mRNA m6A regulates gene expression via H3K4me3 shift in 5' UTR [0.03%]
mRNA的m6A通过在5'UTR上移动H3K4me3来调控基因表达
Yuna Yang,Yuqing Huang,Tian Wang et al.
Yuna Yang et al.
Background: N6-methyladenosine (m6A) is a prevalent and conserved RNA modification in eukaryotes. While its roles in the 3' untranslated regions (3' UTR) are well-studied, its role in the 5' UTR and its relationship with ...
Single-cell RNA-seq data have prevalent blood contamination but can be rescued by Originator, a computational tool separating single-cell RNA-seq by genetic and contextual information [0.03%]
单细胞RNA序列数据普遍存在血液污染，但可以被Originator rescue，这是一种通过遗传和背景信息分离单细胞RNA序列的计算工具。
为了更符合中文表达习惯，可以优化为：
单细胞RNA序列数据普遍受血液污染，可通过计算工具Originator基于遗传与背景信息进行修正。
Thatchayut Unjitwattana,Qianhui Huang,Yiwen Yang et al.
Thatchayut Unjitwattana et al.
Single-cell RNA sequencing (scRNA-seq) data from complex human tissues have prevalent blood cell contamination during the sample preparation process. They may also comprise cells of different genetic makeups. We propose a new computational ...
Recruitment and rejoining of remote double-strand DNA breaks for enhanced and precise chromosome editing [0.03%]
远程双链DNA断裂的招募和重新连接以提高和精确染色体编辑
Mingyao Wang,Pengchong Fu,Ziheng Chen et al.
Mingyao Wang et al.
Chromosomal rearrangements, such as translocations, deletions, and inversions, underlie numerous genetic diseases and cancers, yet precise engineering of these rearrangements remains challenging. Here, we present a CRISPR-based homologous r...
Yang Qiu,Lifen Liu,Jiali Yan et al.
Yang Qiu et al.
Background: Identifying transcriptional cis-regulatory elements (CREs) and understanding their role in gene expression are essential for the precise manipulation of gene expression and associated phenotypes. This knowledg...
Trans-ancestral rare variant association study with machine learning-based phenotyping for metabolic dysfunction-associated steatotic liver disease [0.03%]
与代谢功能障碍相关脂肪肝疾病机器学习表型的跨祖先罕见变异关联研究
Robert Chen,Ben Omega Petrazzini,Áine Duffy et al.
Robert Chen et al.
Background: Genome-wide association studies (GWAS) have identified common variants associated with metabolic dysfunction-associated steatotic liver disease (MASLD). However, rare coding variant studies have been limited b...
Meta-Analysis
Genome biology. 2025 Mar 10;26(1):50. DOI:10.1186/s13059-025-03518-5 2025
DAGIP: alleviating cell-free DNA sequencing biases with optimal transport [0.03%]
DAGIP：用最优传输缓解无细胞DNA序列偏见
Antoine Passemiers,Stefania Tuveri,Tatjana Jatsenko et al.
Antoine Passemiers et al.
Cell-free DNA (cfDNA) is a rich source of biomarkers for various pathophysiological conditions. Preanalytical variables, such as the library preparation protocol or sequencing platform, are major confounders of cfDNA analysis. We present DA...
Genome assembly of the maize B chromosome provides insight into its epigenetic characteristics and effects on the host genome [0.03%]
玉米B染色体的基因组装为其表观遗传特性及其对宿主基因组的影响提供了见解
Qian Liu,Yang Liu,Congyang Yi et al.
Qian Liu et al.
Background: B chromosomes contribute to the genetic variation in numerous eukaryotes. Yet their genetic and epigenetic characteristics, as well as their effects on the host genome remain poorly understood. ...
Ultra-sensitive detection of transposon insertions across multiple families by transposable element display sequencing [0.03%]
转座子显示测序对多个家族转座子插入的超灵敏检测
Pol Vendrell-Mir,Basile Leduque,Leandro Quadrana
Pol Vendrell-Mir
Background: Mobilization of transposable elements (TEs) can generate large effect mutations. However, due to the difficulty of detecting new TE insertions in genomes and the typically rare occurrence of transposition, the...
Benchmarking single-cell cross-omics imputation methods for surface protein expression [0.03%]
单细胞交叉组学插补方法在表面蛋白表达方面的基准测试
Chen-Yang Li,Yong-Jia Hong,Bo Li et al.
Chen-Yang Li et al.
Background: Recent advances in single-cell multimodal omics sequencing have facilitated the simultaneous profiling of transcriptomes and surface proteomes within individual cells, offering insights into cellular functions...
Josep Biayna,Gabrijela Dumbović
Josep Biayna
Eukaryotic cells are highly structured and composed of multiple membrane-bound and membraneless organelles. Subcellular RNA localization is a critical regulator of RNA function, influencing various biological processes. At any given moment,...