SINTER3D: continuous 3D reconstruction of spatial transcriptomics via implicit neural representations [0.03%]
基于隐式神经表示的连续三维空间转录组重建（SINTER3D）
Tianjiao Zhang,Shenghe Li,Hongfei Zhang et al.
Tianjiao Zhang et al.
Spatial transcriptomics enables gene-expression profiling while preserving spatial context, but three-dimensional reconstruction from discrete tissue sections remains limited by large inter-section gaps and gene-wise independent interpolati...
Taxonomy-aware, disorder-matched benchmarking of phase-separating protein predictors [0.03%]
基于_taxonomy_的干扰素紊乱匹配基准相分离蛋白质预测器
Shuang Hou,Hexin Shen,Yong Zhang
Shuang Hou
Background: Biomolecular condensates formed via liquid-liquid phase separation (LLPS) play vital roles in cellular organization and function. Computational prediction of phase-separating proteins (PSPs) is increasingly us...
A cytoplasmic index for quantifying immune-related A-to-I RNA editing [0.03%]
一种定量免疫相关的A到I RNA编辑的细胞质指数
Roni Cohen-Fultheim,Itamar Twersky,Haim Krupkin et al.
Roni Cohen-Fultheim et al.
Background: Distinguishing self from non-self is a major challenge for the immune system. Endogenous cytoplasmic double-stranded RNA (dsRNA) can mimic viral RNA and activate immune sensors like MDA5. ADAR1-mediated adenos...
MGA: a tool for haplotype-mixed assembly of long and accurate reads [0.03%]
MGA：一种用于长而准确的混合基因型读段装配工具
Zhenmiao Zhang,Marcus W Fedarko,Anton Bankevich et al.
Zhenmiao Zhang et al.
Recent large-scale genome sequencing projects have generated near-complete diploid assemblies that reconstruct both haplomes. Producing such assemblies remains formidable, typically requiring large teams, extensive manual curation, and inte...
Spatial and single-cell transcriptomics uncover brassinosteroid-mediated coordination of sepal elongation in Arabidopsis [0.03%]
空间和单细胞转录组揭示 brassinosteroid介导的拟南芥萼片伸长协调作用
Byron Rusnak,Lilijana Sarabia Oliver,Kyle Procopio et al.
Byron Rusnak et al.
Background: Arabidopsis sepals must grow in a coordinated and robust manner to achieve consistent size and shape, ensuring proper closure and protecting the developing flower bud. To understand how this robust coordinatio...
Transposable element dynamics drive rapid evolution of centromere architecture in the Avena genus [0.03%]
转座元件动力学驱动亚麻属中着丝粒结构的快速进化
Carlotta Marie Wehrkamp,Matthias Heuberger,Thomas Wicker
Carlotta Marie Wehrkamp
Background: Recent advances in assemblies of nearly gap-free, high-quality genomes have enabled detailed analysis of centromeres in large and highly repetitive crop genomes. Here, we analyze the centromeres of hexaploid o...
Epistasis plays a limited role in driving entrenchment during neutral protein evolution [0.03%]
上位性在中性蛋白质进化过程中固化作用的发挥中起到的作用有限
Lisa Schmelkin,Sarah Chung,Allan Haldane et al.
Lisa Schmelkin et al.
Background: Substitutional entrenchment arising from epistatic interactions renders previously acceptable amino-acid states unfavorable over evolutionary time and has often been attributed to novel adaptive processes. How...
Directed evolution of compact RNA-guided nucleases for enhanced activity in mammalian cells [0.03%]
活性增强的用于哺乳动物细胞的紧凑型RNA引导内切酶的定向进化
Fedor Gorbenko,Irene Sala,Young-Yoon Lee et al.
Fedor Gorbenko et al.
Background: RNA-guided nucleases enable DNA editing and offer promise for treating genetic diseases, particularly when used for precise sequence replacement. However, many of the most effective enzymes, such as Streptococ...
4-hydroxy-5-methyl-3(2H)-furanone mediates widespread interkingdom communications between fungi and prokaryotes [0.03%]
4-羟基-5-甲基-3(2H)-呋喃酮介导真菌和原核生物之间的广泛界间通讯
Xinyu Qian,Yan-Bo Zhao,Heng Zhang et al.
Xinyu Qian et al.
Background: Fungal-prokaryotic interactions are widespread in natural and host-associated habitats. These interactions are believed to play crucial roles in ecosystem functioning and health. However, the cell-cell interac...
Telomere-to-telomere genome of Stylosanthes guianensis uncovers symbiotic adaptation to phosphorus-deficient soils [0.03%]
完全组装的柱花草基因组解析磷缺乏土壤适应性分子机制
Pandao Liu,Chun Liu,Wenhui Pu et al.
Pandao Liu et al.
Background: Stylosanthes guianensis, a representative tropical legume, exhibits remarkable adaptation to low-phosphorus acidic soils. As a symbiotic species, it forms root nodule associations with rhizobia to fix atmosphe...