Purifying selection shapes the dynamics of P-element invasion in Drosophila simulans populations [0.03%]
净化选择决定Drosophila simulans种群中P元素入侵的动力学过程
Anna M Langmüller,Benjamin C Haller,Viola Nolte et al.
Anna M Langmüller et al.
Background: Transposable elements (TEs) are DNA sequences that can move within a host genome. Many new TE insertions have deleterious effects on their host and are therefore removed by purifying selection. The genomic dis...
Comprehensive genomic and phenotypic analyses reveal the genetic basis of fruit quality in litchi [0.03%]
对荔枝果实品质的全基因组和表型综合分析揭示了其遗传基础
Qian Yan,Junting Feng,Jiezhen Chen et al.
Qian Yan et al.
Background: Litchi, an economically important fruit crop in Southeast Asia, is renowned for its distinctive flavor and nutrient value, but its genetic diversity and genetic basis underlying fruit quality regulation remain...
Explainable deep learning for stratified medicine in inflammatory bowel disease [0.03%]
深度学习在炎症性肠病分层医学中的可解释性研究
Nora Verplaetse,Piero Fariselli,Yves Moreau et al.
Nora Verplaetse et al.
Moving from a one-size-fits-all to an individual approach in precision medicine requires a deeper understanding of disease molecular mechanisms. Especially in heterogeneous complex diseases such as inflammatory bowel disease (IBD), better m...
Modeling combinatorial regulation from single-cell multi-omics provides regulatory units underpinning cell type landscape using cRegulon [0.03%]
基于单细胞多组学的组合调控建模利用cRegulon提供细胞类型景观背后的调节单元
Zhanying Feng,Xi Chen,Zhana Duren et al.
Zhanying Feng et al.
Advances in single-cell technology enable large-scale generation of omics data, promising for clarifying gene regulatory networks governing different cell type/states. Nonetheless, prevailing methods fail to account for universal and reusab...
Joint representation and visualization of derailed cell states with Decipher [0.03%]
利用Decipher对脱轨细胞状态的联合表示和可视化
Achille Nazaret,Joy Linyue Fan,Vincent-Philippe Lavallée et al.
Achille Nazaret et al.
Biological insights often depend on comparing conditions such as disease and health. Yet, we lack effective computational tools for integrating single-cell genomics data across conditions or characterizing transitions from normal to deviant...
A base editing platform for the correction of cancer driver mutations unmasks conserved p53 transcription programs [0.03%]
基于编辑的癌症驱动突变矫正平台揭示了保守的p53转录程序
Pascal Wang,Rituparno Sen,Frank Buchholz et al.
Pascal Wang et al.
Background: Understanding the role of cancer hotspot mutations is essential for unraveling mechanisms of tumorigenesis and identifying therapeutic vulnerabilities. Correcting cancer mutations with base editing is a novel,...
HebQTLs reveal intra-subgenome regulation inducing unbalanced expression and function among bread wheat homoeologs [0.03%]
HebQTLs揭示了诱导一维表达和功能的面包小麦同源学调节不平衡的亚基因组 регуляция
Xiaoming Wang,Yuxiu Liu,Peng Zhao et al.
Xiaoming Wang et al.
Background: Polyploidy contains multiple gene copies, known as homoeologs. Differential expression of homoeologs confers expression plasticity and facilitates the adaptation and domestication of major polyploid crops. How...
FedscGen: privacy-preserving federated batch effect correction of single-cell RNA sequencing data [0.03%]
FedscGen：单细胞RNA测序数据的隐私保护联合批次效应校正
Mohammad Bakhtiari,Stefan Bonn,Fabian Theis et al.
Mohammad Bakhtiari et al.
Single-cell RNA-seq data from clinical samples often suffer from batch effects, but data sharing is limited due to genomic privacy concerns. We present FedscGen, a privacy-preserving communication-efficient federated method built upon the s...
Irene Perotti,Laura Broglia,Gian Gaetano Tartaglia et al.
Irene Perotti et al.
X-chromosome inactivation (XCI) is a crucial mechanism of dosage compensation in female mammals ensuring that genes from only one X chromosome are expressed, initiated through expression of the long noncoding RNA Xist. Recent evidence under...
Epigenetic priming of mammalian embryonic enhancer elements coordinates developmental gene networks [0.03%]
表观遗传学预示哺乳动物胚胎增强子元件协调发育基因网络
Christopher D Todd,Jannat Ijaz,Fereshteh Torabi et al.
Christopher D Todd et al.
Background: Embryonic development requires the accurate spatiotemporal execution of cell lineage-specific gene expression programs, which are controlled by transcriptional enhancers. Developmental enhancers adopt a primed...