Patterns of extreme outlier gene expression suggest an edge of chaos effect in transcriptomic networks [0.03%]
极端异常基因表达模式表明转录组网络存在混沌边缘效应
Chen Xie,Sven Künzel,Wenyu Zhang et al.
Chen Xie et al.
Background: Most RNA-seq datasets harbor genes with extreme expression levels in some samples. Such extreme outliers are usually treated as technical errors and are removed from the data before further statistical analysi...
Distinct evolutionary trajectories of subgenomic centromeres in polyploid wheat [0.03%]
多倍体小麦次基因组着丝粒的进化轨迹区分化
Yuhong Huang,Yang Liu,Chang Liu et al.
Yuhong Huang et al.
Background: Centromeres are crucial for precise chromosome segregation and maintaining genome stability during cell division. However, their evolutionary dynamics, particularly in polyploid organisms with complex genomic ...
Bacillus drives functional states in synthetic plant root bacterial communities [0.03%]
芽孢杆菌驱动合成植物根系细菌群落的功能状态
Gijs Selten,Ronnie de Jonge
Gijs Selten
Background: Plant roots release root exudates to attract microbes that form root communities, which in turn promote plant health and growth. Root community assembly arises from millions of interactions between microbes an...
Meta-Analysis
Genome biology. 2025 Sep 9;26(1):270. DOI:10.1186/s13059-025-03739-8 2025
Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals [0.03%]
基于246,000人的全基因组序列分析低密度脂蛋白胆固醇变异的影响
Margaret Sunitha Selvaraj,Xihao Li,Zilin Li et al.
Margaret Sunitha Selvaraj et al.
Background: Rare genetic variation provided by whole genome sequence datasets has been relatively less explored for its contributions to human traits. Meta-analysis of sequencing data offers advantages by integrating larg...
Meta-Analysis
Genome biology. 2025 Sep 9;26(1):273. DOI:10.1186/s13059-025-03698-0 2025
DNA G-quadruplex profiling in skeletal muscle stem cells reveals functional and mechanistic insights [0.03%]
骨骼肌干细胞中的DNA G-四链体特征研究揭示了功能和机制方面的见解
Xiaona Chen,Feng Yang,Suyang Zhang et al.
Xiaona Chen et al.
Background: DNA G-quadruplexes (G4s) are non-canonical secondary structures formed in guanine-rich DNA sequences and play important roles in modulating biological processes through a variety of gene regulatory mechanisms....
Evolutionary diversification of ancestral genes across vertebrates and insects [0.03%]
脊椎动物和昆虫祖先基因的进化分化
Federica Mantica,Manuel Irimia
Federica Mantica
Background: Vertebrates and insects diverged approximately 700 million years ago, and yet they retain a large core of conserved genes from their last common ancestor. These ancient genes present strong evolutionary constr...
Artemisinin alleviates Parkinson's disease by targeting Adcy5-Gch1 axis to trigger a cascade generation of BH4 and dopamine in rats [0.03%]
青蒿素通过作用于Adcy5-Gch1轴触发BH4和多巴胺级联生成缓解帕金森病研究
Xin-Xing Yang,Guo-Qing Wang,Qian Wen et al.
Xin-Xing Yang et al.
Background: Parkinson's disease is a highly prevalent neurodegenerative disorder. Hyposecretion of dopamine (DA) is the end result in the pathology of Parkinson's disease. Unfortunately, safe and efficient therapeutic dru...
RoAM: computational reconstruction of ancient methylomes and identification of differentially methylated regions [0.03%]
古甲基组的计算重建及差异甲基化区域的识别
Yoav Mathov,Naomi Rosen,Chen Leibson et al.
Yoav Mathov et al.
We present a new and considerably improved version of RoAM (Reconstruction of Ancient Methylation), a flexible tool for reconstructing ancient methylomes and identifying differentially methylated regions (DMRs) between populations. Through ...
Comparative benchmarking of single-cell clustering algorithms for transcriptomic and proteomic data [0.03%]
转录组和蛋白质基因组数据的单细胞聚类算法的比较基准测试
Yu-Hang Yin,Fang Wang,Wei Li et al.
Yu-Hang Yin et al.
Background: Differences in data distribution, feature dimensions, and quality between different single-cell modalities pose challenges for clustering. Although clustering algorithms have been developed for single-cell tra...
Comparative Study
Genome biology. 2025 Sep 3;26(1):265. DOI:10.1186/s13059-025-03719-y 2025
Ancient genomes provide evidence of demographic shift to Slavic-associated groups in Moravia [0.03%]
古基因组为捷克摩拉维亚运来的斯拉夫相关人群提供证据
Ilektra Schulz,Denisa Zlámalová,Carlos S Reyna-Blanco et al.
Ilektra Schulz et al.
Background: The Slavs are a major ethnolinguistic group of Europe, yet the process that led to their formation remains disputed. As of the sixth century CE, people supposedly belonging to the Slavs populated the space bet...