Holotype genome of the lesula provides insights into demography and evolution of a threatened primate lineage [0.03%]
莱苏拉模式标本基因组揭示了一个受威胁灵长类谱系的人口动态及进化情况
Axel Jensen,Emma R Horton,Mardoché B Koko et al.
Axel Jensen et al.
Background: The development of genome sequencing techniques has revolutionized evolutionary biology, facilitating the study of adaptation and speciation at the genome level. Genomic data has also become a cornerstone in c...
A scalable equivariant graph network framework for precise protein function prediction [0.03%]
一种用于精确蛋白质功能预测的可扩展等变图网络框架
Zixu Ran,Xudong Guo,Tong Pan et al.
Zixu Ran et al.
Background: Protein function research helps in understanding the complex biological processes that occur within cells. However, the intricate nature of protein structures and functions, along with the rapid growth of prot...
HAlign-G: rapid and low-memory multiple-genome aligner for large-scale closely related genomes [0.03%]
HAlign-G：一种快速且低内存的大规模密切相关基因组对齐工具
Pinglu Zhang,Tong Zhou,Yanming Wei et al.
Pinglu Zhang et al.
HAlign-G is a fast and memory-efficient tool for large-scale multiple genome alignment. Using BWT-FM-LIS with an optimized K-band algorithm and star alignment strategy, it supports intra-species (HAlign-G1) and cross-species (HAlign-G2) ali...
Mitochondrial diversity of Bwindi Impenetrable National Park Mountain Gorillas [0.03%]
布恩迪姆森林国家公园山地大猩猩的线粒体多样性研究
Matthew A Knox,Valter Almeida,Gladys Kalema-Zikusoka et al.
Matthew A Knox et al.
Background: Mitochondrial DNA is a key marker for assessing genetic diversity, critical for the conservation of endangered species. This study investigates the mitochondrial diversity of the Bwindi Impenetrable National P...
Loss of IDH1 and IDH2 mutations during the evolution of metastatic chondrosarcoma [0.03%]
IDH1和IDH2在软骨肉瘤演变为转移性肿瘤过程中发生失活
William Cross,Iben Lyskjær,Christopher Davies et al.
William Cross et al.
Driver mutations in IDH1 and IDH2 are initiating events in the evolution of chondrosarcoma and several other cancer types. Here, we present evidence that mutant IDH1 is recurrently lost in metastatic central chondrosarcoma. This may reflect...
Ming-Ching C Wen,Joshua D Welch
Ming-Ching C Wen
Transposable elements (TEs) are often epigenetically repressed in eukaryotic cells, but still affect the molecular state of the cell in certain contexts. A flurry of recent studies have elucidated new effects of TE sequences in eukaryotic c...
scKGBERT: a knowledge-enhanced foundation model for single-cell transcriptomics [0.03%]
基于知识增强的单细胞转录组基础模型 scKGBERT
Yang Li,Guanyu Qiao,Hongli Du et al.
Yang Li et al.
Single-cell transcriptomics enables precise characterization of cellular heterogeneity, but current pre-trained models relying solely on expression data fail to capture gene associations. We present scKGBERT, a knowledge-enhanced foundation...
A reinforcement learning-based approach for dynamic privacy protection in genomic data sharing beacons [0.03%]
基于强化学习的基因组数据分享灯塔中的动态隐私保护方法
Masoud Poorghaffar Aghdam,Sobhan Shukueian Tabrizi,Kerem Ayöz et al.
Masoud Poorghaffar Aghdam et al.
The rise of genomic sequencing raises privacy concerns due to the identifiable nature of genomic data. The GA4GH Beacon Project enables privacy-preserving data sharing but is vulnerable to membership inference attacks that reveal individual...
HGMT: a database of human gut microbiota for tumors and immunotherapy response [0.03%]
HGMT数据库：肿瘤和免疫治疗反应的人体肠道微生物组
Jinxin Liu,Mingyu Wang,Chentao Xu et al.
Jinxin Liu et al.
HGMT is a database designed to analyze, explore, and visualize gut microbiomes from diverse tumor types. We process metagenomic datasets from 18,630 stool samples across 37 tumor types, including 2,207 samples from immunotherapy-treated pat...
Mycobacterium tuberculosis uses intrinsically disordered, fast evolving proteins to interact with conserved host factors [0.03%]
结核分枝杆菌利用内在无序且快速进化的蛋白质与宿主固有因子相互作用
Uberto Pozzoli,Diego Forni,Federica Arrigoni et al.
Uberto Pozzoli et al.
Background: Intrinsically disordered protein regions (IDRs) are implicated in diverse cellular processes in eukaryotes and, in these organisms, they cover up to 40% of the proteome. Surprisingly little is known about IDRs...