CENP-A/CENP-B uncoupling in the evolutionary reshuffling of centromeres in equids [0.03%]
马科动物进化过程中组蛋白变异导致的端粒重排
Eleonora Cappelletti,Francesca M Piras,Marialaura Biundo et al.
Eleonora Cappelletti et al.
Background: While CENP-A is the epigenetic determinant of the centromeric function, the role of CENP-B, a centromeric protein binding a specific DNA sequence, the CENP-B-box, remains elusive. In the few mammalian species ...
SETD2 loss-of-function uniquely sensitizes cells to epigenetic targeting of NSD1-directed H3K36 methylation [0.03%]
表观遗传靶向NSD1介导的H3K36甲基化的细胞敏感性依赖于SETD2功能丧失
Ryan T Wagner,Ryan A Hlady,Xiaoyu Pan et al.
Ryan T Wagner et al.
Background: SETD2 is the sole epigenetic factor responsible for catalyzing histone 3, lysine 36, tri-methylation (H3K36me3) in mammals. Its role in regulating cellular processes such as RNA splicing, DNA repair, and spuri...
MAAT: a new nonparametric Bayesian framework for incorporating multiple functional annotations in transcriptome-wide association studies [0.03%]
MAAT：一种新的非参数贝叶斯框架，用于在转录组范围的关联研究中结合多个功能注释
Han Wang,Xiang Li,Teng Li et al.
Han Wang et al.
Transcriptome-wide association study (TWAS) has emerged as a powerful tool for translating the myriad variations identified by genome-wide association studies (GWAS) into regulated genes in the post-GWAS era. While integrating annotation in...
A novel decomposer-exploiter interaction framework of plant residue microbial decomposition [0.03%]
植物残体微生物分解的新型分解者-利用者相互作用框架
Youzhi Miao,Wei Wang,Huanhuan Xu et al.
Youzhi Miao et al.
Background: Plant residue microbial decomposition, subject to significant environmental regulation, represents a crucial ecological process shaping and cycling the largest terrestrial soil organic carbon pool. However, th...
Engineering a bacterial toxin deaminase from the DYW-family into a novel cytosine base editor for plants and mammalian cells [0.03%]
工程化DYW家族细菌毒素脱氨酶为植物和哺乳动物细胞的新型胞嘧啶碱基编辑器
Dingbo Zhang,Fiona Parth,Laura Matos da Silva et al.
Dingbo Zhang et al.
Base editors are precise editing tools that employ deaminases to modify target DNA bases. The DYW-family of cytosine deaminases is structurally and phylogenetically distinct and might be harnessed for genome editing tools. We report a novel...
Multi-INTACT: integrative analysis of the genome, transcriptome, and proteome identifies causal mechanisms of complex traits [0.03%]
多INTACT：基因组、转录组和蛋白质组的综合分析可识别复杂性状的因果机制
Jeffrey Okamoto,Xianyong Yin,Brady Ryan et al.
Jeffrey Okamoto et al.
We present multi-integration of transcriptome-wide association studies and colocalization (Multi-INTACT), an algorithm that models multiple "gene products" (e.g., encoded RNA transcript and protein levels) to implicate causal genes and rele...
A fully phased octoploid strawberry genome reveals the evolutionary dynamism of centromeric satellites [0.03%]
一个完全相位的八倍体草莓基因组揭示了着丝粒卫星的进化动力学
Xin Jin,Haiyuan Du,Maoxian Chen et al.
Xin Jin et al.
We systematically examine the application of different phasing strategies to decrypt strawberry genome organization and produce a fully phased and accurate reference genome for Fragaria x ananassa cv. "EA78" (2n = 8x = 56). We identify 147 ...
Author Correction: X-Mapper: fast and accurate sequence alignment via gapped x-mers [0.03%]
作者更正：X-Mapper：通过带缺口的x-核苷酸进行快速而准确的序列比对
Jeffry M Gaston,Eric J Alm,An-Ni Zhang
Jeffry M Gaston
Published Erratum
Genome biology. 2025 Jan 27;26(1):16. DOI:10.1186/s13059-025-03481-1 2025
Dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes [0.03%]
非洲慈鲷中转座元件和piRNA通路的动态协同共进化
Miguel Vasconcelos Almeida,Moritz Blumer,Chengwei Ulrika Yuan et al.
Miguel Vasconcelos Almeida et al.
Background: East African cichlid fishes have diversified in an explosive fashion, but the (epi)genetic basis of the phenotypic diversity of these fishes remains largely unknown. Although transposable elements (TEs) have b...
MaveDB 2024: a curated community database with over seven million variant effects from multiplexed functional assays [0.03%]
MaveDB 2024：一个经过社区整理的数据库，包含来自多重功能测定的逾七百万种变异效应
Alan F Rubin,Jeremy Stone,Aisha Haley Bianchi et al.
Alan F Rubin et al.
Multiplexed assays of variant effect (MAVEs) are a critical tool for researchers and clinicians to understand genetic variants. Here we describe the 2024 update to MaveDB ( https://www.mavedb.org/ ) with four key improvements to the MAVE co...