New insights into the cold tolerance of upland switchgrass by integrating a haplotype-resolved genome and multi-omics analysis [0.03%]
通过整合单倍型解析基因组和多组学分析深入研究高梁的耐冷性
Bingchao Wu,Dan Luo,Yuesen Yue et al.
Bingchao Wu et al.
Background: Switchgrass (Panicum virgatum L.) is a bioenergy and forage crop. Upland switchgrass exhibits superior cold tolerance compared to the lowland ecotype, but the underlying molecular mechanisms remain unclear. ...
Deciphering the role of RNA in regulating CTCF's DNA binding affinity in leukemia cells [0.03%]
解密RNA在白血病细胞中对CTCFDNA结合亲和力调节的作用
Judith Hyle,Wenjie Qi,Mohamed Nadhir Djekidel et al.
Judith Hyle et al.
Background: CTCF, a highly studied transcription factor, is essential for chromatin interaction maintenance. Several independent studies report that CTCF interacts with RNAs in vitro and in cells. Yet continuous debates a...
Endometrial tumorigenesis involves epigenetic plasticity demarcating non-coding somatic mutations and 3D-genome alterations [0.03%]
子宫肿瘤发生涉及表观遗传塑性、非编码体细胞突变和三维基因组改变之间的分界线
Sebastian Gregoricchio,Aleksandar Kojic,Marlous Hoogstraat et al.
Sebastian Gregoricchio et al.
Background: The incidence and mortality of endometrial cancer (EC) is on the rise. Eighty-five percent of ECs depend on estrogen receptor alpha (ERα) for proliferation, but little is known about its transcriptional regul...
ChromActivity: integrative epigenomic and functional characterization assay based annotation of regulatory activity across diverse human cell types [0.03%]
ChromActivity：基于多种人类细胞类型调控活性的表观基因组和功能特征注释整合分析方法
Tevfik Umut Dincer,Jason Ernst
Tevfik Umut Dincer
We introduce ChromActivity, a computational framework for predicting and annotating regulatory activity across the genome through integration of multiple epigenomic maps and various functional characterization datasets. ChromActivity genera...
Parent-of-origin regulation by maternal auts2 shapes neurodevelopment and behavior in fish [0.03%]
鱼的母源AUTS2调节影响神经发育和行为的父系基因表达
Antoine Emile Clément,Constance Merdrignac,Sergi Roig Puiggros et al.
Antoine Emile Clément et al.
Background: Parental experience can influence progeny behavior through gamete-mediated non-genetic inheritance, that is, mechanisms that do not involve changes in inherited DNA sequence. However, underlying mechanisms rem...
Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zones [0.03%]
大多数人类DNA复制起始事件分散在整个基因组中，仅有少数在之前鉴定的启动区域中
Jamie T Carrington,Rosemary H C Wilson,Eduardo de La Vega et al.
Jamie T Carrington et al.
Background: The identification of sites of DNA replication initiation in mammalian cells has been challenging. Here, we present unbiased detection of replication initiation events in human cells using BrdU incorporation a...
Epigenome profiling reveals distinctive regulatory features and cis-regulatory elements in pepper [0.03%]
表观基因组分析揭示了辣椒独特的调控特征和顺式调控元件
Hongji Yang,Guorong Yu,Zhidong Lv et al.
Hongji Yang et al.
Background: Pepper (Capsicum annuum) is one of the earliest and most widely cultivated vegetable crops worldwide. While the large and complex genome of pepper severely hampered the understanding of its functional genome, ...
Predicting adenine base editing efficiencies in different cellular contexts by deep learning [0.03%]
深度学习预测腺嘌呤碱基编辑在不同细胞环境下的效率
Lucas Kissling,Amina Mollaysa,Sharan Janjuha et al.
Lucas Kissling et al.
Background: Adenine base editors (ABEs) enable the conversion of A•T to G•C base pairs. Since the sequence of the target locus influences base editing efficiency, efforts have been made to develop computational models t...
Peak analysis of cell-free RNA finds recurrently protected narrow regions with clinical potential [0.03%]
无细胞RNA的峰值分析发现了具有临床潜力的反复保护的狭窄区域
Pengfei Bao,Taiwei Wang,Xiaofan Liu et al.
Pengfei Bao et al.
Background: Cell-free RNAs (cfRNAs) can be detected in biofluids and have emerged as valuable disease biomarkers. Accurate identification of the fragmented cfRNA signals, especially those originating from pathological cel...
ZAR1 and ZAR2 orchestrate the dynamics of maternal mRNA polyadenylation during mouse oocyte development [0.03%]
ZAR1和ZAR2调控小鼠卵母细胞发育过程中母源mRNA多聚腺苷酸化的动态变化
Yu-Ke Wu,Ruibao Su,Zhi-Yan Jiang et al.
Yu-Ke Wu et al.
Background: During meiosis, the oocyte genome keeps dormant for a long time until zygotic genome activation. The dynamics and homeostasis of the maternal transcriptome are essential for maternal-to-zygotic transition. Zyg...