乳动物神经细胞分化
Hidenori Nishihara,Atsushi Komiya
Hidenori Nishihara
Background: In mammalian genomes, at least several thousand copies of transposable elements (TEs) may function as enhancers or promoters that regulate gene expression, cellular processes, and development. However, it is s...
Benchmarking of sequencing technologies defines optimal strategies for genetic variants detection in a human genome [0.03%]
测序技术的评估定义了人类基因组变异检测中的最优策略
Robert J M Eveleigh,Sarah J Reiling,Jose Hector Galvez et al.
Robert J M Eveleigh et al.
Background: Advances in sequencing technologies continue to improve the resolution and completeness with which human genetic variation can be characterized. Short-read sequencing remains widely used due to its high base a...
Sex and tissue resolved co-expression networks reveal a female placental-brain axis protective against prenatal PCB exposure [0.03%]
性别的组织解剖共表达网络揭示了产后PCB暴露的防护作用的女性胎盘-大脑轴
Kelly H Chau,Kari Neier,Anthony E Valenzuela et al.
Kelly H Chau et al.
Background: Neurodevelopmental disorders have a strong male bias that is poorly understood. The placenta provides molecular information about environmental interactions with genetics (including biological sex) that shape ...
Profiling the transcriptional regulatory network reveals putative shared regulatory elements within homoeologs in polyploid Brassica napus [0.03%]
转录调控网络分析揭示了油菜中同源拷贝内潜在的共享调控元件
Yue Hu,Yupeng Jia,Zhiquan Yang et al.
Yue Hu et al.
Background: Regulatory elements and their interactions underpin transciptional control and are essential for plant growth and development. Yet, in the allopolyploid crop Brassica napus, the global regulatory landscape and...
An integrative single-nucleus multiomic atlas of the human left ventricle identifies gene regulatory network dynamics across cardiac development, aging, and disease [0.03%]
人类左心室整合型单核多组学图谱揭示了心脏发育、衰老和疾病过程中基因调控网络的动态变化
William Gao,Peng Hu,Brittney Wick et al.
William Gao et al.
Background: As the first organ to develop in utero, the human heart undergoes extensive molecular, structural and metabolic remodeling during development and must sustain its function throughout life. ...
Cis-regulatory architecture downstream of FLOWERING LOCUS T underlies quantitative control of flowering in Arabidopsis thaliana [0.03%]
拟南芥FLOWERING LOCUS T下游的顺式调控架构构成了定量开花时间调控的基础
Hao-Ran Zhou,Duong Thi Hai Doan,Thomas Hartwig et al.
Hao-Ran Zhou et al.
Background: The FLOWERING LOCUS T (FT) gene is a central integrator of floral induction in Arabidopsis thaliana, with its precise expression controlled by complex transcriptional networks. While upstream regulatory region...
HistoGWAS: an AI-enabled framework for automated genetic analysis of tissue phenotypes in histology cohorts [0.03%]
基于人工智能的组织表型遗传分析框架HistoGWAS
Shubham Chaudhary,Almut Voigts,Michael Bereket et al.
Shubham Chaudhary et al.
Understanding how genetic variation shapes tissue structure is crucial for disease biology, yet scalable, general-purpose frameworks for genetic analysis of histology traits are lacking. We present HistoGWAS, a framework for genome-wide ass...
The pan-genome provides insights into evolutionary dynamics and fatty acid metabolism in Aceraceae family [0.03%]
泛基因组为 Aceraceae 属的进化动力学和脂肪酸代谢提供见解
Qiuyue Ma,Shushun Li,Zhongping Xu et al.
Qiuyue Ma et al.
Background: The Aceraceae family has ecological, ornamental and economical importance in plants. However, the genetic variations, evolution, and domestication of Aceraceae species are not well understood. Pan-genomes prov...
RNA modification-mediated multidimensional crosstalk: a novel perspective on gene expression regulation [0.03%]
基于RNA修饰的多维度互作网络：基因表达调控的新视角
Yan Wang,Chunxu Yang,Rongjie Lin et al.
Yan Wang et al.
RNA modifications play pivotal roles in regulating RNA metabolism. Notably, they do not function in isolation, but crosstalk with DNA/protein modifications and other RNA modifications to form multi-layered regulatory networks that cooperati...