Spatial and single-cell expression analyses reveal complex expression domains in early wheat spike development [0.03%]
空间和单细胞表达分析揭示了小麦穗发育早期复杂的表达区域
Xiaosa Xu,Huiqiong Lin,Junli Zhang et al.
Xiaosa Xu et al.
Background: Wheat is important for global food security. Understanding the molecular mechanisms driving spike and spikelet development can benefit the development of more productive varieties. ...
iPro-MP: a BERT-based model to predict multiple prokaryotic promoters [0.03%]
基于BERT的预测原核生物启动子的模型:iPro-MP
Wei Su,Yuhe Yang,Yafei Zhao et al.
Wei Su et al.
Background: Promoters, as essential cis-regulatory elements in prokaryotes, govern gene expression by mediating RNA polymerase binding through core motifs and long-range regulatory interactions, playing a pivotal role in ...
A novel gene expression stability metric to unveil homeostasis and regulation [0.03%]
一种新的基因表达稳定性度量方法用于揭示稳态和调节机制
Mengjie Chen
Mengjie Chen
We explore the concept of gene expression stability within a homeostatic cell through the gene homeostasis Z-index, a measure that highlights genes under active regulation in response to internal and external stimuli. The Z-index uncovers d...
Engineered virus-like particle-assembled Vegfa-targeting Cas9 ribonucleoprotein treatment alleviates neovascularization in wet age-related macular degeneration [0.03%]
工程化的病毒样颗粒组装的靶向Vegfa的Cas9核糖核蛋白治疗可减轻湿性年龄相关性黄斑变性的新生血管化
Jun Wu,Hyewon Jang,Hyunjong Kwak et al.
Jun Wu et al.
Background: Age-related macular degeneration, particularly the wet form, is a leading cause of vision loss, characterized by vascular endothelial growth factor A (VEGFA) overproduction. Engineered virus-like particles (eV...
Multi-omics insights into microbiome-rumen epithelium interaction mechanisms underlying subacute rumen acidosis tolerance in dairy goats [0.03%]
多组学视角下微生物群-皱胃上皮相互作用机制在奶山羊亚急性皱胃酸中毒中的作用研究
Jingyi Xu,Xiaodong Chen,Jianrong Ren et al.
Jingyi Xu et al.
Background: To address rising demand for dairy products, dairy goats are often fed high-concentrate diets, which lead to subacute rumen acidosis (SARA). The mechanisms behind individual variation in SARA tolerance are not...
GIMIC: smoothed graph-image representation of microbiome samples induce an optimal distance [0.03%]
用于微生物组样品的平滑图像表示可诱导最佳距离GIMIC模型
Oshrit Shtossel,Yoram Louzoun
Oshrit Shtossel
An essential tool in microbiome is the distance between samples. This serves to detect groups of similar samples. We have recently shown that combining the cladogram with the abundance of each microbe into a sorted normalized abundance tree...
Evaluating the potential and limitations of nanopore adaptive sampling for targeted transcriptome sequencing [0.03%]
纳米孔自适应采样技术在靶向转录组测序中的潜力与局限性评估
Nicole DeBruyne,Feng Wang,Yang Xu et al.
Nicole DeBruyne et al.
Long-read RNA sequencing is a powerful technology for transcriptomics, but low throughput and high cost pose challenges. Adaptive sampling, a feature of Oxford Nanopore Technologies, offers real-time enrichment by selectively ejecting non-t...
Author Correction: MOADE: a multimodal autoencoder for dissociating bulk multi-omics data [0.03%]
作者更正：MOADE：一种多模态自动编码器用于分离多种组学数据的总体信息
Jiao Sun,Ayesha A Malik,Tong Lin et al.
Jiao Sun et al.
Published Erratum
Genome biology. 2025 Oct 9;26(1):348. DOI:10.1186/s13059-025-03826-w 2025
A molecular census to elucidate the demixing mechanism of membraneless organelles [0.03%]
一种分子普查，阐明膜-less细胞器的分相机制
Cheryn Ali,Fernando Muzzopappa,Fabian Erdel
Cheryn Ali
Background: Cells contain membraneless organelles that have been proposed to form via phase separation involving dense networks of multivalent intermolecular interactions. As it is notoriously difficult to experimentally ...
Agnieszka P Lipinska,Guillaume Cossard,Paul Epperlein et al.
Agnieszka P Lipinska et al.
Background: Sex chromosomes in red algae have remained relatively understudied, despite their fundamental role in understanding the evolution of sex determination across eukaryotes. In this study, we investigate the struc...