Global profiling of CPL3-mediated alternative splicing reveals regulatory mechanisms of DGK5 in plant immunity and phosphatidic acid homeostasis [0.03%]
全局分析CPL3介导的选择性剪接揭示DGK5在植物免疫和磷脂酸稳态中的调控机制
Sung-Il Kim,Xiyu Ma,Liang Kong et al.
Sung-Il Kim et al.
Background: Alternative splicing of precursor mRNAs serves as a crucial mechanism to enhance gene expression plasticity for organismal adaptation. However, the precise regulation and function of alternative splicing in pl...
Analysis of 30 chromosome-level Drosophila genome assemblies reveals dynamic evolution of centromeric satellite repeats [0.03%]
对30个染色体级别的果蝇基因组装的分析揭示了着丝粒卫星重复动态演变的过程
Daniel Gebert,Amir D Hay,Jennifer P Hoang et al.
Daniel Gebert et al.
Background: The Drosophila genus is ideal for studying genome evolution due to its relatively simple chromosome structure and small genome size, with rearrangements mainly restricted to within chromosome arms, such as Mul...
Widespread impact of transposable elements on the evolution of post-transcriptional regulation in the cotton genus Gossypium [0.03%]
可移动元件对棉属Gossypium转录后调控进化产生的广泛影响
Xuehan Tian,Ruipeng Wang,Zhenping Liu et al.
Xuehan Tian et al.
Background: Transposable element (TE) expansion has long been known to mediate genome evolution and phenotypic diversity in organisms, but its impact on the evolution of post-transcriptional regulation following species d...
Exploring and mitigating shortcomings in single-cell differential expression analysis with a new statistical paradigm [0.03%]
探索并缓解单细胞差异表达分析中的不足的新统计范式
Chih-Hsuan Wu,Xiang Zhou,Mengjie Chen
Chih-Hsuan Wu
Background: Differential expression analysis is pivotal in single-cell transcriptomics for unraveling cell-type-specific responses to stimuli. While numerous methods are available to identify differentially expressed gene...
The haplotype-resolved genome assembly of an ancient citrus variety provides insights into the domestication history and fruit trait formation of loose-skin mandarins [0.03%]
古老柑橘品种的单倍型解析基因组装为揭示易剥皮橙的驯化历史和果实性状形成提供了见解
Minqiang Yin,Xiaochan Song,Chao He et al.
Minqiang Yin et al.
Background: Loose-skin mandarins (LSMs) are among the oldest domesticated horticultural crops, yet their domestication history and the genetic basis underlying the formation of key selected traits remain unclear. ...
Multi-task benchmarking of spatially resolved gene expression simulation models [0.03%]
空间解析基因表达模拟模型的多任务基准测试
Xiaoqi Liang,Marni Torkel,Yue Cao et al.
Xiaoqi Liang et al.
Background: Computational methods for spatially resolved transcriptomics (SRT) are often developed and assessed using simulated data. The effectiveness of these evaluations relies on the ability of simulation methods to a...
A special short-wing petal faba genome and genetic dissection of floral and yield-related traits accelerate breeding and improvement of faba bean [0.03%]
特殊短翼花瓣的扁豆基因组及其对花部和产量相关性状的遗传解析加速了扁豆的育种与改良
Rong Liu,Chaoqin Hu,Dan Gao et al.
Rong Liu et al.
Background: A comprehensive study of the genome and genetics of superior germplasms is fundamental for crop improvement. As a widely adapted protein crop with high yield potential, the improvement in breeding and developm...
Systematic interrogation of functional genes underlying cholesterol and lipid homeostasis [0.03%]
系统分析控制胆固醇和脂质稳态的功能基因
Haihuan Shan,Shuangshuang Fan,Quanrun Li et al.
Haihuan Shan et al.
Background: Dyslipidemia or hypercholesterolemia are among the main risk factors for cardiovascular diseases. Unraveling the molecular basis of lipid or cholesterol homeostasis would help to identify novel drug targets an...
A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients [0.03%]
COVID-19患者肝脏的单细胞核及空间转录组图谱揭示了器官在拓扑结构、功能和再生上的紊乱
Yered Pita-Juarez,Dimitra Karagkouni,Nikolaos Kalavros et al.
Yered Pita-Juarez et al.
Background: The molecular underpinnings of organ dysfunction in severe COVID-19 and its potential long-term sequelae are under intense investigation. To shed light on these in the context of liver function, we perform sin...
Integrative phenomics, metabolomics and genomics analysis provides new insights for deciphering the genetic basis of metabolism in polished rice [0.03%]
整合表型组学、代谢组学和基因组学分析为阐明抛光稻米新陈代谢的遗传基础提供了新的见解
Hui Feng,Yufei Li,Guoxin Dai et al.
Hui Feng et al.
Background: Metabolomics is one of the most widely used omics tools for deciphering the functional networks of the metabolites for crop improvement. However, it is technically demanding and costly. ...