STHD: probabilistic cell typing of single spots in whole transcriptome spatial data with high definition [0.03%]
基于单点概率细胞类型的高精度全转录组空间数据细胞亚型鉴定算法研究
Chuhanwen Sun,Yi Zhang
Chuhanwen Sun
Recent advances in spatial transcriptomics technologies have enabled gene expression profiling across the transcriptome in spots with subcellular resolution, but high sparsity and dimensionality present significant computational challenges....
Direct genetic transformation bypasses tumor-associated DNA methylation alterations [0.03%]
直接基因转化绕过了与肿瘤相关的DNA甲基化改变
Sara Hetzel,Eran Hodis,Elena Torlai Triglia et al.
Sara Hetzel et al.
Background: Tumors represent dynamically evolving populations of mutant cells, and many advances have been made in understanding the biology of their progression. However, there are key unresolved questions about the cond...
Sceptic: pseudotime analysis for time-series single-cell sequencing and imaging data [0.03%]
Skeptic：时间序列单细胞测序和成像数据的伪时间分析
Gang Li,Hyeon-Jin Kim,Sriram Pendyala et al.
Gang Li et al.
Several computational methods have been developed to construct single-cell pseudotime embeddings for extracting the temporal order of transcriptional cell states from time-series scRNA-seq datasets. However, existing methods suffer from low...
scPDA: denoising protein expression in droplet-based single-cell data [0.03%]
基于droplet的单细胞数据去噪蛋白质表达.scPDA
Ouyang Zhu,Jun Li
Ouyang Zhu
Droplet-based profiling techniques such as CITE-seq are often contaminated by technical noise. Current computational denoising methods have serious limitations, including a strong reliance on often-unavailable empty droplets or null control...
Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease [0.03%]
基于56,241人的跨祖先队列的全基因组元分析鉴定出已知和新的阿尔茨海默病风险位点
Farid Rajabli,Penelope Benchek,Giuseppe Tosto et al.
Farid Rajabli et al.
Background: Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in ancestry groups of predominantly non-European ancestral background in genome-wide association studies (GWAS). We c...
Meta-Analysis
Genome biology. 2025 Jul 17;26(1):210. DOI:10.1186/s13059-025-03564-z 2025
HELLS is required for maintaining proper DNA modification at human satellite repeats [0.03%]
HELLS在维持人类卫星重复序列适当的DNA修饰中是必需的
Philine Guckelberger,Leah Haut,Rosaria Tornisiello et al.
Philine Guckelberger et al.
DNA methylation regulation involves multi-layered chromatin interactions that require remodeling proteins like the helicase, lymphoid-specific (HELLS). Here, we generate HELLS and DNA methyltransferase 3A and B (DNMT3A/B) knockout human plu...
Heather J Zhou,Xinzhou Ge,Jingyi Jessica Li
Heather J Zhou
A central task in expression quantitative trait locus analysis is to identify cis-eGenes, i.e., genes whose expression levels are regulated by at least one local genetic variant. Existing cis-eGene identification methods are either computat...
The genomic footprints of migration: how ancient DNA reveals our history of mobility [0.03%]
遗传痕迹：古DNA揭示了我们迁徙的历史
Matthew P Williams,Christian D Huber
Matthew P Williams
Ancient DNA has emerged as a powerful tool for studying human migration through the detection of admixture signatures. Here, we present the theoretical principles and methodologies for admixture analysis, with an emphasis on f-statistics an...
ZSCAN4 functions as a safeguard to maintain centromere integrity during oocyte meiosis [0.03%]
ZSCAN4在卵子减数分裂过程中作为维持着丝粒完整性的保护因子发挥作用
Da Yi Choi,Jiyeon Leem,Crystal Lee et al.
Da Yi Choi et al.
Background: Centromeres play a vital role in ensuring accurate chromosome segregation during meiosis by serving as the foundation for kinetochore assembly and microtubule attachment. In oocytes, maintaining centromere int...
Ting Wu,Hang-Xu Zhou,Jing Tian et al.
Ting Wu et al.
Background: It is crucial to investigate protein functions in specific subcellular environments. Cross-linking mass spectrometry is a powerful tool to map the direct interactome of proteins by identifying inter-protein cr...