Artemisinin alleviates Parkinson's disease by targeting Adcy5-Gch1 axis to trigger a cascade generation of BH4 and dopamine in rats [0.03%]
青蒿素通过作用于Adcy5-Gch1轴触发BH4和多巴胺级联生成缓解帕金森病研究
Xin-Xing Yang,Guo-Qing Wang,Qian Wen et al.
Xin-Xing Yang et al.
Background: Parkinson's disease is a highly prevalent neurodegenerative disorder. Hyposecretion of dopamine (DA) is the end result in the pathology of Parkinson's disease. Unfortunately, safe and efficient therapeutic dru...
RoAM: computational reconstruction of ancient methylomes and identification of differentially methylated regions [0.03%]
古甲基组的计算重建及差异甲基化区域的识别
Yoav Mathov,Naomi Rosen,Chen Leibson et al.
Yoav Mathov et al.
We present a new and considerably improved version of RoAM (Reconstruction of Ancient Methylation), a flexible tool for reconstructing ancient methylomes and identifying differentially methylated regions (DMRs) between populations. Through ...
Comparative benchmarking of single-cell clustering algorithms for transcriptomic and proteomic data [0.03%]
转录组和蛋白质基因组数据的单细胞聚类算法的比较基准测试
Yu-Hang Yin,Fang Wang,Wei Li et al.
Yu-Hang Yin et al.
Background: Differences in data distribution, feature dimensions, and quality between different single-cell modalities pose challenges for clustering. Although clustering algorithms have been developed for single-cell tra...
Comparative Study
Genome biology. 2025 Sep 3;26(1):265. DOI:10.1186/s13059-025-03719-y 2025
Ancient genomes provide evidence of demographic shift to Slavic-associated groups in Moravia [0.03%]
古基因组为捷克摩拉维亚运来的斯拉夫相关人群提供证据
Ilektra Schulz,Denisa Zlámalová,Carlos S Reyna-Blanco et al.
Ilektra Schulz et al.
Background: The Slavs are a major ethnolinguistic group of Europe, yet the process that led to their formation remains disputed. As of the sixth century CE, people supposedly belonging to the Slavs populated the space bet...
Imbalanced chromatin distribution in cellular senescence specifies paraspeckle dynamics [0.03%]
染色质分布不平衡控制衰老细胞中寄生 speck 动态变化机制研究
Joonwoo Lee,Jinmi Choi,Jeongeun Park et al.
Joonwoo Lee et al.
Cellular senescence is accompanied by extensive genomic reorganization, such as senescence-associated heterochromatin foci and expanded interchromatin compartments, to ultimately affect gene expression. Here, we demonstrate that chromatin s...
CLDN10-driven lineage decision in an amnion and primordial germ cell progenitor at the amnion-epiblast boundary in primates [0.03%]
灵长类胚胎原条和羊膜交界区的羊膜及生殖细胞祖细胞分化路径中的 Claudin 10 线粒决定作用
Nikola Sekulovski,Amber E Carleton,Anusha Rengarajan et al.
Nikola Sekulovski et al.
Background: A growing body of evidence from primate embryos as well as in vitro systems supports the notion that amnion and primordial germ cell (PGC) lineage progressing cells share a common precursor. ...
U-FISH: a fluorescent spot detector for imaging-based spatial-omics analysis and AI-assisted FISH diagnosis [0.03%]
U-FISH：一种用于基于影像的空间组学分析和AI辅助的FISH诊断的荧光点检测器
Weize Xu,Huaiyuan Cai,Qian Zhang et al.
Weize Xu et al.
Imaging-based spatial-omics advances biomedical discoveries with subcellular resolution and high sensitivity, but accurately identifying signal spots from diverse images remains challenging. We develop U-FISH, a deep learning method that en...
Mammalian conservation of endogenous G-quadruplex reveals their associations with complex traits [0.03%]
内源性G-四链体的哺乳动物保守性及其与复杂性状之间的关联
Ze-Hao Zhang,Zi-Yan Wang,Cong-Hui Li et al.
Ze-Hao Zhang et al.
Background: DNA G-quadruplexes (G4s) are four-stranded DNA structures. Endogenous G-quadruplexes (eG4s) have been identified as pivotal regulatory elements for gene expression in the human genome. The measurement of evolu...
Chemoreceptor family in plant-associated bacteria responds preferentially to the plant signal molecule glycerol 3-phosphate [0.03%]
植物相关细菌中的化学感受器家族偏好性地响应植物信号分子甘油-3-磷酸
Félix Velando,Jiawei Xing,Roberta Genova et al.
Félix Velando et al.
Background: Chemotaxis to plant compounds is frequently the initial step for the colonization of plants by bacteria. Plant pathogens and plant-associated bacteria contain approximately twice as many chemoreceptors as the ...
Integrated phenomic and genomic analyses unveil modes of altered phenotypic plasticity during wheat improvement [0.03%]
集成表型组和基因组分析揭示了小麦改良过程中表型可塑性变化的模式
Linqian Han,Xiaoming Wang,Ryan Benke et al.
Linqian Han et al.
Background: Wheat has a critical role in global food security. During the improvement of wheat from landraces to cultivars, a suite of traits has been modified for higher yields. However, changing patterns of wheat in res...