Author Correction: Combining different CRISPR nucleases for simultaneous knock-in and base editing prevents translocations in multiplex-edited CAR T cells [0.03%]
作者更正：结合不同的CRISPR核酸酶进行同时敲入和基础编辑可防止多重编辑CAR T细胞中的易位
Viktor Glaser,Christian Flugel,Jonas Kath et al.
Viktor Glaser et al.
Published Erratum
Genome biology. 2025 Mar 26;26(1):71. DOI:10.1186/s13059-025-03548-z 2025
Regulatory and disruptive variants in the CLCN2 gene are associated with modified skin color pattern phenotypes in the corn snake [0.03%]
CLCN2基因中的调控变异和颠覆性变异与玉米蛇皮肤颜色图案表型的改变相关
Sophie A Montandon,Pierre Beaudier,Asier Ullate-Agote et al.
Sophie A Montandon et al.
Background: Snakes exhibit a broad variety of adaptive colors and color patterns, generated by the spatial arrangement of chromatophores, but little is known of the mechanisms responsible for these spectacular traits. Her...
LocusMasterTE: integrating long-read RNA sequencing improves locus-specific quantification of transposable element expression [0.03%]
LocusMasterTE：整合长读RNA序列以提高转座子表达的定位特异性定量准确性
Sojung Lee,Jayne A Barbour,Yee Man Tam et al.
Sojung Lee et al.
Transposable elements (TEs) can influence human diseases by disrupting genome integrity, yet their quantification has been challenging due to the repetitive nature of these sequences across the genome. We develop LocusMasterTE, a method tha...
Survey of gene, lncRNA and transposon transcription patterns in four mouse organs highlights shared and organ-specific sex-biased regulation [0.03%]
对小鼠四种器官中的基因、长非编码 RNA 和转座子的转录模式进行调研，强调共用和器官特异性性别偏向性调控
Qinwei Kim-Wee Zhuang,Klara Bauermeister,Jose Hector Galvez et al.
Qinwei Kim-Wee Zhuang et al.
Background: Sex-biased gene regulation is the basis of sexual dimorphism in phenotypes and has been studied across different cell types and different developmental stages. However, sex-biased expression of transposable el...
Clonal expansion dictates the efficacy of mitochondrial lineage tracing in single cells [0.03%]
克隆扩增决定线粒体谱系追踪在单细胞中的效果
Xin Wang,Kun Wang,Weixing Zhang et al.
Xin Wang et al.
Background: Mitochondrial DNA (mtDNA) variants hold promise as endogenous barcodes for tracking human cell lineages, but their efficacy as reliable lineage markers are hindered by the complex dynamics of mtDNA in somatic ...
Functional genomic profiling of O-GlcNAc reveals its context-specific interplay with RNA polymerase II [0.03%]
O-糖胺聚糖的功能基因组分析显示其与RNA聚合酶II的特异性相互作用
Sofia Rucli,Nicolas Descostes,Yulia Ermakova et al.
Sofia Rucli et al.
Background: How reversible glycosylation of DNA-bound proteins acts on transcription remains scarcely understood. O-linked β-N-acetylglucosamine (O-GlcNAc) is the only known form of glycosylation modifying nuclear protei...
ASPM mediates nuclear entrapment of FOXM1 via liquid-liquid phase separation to promote progression of hepatocarcinoma [0.03%]
ASPM通过液-液相分离介导FOXM1的核滞留以促进肝癌进程
Xunliang Jiang,Jun Liu,Ke Wang et al.
Xunliang Jiang et al.
Background: Fork-head box protein M1 (FOXM1) plays critical roles in development and progression of multiple cancers, including hepatocellular carcinoma (HCC). However, the exact regulatory hierarchy of FOXM1 remains uncl...
aurora: a machine learning gwas tool for analyzing microbial habitat adaptation [0.03%]
Aurora：用于分析微生物栖息地适应性的机器学习GWAS工具
Dalimil Bujdoš,Jens Walter,Paul W O&#x;Toole
Dalimil Bujdoš
A primary goal of microbial genome-wide association studies is identifying genomic variants associated with a particular habitat. Existing tools fail to identify known causal variants if the analyzed trait shaped the phylogeny. Furthermore,...
Dissecting the genetic architecture of key agronomic traits in lettuce using a MAGIC population [0.03%]
利用MAGIC群体解析生菜关键农艺性状的遗传结构
Hongyun Chen,Jiongjiong Chen,Ruifang Zhai et al.
Hongyun Chen et al.
Background: Lettuce is a globally important leafy vegetable that exhibits diverse horticultural types and strong population structure, which complicates genetic analyses. To address this challenge, we develop the first mu...
scVAEDer: integrating deep diffusion models and variational autoencoders for single-cell transcriptomics analysis [0.03%]
scVAEDer：结合深度扩散模型和变分自编码器进行单细胞转录组学分析
Mehrshad Sadria,Anita Layton
Mehrshad Sadria
Discovering a lower-dimensional embedding of single-cell data can improve downstream analysis. The embedding should encapsulate both the high-level features and low-level variations. While existing generative models attempt to learn such lo...