GPU-accelerated linkage disequilibrium scans reveal non-independent assortment of human non-homologous chromosomes [0.03%]
基于GPU加速的连锁不平衡扫描揭示了人类非同源染色体之间的非独立分离现象
Wenhua Lv,Yuping Zou,Zhenwei Shang et al.
Wenhua Lv et al.
Background: The independence of assortment between loci on non‑homologous chromosomes, as proposed by Mendel's laws, has not been rigorously validated at the whole‑genome scale due to the computational demands of estima...
Benchmarking Hi-C scaffolders using reference genomes and de novo assemblies [0.03%]
参考基因组和从头组装的Hi-C支架基准测试
Aakash Sur,William Stafford Noble,Peter J Myler
Aakash Sur
Background: Studying a new species using high-throughput sequencing requires a high-quality reference genome. However, assembling chromosome length sequences remains challenging. Recent advances in chromatin conformation ...
Evaluating the performance of ancient DNA genetic relatedness estimation methods using high-fidelity pedigree simulations [0.03%]
利用高保真 pedigrees 模拟评估古DNA遗传关系估计方法性能
Maël Lefeuvre,Marie-Claude Marsolier,Céline Bon
Maël Lefeuvre
Background: Recent advancements in paleogenetics, coupled with the emergence of dedicated statistical methods have, in recent years, streamlined the detection of close genetic ties from ancient DNA samples, leading to a s...
Endogenous retroviral elements LTR8B and MER65 rewire PSG9 regulation to control trophoblast syncytialization and pre-eclampsia risk [0.03%]
内源性逆转录病毒元件LTR8B和MER65通过重新调控PSG9来控制合体滋养层的融合以及子痫前期的风险
Manvendra Singh,Yuliang Qu,Amit Pande et al.
Manvendra Singh et al.
Background: Understanding the causes of the exceptional rate of evolution of the mammalian placenta is likely to aid the understanding of placental development and the etiology of the human-specific pregnancy disorder pre...
Tribolium madens satellitome reveals a network of highly abundant satellite DNAs in megabase-sized regions hallmarked by macro-dyad symmetries [0.03%]
拟步甲Tribolium madens的卫星序列组揭示了大型对称结构中的高度丰富的卫星DNA网络
Damira Veseljak,Evelin Despot-Slade,Marin Volarić et al.
Damira Veseljak et al.
Background: Tandemly repeated satellite DNAs (satDNAs) are among the most copious sequences of eukaryotic genomes. They often reside in centromeric regions, but their diversity among different organisms obscures the prope...
Augmented CENH3 loading is accompanied by transcriptional and epigenetic reprogramming at rice centromeres during meiosis [0.03%]
在水稻减数分裂过程中，伴随CENH3加载增强子，中心粒区域转录和表观遗传重编程
Lei Cao,Yangzi Zhao,Hanli You et al.
Lei Cao et al.
Background: Centromere identity in eukaryotes is defined epigenetically by CENH3 (CENPA), a specialized histone H3 variant essential for kinetochore establishment and faithful chromosome segregation. However, the regulato...
Systematic investigation of interindividual variation of DNA methylation in human whole blood [0.03%]
人类全血DNA甲基化个体差异的系统研究
Olivia A Grant,Meena Kumari,Leonard Schalkwyk et al.
Olivia A Grant et al.
Background: Interindividual genetic variability is well characterised, but we still lack a complete catalogue of loci displaying variable and stable epigenetic patterns. ...
Ivan Tolstoganov,Marcel Martin,Nicolas Buchin et al.
Ivan Tolstoganov et al.
A key step in sequence similarity search is to identify shared seeds between a query and a reference sequence. A well-known tradeoff is that longer seeds offer fast searches but reduce sensitivity in variable regions. We introduce multi-con...
Decoding exon inclusion in the human brain reveals more divergent splicing mechanisms in neurons than glia [0.03%]
人类大脑中外显子包含的解码显示神经元中的剪接机制比星形胶质细胞更具有多样性
Lieke Michielsen,Justine Hsu,Anoushka Joglekar et al.
Lieke Michielsen et al.
Background: Alternative splicing contributes to molecular diversity across brain cell types. RNA-binding proteins (RBPs) regulate splicing, but the genome-wide mechanisms underlying cell-type-specific splicing remain poor...
Centromere organization and epigenetic regulation in Aristolochia fimbriata [0.03%]
Aristolochia fimbriata 的着丝粒组织与表观遗传调控
Kunpeng Li,Jie Li,Ran Zhao et al.
Kunpeng Li et al.
Background: Aristolochia fimbriata (A. fimbriata), a magnoliid species similar to Amborella trichopoda, has not undergone additional whole genome duplications since the origin of extant flowering plants. Due to its low ge...