IFDlong: a model-based isoform and fusion detector for accurate annotation and quantification of long-read RNA-seq data [0.03%]
Wenjia Wang,Jia-Jun Liu,Yuzhen Li et al.
Wenjia Wang et al.
Long-read transcriptome sequencing (long-RNA-seq) revolutionizes transcriptome research by enabling full-length transcript analysis for comprehensive exploration of isoform diversity. We developed IFDlong, a probabilistic framework and soft...
Setareh Tasdighian,Cecilia Sensalari,Steven Maere
Setareh Tasdighian
Background: Traces of ancient whole-genome multiplications (WGMs) have been observed all over the plant kingdom and have been associated with various evolutionary processes, such as increased evolvability, speciation, ada...
Centromere evolution in annual and perennial soybeans and its implication for hybridization in cultivated species [0.03%]
Jiamin Hou,Yanni Wei,Hui Liu et al.
Jiamin Hou et al.
Background: Centromeres are comprised of repeats and centromeric specific histone H3 (CENH3), and they play essential roles in maintaining genome stability and defining chromosome karyotypes. Previous studies in monocotyl...
The genomic history of Streptococcus mutans from the Mesolithic until modern times [0.03%]
从旧石器时代晚期到现代的变异链球菌基因组历史研究
Vincent F D F Thygesen,Motahare Feizabadi Farahani,Sofie Holtsmark Nielsen et al.
Vincent F D F Thygesen et al.
Background: Streptococcus mutans is a member of the human oral microbiota and is considered one of the most important cariogenic organisms. Previous studies have suggested an expansion of S. mutans populations about 10,00...
Asier Larrea-Sebal,Chengxin Dai,Alejandro J Brenes et al.
Asier Larrea-Sebal et al.
The circulating blood proteome comprises soluble and cellular components that reflect physiological and pathological states across tissues. Advances in mass spectrometry and affinity-based proteomics have improved sensitivity and throughput...
Recurrent sex chromosome turnover mediated by distinct ARR17 and PISTILLATA duplications in willows [0.03%]
柳树中由ARR17和PISTILLATA不同复制介导的性染色体周转反复发生
Yuàn Wang,Zhi-Qing Xue,Ren-Gang Zhang et al.
Yuàn Wang et al.
Background: Sex chromosome turnovers evolve via translocation or duplication of established sex-determining genes, or their replacement by newly evolved ones. Few cases of replacements by new factors have been documented ...
Systematic evaluation of single-cell multimodal data integration enhances cell type resolution and discovery of clinically relevant states in complex tissues [0.03%]
系统评估单细胞多模态数据整合可提高复杂组织中细胞类型的分辨率和临床相关状态的发现能力
Mario Acera-Mateos,Xian Adiconis,Jessica-Kanglin Li et al.
Mario Acera-Mateos et al.
Background: The integration of multimodal single-cell data enables comprehensive organ reference atlases, yet its impact remains largely unexplored, particularly in complex tissues. Using the kidney as an emblematic examp...
Proteomics and tracer metabolomics link GAPDH ISGylation to glycolytic control [0.03%]
蛋白质组学和追踪代谢组学将GAPDH ISG化与糖酵解控制相联系
Denzel Eggermont,Lissa Eggermont,Nagihan Aslantaş et al.
Denzel Eggermont et al.
Background: Ubiquitin-like protein ISG15 (interferon-stimulated gene 15) is implicated in the regulation of central carbon metabolism, but conflicting findings across experimental systems limit mechanistic insight. Here, ...
Advances in single-cell and spatial omics for studying symbiotic nitrogen fixation: comparative cellular and evolutionary perspectives [0.03%]
单细胞和空间组学在研究共生固氮作用方面的进展：比较细胞和进化视角
Yan Shi,Huiru Liu,Weicai Yang et al.
Yan Shi et al.
Single-cell and spatial transcriptomics have revolutionized studies of symbiotic nitrogen fixation by resolving cellular heterogeneity, spatial gene-expression, and regulatory dynamics within root nodules. Recent investigations in model leg...
Comparative centromere genomics reveals evolutionary divergence in Solanaceae genomes [0.03%]
比较中心体基因组学揭示了Solanceae基因组的进化分歧
Penglong Wan,Ming Hu,Hongyu Jin et al.
Penglong Wan et al.
Background: Centromeres are chromosomal loci epigenetically specified by the histone variant CENH3, where kinetochores assemble to ensure accurate chromosome segregation during cell division. Their repetitive and rapidly ...