DNA-contact mutant p53 displaces BRCA2 from chromatin and drives R-loop-associated genome instability [0.03%]
DNA结合型突变p53使BRCA2从染色质解离并引发R环相关基因组不稳定性
Fanfan Li,Ke Fang,Shuhan Si et al.
Fanfan Li et al.
Background: Mutations in the tumor suppressor p53 are among the most frequent events in human cancers. Mutant p53 acquires oncogenic activities beyond the loss of tumor suppressive function. However, how different mutatio...
Conserved enhancer association of piRNAs and the implication in germ cell fate surveillance [0.03%]
与piRNA共存的保守性增强子及其在生殖细胞命运监测中的作用
Pin-Jui Kung,Yi-Tzang Tsai,Gabrielle Marie Limpe Chungunco et al.
Pin-Jui Kung et al.
Background: The PIWI-piRNA pathway is crucial for protecting genomic integrity from derepressed transposon invasion in developing germ cells after genome-wide epigenetic erasure. While extensive mouse studies show that pr...
Global genetic dissection of maize-teosinte divergence reveals EL3-2 as a pleiotropic domestication regulator [0.03%]
全球遗传解剖发现EL3-2基因是玉米 Domestication(人工培育)过程中的关键基因
Renyu Zhang,Xuan Zhang,Shenshen Wu et al.
Renyu Zhang et al.
Background: Understanding the genetic basis of trait divergence between maize and its wild progenitor teosinte is critical for elucidating crop domestication processes and accelerating maize improvement. This divergence i...
Pan-cell type continuous chromatin state annotation of all epigenomes from the International Human Epigenome Consortium [0.03%]
国际人类表观基因组联盟所有表观基因组的全细胞类型连续染色质状态注释
Habib Daneshpajouh,Ismail Moghul,Kay C Wiese et al.
Habib Daneshpajouh et al.
Background: The International Human Epigenome Consortium has generated thousands of datasets profiling transcription factor binding, histone modification, and DNA accessibility. Existing segmentation and annotation approa...
MicNet: integrating spatially resolved transcriptomes and pathology images by contrastive deep neural network [0.03%]
MicNet：通过对比深度神经网络整合空间解析转录组和病理图像
Shidan Wang,Qin Zhou,Yuansheng Zhou et al.
Shidan Wang et al.
Recent breakthroughs in spatially resolved transcriptomic technologies have enabled molecular characterization of cells while preserving spatial and morphological contexts. However, integrating transcriptomic profiles and pathology images r...
Metabolic disease variants rewire gene regulation through disruption of DNA G-quadruplex structures [0.03%]
代谢性疾病变异通过破坏DNA G-四链体结构重新构建基因调控网络
Angelika Lahnsteiner,Victoria Ellmer,Esther Schönauer et al.
Angelika Lahnsteiner et al.
Background: The global prevalence of metabolic diseases (MetDs) continues to rise and is associated with an increased cancer risk. Genome-wide association studies have identified numerous single nucleotide variants (SNVs)...
Genome-wide association and MaODR-based multi-locus interaction analyses reveal a susceptibility gene network for newly identified metabolic syndrome [0.03%]
全基因组关联和MaODR-Based多基因位点相互作用分析鉴定出一组新的代谢综合征易感基因网络
Yu-Da Lin,Kuei-Hau Luo,Li-Yeh Chuang et al.
Yu-Da Lin et al.
Background: Metabolic syndrome involves several lipid-related genes, including apolipoprotein A5 (APOA5), lipoprotein lipase (LPL), and cholesteryl ester transfer protein (CETP). Although individual SNP susceptibility has...
Publisher Correction: Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants [0.03%]
publisher correction: 在 44,287 名多祖先参与者中分析肺功能和慢性阻塞性肺疾病的全基因组序列
Wonji Kim,Xiaowei Hu,Kangjin Kim et al.
Wonji Kim et al.
Published Erratum
Genome biology. 2026 Jun 9;27(1):189. DOI:10.1186/s13059-026-04141-8 2026
DNA methylation-based immune cell profiling in mouse blood using MouseRS-CMD [0.03%]
基于DNA甲基化的免疫细胞谱分析：小鼠血液中CMD的MouseRS检测法
Samuel R Reynolds,Hannah G Stolrow,Min Kyung Lee et al.
Samuel R Reynolds et al.
We present MouseRS-CMD, a murine DNA methylation-based immune cell deconvolution tool. Neutrophils, monocytes, natural killer cells, B cells, CD4 + and CD8 + T cells were purified. DNA methylation was measured with the Illumina Mouse Methyl...
TestNet: a method for inferring microbial networks with false discovery rate control for clustered and unclustered samples [0.03%]
测试微生物网络推断方法及聚类和非聚类样本的假发现率控制
Chang Su,Yicong Mao,Mengyu He et al.
Chang Su et al.
Most existing methods for inferring microbial networks generate only point estimates of Pearson's correlations without assessing their significance, and none accounts for clustering. We introduce TestNet, a novel method that delivers well-c...