AP1 is a pioneer transcription factor that programmes cell fate through MADS-domain protein tetramerisation [0.03%]
AP1是一个转录因子，通过MADS结构域蛋白四聚化来编程细胞命运
Xiaocai Xu,Manuel Neumann,Frederic Carew et al.
Xiaocai Xu et al.
Identifying cell-type-specific spatially variable genes with ctSVG [0.03%]
利用ctSVG识别具有空间异质性的细胞类型特异性基因
Haotian Zhuang,Xinyi Shang,Wenpin Hou et al.
Haotian Zhuang et al.
Spatially variable genes (SVGs) reveal the molecular and functional heterogeneity of cells across different spatial regions of a tissue. Sample-wide SVGs identified by existing methods largely overlap with cell-type marker genes derived fro...
Methylome-wide association studies and epigenetic biomarker development for 133 mass spectrometry-assessed circulating proteins in 14,671 Generation Scotland participants [0.03%]
一万四千多名Generation Scotland研究对象的133种质谱检测循环蛋白的全甲基化组关联分析及表观遗传生物标志物开发
Josephine A Robertson,Jakub Bajzik,Spyros Vernardis et al.
Josephine A Robertson et al.
Background: DNA methylation (DNAm) can regulate gene expression, and its genome-wide patterns (epigenetic scores or EpiScores) can act as biomarkers for complex traits. The relative stability of methylation profiles may e...
Unraveling genome- and immunome-wide genetic diversity in modern and historical Jaguars [0.03%]
现代和历史美洲豹的基因组和免疫组遗传多样性解析
René Meißner,Sven Winter,Jean Pierre Elbers et al.
René Meißner et al.
Background: The jaguar (Panthera onca) is a keystone species within diverse ecosystems ranging from dense rainforests to open grasslands across Central and South America. However, its populations are declining rapidly due...
3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility [0.03%]
基于57种人类细胞类型中的染色体构象的变异基因图谱揭示了自身免疫疾病易感性的细胞和遗传结构
Khanh B Trang,Prabhat Sharma,Laura Cook et al.
Khanh B Trang et al.
Background: Insight into the genetic basis for many common autoimmune disorders has been uncovered by genome-wide association studies (GWAS), but this alone does not reveal causal variants, effector genes, or the cell typ...
Large DNA and protein language models enhance discovery of deleterious mutations in maize [0.03%]
大型DNA和蛋白质语言模型可增强玉米有害突变的发现
Yiru Wang,Cheng He,Qiqi Wang et al.
Yiru Wang et al.
Background: The maize inbred line Chang7-2 and derived lines are important male donors for hybrid production, contributing significantly to the development of high-yield and stress-tolerant hybrids. Additionally, Chang7-2...
Bamdam: a post-mapping authentication toolkit for ancient metagenomics [0.03%]
Bamdam：一种用于古代元基因组学的映射后认证工具包
Bianca De Sanctis,Cade Mirchandani,Haoran Dong et al.
Bianca De Sanctis et al.
Ancient metagenomic studies using capture or shotgun sequencing often perform pairwise alignment of individual reads against large reference databases followed by lowest common ancestor assignment for taxonomic identification. Here, we pres...
CRISPR-Cas9-induced double-strand breaks disrupt maintenance of epigenetic information [0.03%]
CRISPR-Cas9诱导的双链断裂打断表观遗传信息的维持
Mengge Wang,Yingzi Zhang,Chongwei Bi et al.
Mengge Wang et al.
Background: CRISPR-Cas9 genome editing enables precise genetic modifications by introducing targeted DNA double-strand breaks (DSBs). While Cas9-induced DSBs are known to cause unintended on-target mutations, their impact...
SwitchTFI: identifying transcription factors driving cell differentiation [0.03%]
SwitchTFI：识别驱动细胞分化的转录因子
Paul Martini,Anne Hartebrodt,Gustavo P de Almeida et al.
Paul Martini et al.
Many methods exist that infer cell differentiation trajectories from single-cell RNA sequencing data, but only few determine which mechanisms drive the inferred differentiation dynamics. To close this gap, we developed the algorithm and Pyt...
Evaluation of false positive and false negative errors in targeted next generation sequencing [0.03%]
目标下一代测序假阳性和假阴性错误的评估
Youngbeen Moon,Young-Ho Kim,Jong-Kwang Kim et al.
Youngbeen Moon et al.
Background: Next-generation sequencing (NGS) has become an indispensable diagnostic tool across various diseases. However, sequencing and analysis errors remain major barriers to clinical implementation. In cancer diagnos...