Evaluating the representational power of pre-trained DNA language models for regulatory genomics [0.03%]
评估预训练DNA语言模型在调控基因组学中表征能力的大小
Ziqi Tang,Nirali Somia,Yiyang Yu et al.
Ziqi Tang et al.
Background: The emergence of genomic language models (gLMs) offers an unsupervised approach to learning a wide diversity of cis-regulatory patterns in the non-coding genome without requiring labels of functional activity ...
G-quadruplex structures regulate long-range transcriptional reprogramming to promote drug resistance in ovarian cancer cells [0.03%]
G-四链体结构通过调控远程基因重编程促进卵巢癌细胞耐药性生成
Jenna Robinson,Gem Flint,Ian Garner et al.
Jenna Robinson et al.
Background: Epigenetic evolution is a common mechanism used by cancer cells to evade the therapeutic effects of drug treatment. In ovarian cancers, epigenetically driven resistance is thought to be responsible for many la...
DNA 5mC methylation inhibits the formation of G-quadruplex structures in the genome [0.03%]
DNA 5mC甲基化可抑制基因组中G-四链体的形成
Kangkang Niu,Lijun Xiang,Xiaojuan Zhang et al.
Kangkang Niu et al.
Background: G-quadruplex structures (G4s) have been identified in the genomes of many organisms and have been proven to play significant epigenetic regulatory roles in gene transcription. Intriguingly, only a small portio...
Admixed and single-continental genome segments of the same ancestry have distinct linkage disequilibrium patterns [0.03%]
杂交和单一大陆的同一祖先基因组片段具有不同的链锁不平衡模式
Hanbin Lee,Moo Hyuk Lee,Kangcheng Hou et al.
Hanbin Lee et al.
Background: Admixed populations offer valuable insight into the genetic architecture of complex traits. Many studies have proposed methods for genome-wide association study (GWAS) in admixed populations and various simula...
Protein quantitative trait locus analysis in African American and non-Hispanic White individuals [0.03%]
非洲裔美国人和非西班牙裔白人的蛋白质数量性状位点分析
Yanwei Cai,Mari Johnson,Jeffrey Haessler et al.
Yanwei Cai et al.
Background: Substantial efforts have been dedicated to exploring the link between genetic regulation and the proteome, informing studies of complex trait mechanisms. Most of these efforts have been limited to populations ...
T-DNAreader: fast and precise identification of T-DNA insertion sites in plant genomes using RNA sequencing data [0.03%]
基于RNA测序数据的植物基因组中T-DNA插入位点的快速精确定位工具T-DNA reader
Hongwoo Lee,Pil Joon Seo
Hongwoo Lee
Agrobacterium-mediated plant transformation, which enables the delivery of DNA using transfer DNA (T-DNA) binary vectors, is an essential technique in plant research. T-DNAs randomly integrate into the host genome, and multiple T-DNAs can s...
Long-term DNA methylation changes mediate heterologous cytokine responses after BCG vaccination [0.03%]
卡介苗接种后的长期DNA甲基化变化可介导异源细胞因子反应
Cancan Qi,Zhaoli Liu,Gizem Kilic et al.
Cancan Qi et al.
Background: Epigenetic reprogramming shapes immune memory in both innate (trained immunity) and adaptive immune cells following Bacillus Calmette-Guérin (BCG) vaccination. However, the role of dynamic DNA methylation cha...
Comprehensive protein datasets and benchmarking for liquid-liquid phase separation studies [0.03%]
用于液-液相分离研究的全面蛋白质数据集及基准测试
Carlos Pintado-Grima,Oriol Bárcenas,Eva Arribas-Ruiz et al.
Carlos Pintado-Grima et al.
Background: Proteins self-organize in dynamic cellular environments by assembling into reversible biomolecular condensates through liquid-liquid phase separation (LLPS). These condensates can comprise single or multiple p...
Cell cycle-dependent TICRR/TRESLIN and MTBP chromatin binding mechanisms and patterns [0.03%]
细胞周期依赖的TICRR/TRESLIN和MTBP染色质结合机制与模式
Tyler D Noble,Courtney G Sansam,Kimberlie A Wittig et al.
Tyler D Noble et al.
Background: The selection of replication origins is a defining characteristic of DNA replication in eukaryotes, yet its mechanism in humans has not been well defined. Potential DNA replication origins are licensed through...
A genome-wide association study integrated with single-cell and bulk profiles uncovers susceptibility genes for nasopharyngeal carcinoma involved in tumorigenesis via regulation of T cells [0.03%]
整合单细胞和批量谱型的全基因组关联研究发现鼻咽癌致病易感基因
Tong-Min Wang,Wen-Li Zhang,Jin-Ru Xie et al.
Tong-Min Wang et al.
Background: Nasopharyngeal carcinoma is an aggressive malignancy originating from the nasopharyngeal mucosa and associated with genetic factors. Many nasopharyngeal carcinoma susceptibility loci have been identified by ge...