Convergent evolution of complex structural variants drives therapy resistance in metastatic prostate cancer [0.03%]
趋同进化的复杂结构变异驱动了转移性前列腺癌的耐药性发展
Thaidy Moreno-Rodriguez,Meng Zhang,Arian Lundberg et al.
Thaidy Moreno-Rodriguez et al.
Background: Targeted therapy prolongs the lives of men with metastatic castration-resistant prostate cancer (mCRPC) but mCRPC is ultimately lethal. DNA copy gains that amplify the Androgen Receptor (AR) gene locus are a k...
Single-cell epigenetic and transcriptomic states across the continuum of monoclonal B cell lymphocytosis to chronic lymphocytic leukemia [0.03%]
从单克隆B细胞淋巴细胞增多症到慢性淋巴细胞性白血病的表观遗传和转录组单细胞状态
Anja C Rathgeber,Stacey M Fernandes,Adi Nagler et al.
Anja C Rathgeber et al.
Background: Chronic lymphocytic leukemia (CLL) develops from physiologic B cells through low- and high-count monoclonal B cell lymphocytosis (LC-/HC-MBL). The timing and nature of early B cell expansion and molecular evol...
Lineage-specific evolution, structural diversity, and activity of R2 retrotransposons in animals [0.03%]
动物中的科特氏元件的谱系特异性进化、结构多样性及其活性
Nozhat T Hassan,Briana Van Treeck,Anthony Rodríguez-Vargas et al.
Nozhat T Hassan et al.
Background: Retrotransposons play outsized roles in the evolution of gene regulation, genome function, and disease pathogenesis, and more recently they have sparked interest as instruments for new gene therapy approaches....
Herpes simplex virus type 1 R-loops are targets for APOBEC-mediated mutagenesis [0.03%]
单纯疱疹病毒1型R-loop是APOBEC介导的诱变作用的目标
Márton Miskei,Dóra Varga,Lilla Hornyák et al.
Márton Miskei et al.
APOBEC3 enzymes are key effectors of antiviral immunity that introduce mutations into viral genomes. We show that viral R-loops serve as preferred substrates for APOBEC3-mediated mutagenesis during herpes simplex virus type 1 (HSV-1) infect...
Proteogenomic decoding of chemotherapy resistance in patients with triple-negative breast cancer [0.03%]
三阴性乳腺癌患者化疗耐药的蛋白质基因组解码
Dong Ki Lee,Min Hwan Kim,Yumi Hwang et al.
Dong Ki Lee et al.
Background: The clinical utility of integrated proteogenomic biomarkers for predicting chemotherapy response in triple-negative breast cancer remains underexplored. We prospectively analyzed paired baseline and post-treat...
A sequence knowledge-guided deep learning method for single-cell multi-omics translation [0.03%]
一种序列知识引导的深度学习单细胞多组学数据整合方法
Mengyuan Zhao,Jiawei Li,Yanlin Jiang et al.
Mengyuan Zhao et al.
Background: Analysis of proteins is key to understanding biological processes, disease pathogenesis, and advancing therapeutic development. However, proteome profiling remains significantly limited when compared to the ex...
Experimental and computational methods for allelic imbalance analysis from single-nucleus RNA-seq data [0.03%]
基于单核RNA测序数据进行等位基因不平衡分析的实验和计算方法
Sean K Simmons,Xian Adiconis,Nathan Haywood et al.
Sean K Simmons et al.
Combining allele-specific expression (ASE) analysis with single-cell RNA-seq can elucidate how genomic variation affects RNA expression at the single-cell level. We explore how experimental and computational choices impact the power of ASE-...
DNA damaging properties of G-quadruplex ligand QN-302 are potentiated by the DNA repair inhibitor Olaparib and mitigated by the molecular helicase PhpC [0.03%]
DNA修复抑制剂Olaparib可增强G-四链体配体QN-302的DNA损伤作用，而分子解旋酶PhpC则可以缓解这种损伤作用
Garance Psalmon,Angélique Pipier,Manon Barbotte et al.
Garance Psalmon et al.
Background: QN-302 is a tetra-substituted naphthalene diimide (NDI) designed to bind G-quadruplex (G4) DNA and is in a phase 1 clinical trial for pancreatic ductal adenocarcinoma (PDAC) and other solid tumors. The mechani...
Long-read sequencing identifies aberrant fragmentation patterns linked to elevated cell-free DNA levels in cancer [0.03%]
长读测序识别出了与癌症中细胞游离DNA水平升高相关的异常片段化模式
Benjamin P Berman,Sarah A Erdman,Christina Wheeler et al.
Benjamin P Berman et al.
Background: Altered circulating cell-free DNA (cfDNA) fragmentation patterns serve as cancer biomarkers, yet standard short-read sequencing fails to capture the full fragment-length spectrum. Although cancer patients ofte...
Allelic structural variation at the NLR25-1 locus enhances defense against Pseudomonas syringae in kiwifruit [0.03%]
猕猴桃NLR25-1位点的等位基因结构变异增强了对假单胞菌的抗性
Ying Wu,Yingzhen Wang,Yunzhi Lin et al.
Ying Wu et al.
Background: Canker disease caused by Pseudomonas syringae pv. actinidiae (Psa) poses a major threat to cultivated kiwifruit, and utilization of wild relatives are key to improve resistance. However, comprehensive comparat...