HUBMet: an integrative database and analytical platform for human blood metabolites and metabolite-protein associations [0.03%]
HUBMet代谢物和代谢物-蛋白质关联的整合型数据库和分析平台
Xingyue Wang,Xiangyu Qiao,Alberto Zenere et al.
Xingyue Wang et al.
Understanding human blood metabolites is essential for deciphering systemic physiology and disease mechanisms, yet remains challenging due to diverse origins and dynamic regulation. In this study, we develop HUBMet (https://hubmet.app.bio-i...
The differential subcellular localization of soybean transcripts, an additional regulatory mechanism of gene activity [0.03%]
大豆转录本的不同亚细胞定位及其作为基因活性的额外调节机制
Sutton Tennant,Erik J Amezquita,Yaohua Li et al.
Sutton Tennant et al.
Background: Our understanding of gene function is often driven by its expression and, a fortiori, based on its RNA abundance in a cell, a tissue, or an organ. This assumption often neglects the limited correlation between...
Sinian Xing,Kunling Chen,Haocheng Zhu et al.
Sinian Xing et al.
Published Erratum
Genome biology. 2025 Dec 24;26(1):435. DOI:10.1186/s13059-025-03894-y 2025
PepQueryMHC: rapid and comprehensive tumor antigen prioritization from immunopeptidomics data [0.03%]
PepQueryMHC：从免疫肽组学数据中快速而全面地优先确定肿瘤抗原
Seunghyuk Choi,Bing Zhang
Seunghyuk Choi
Determining tumor-specificity of MHC-bound peptides is crucial for cancer immunotherapy development, yet current methods struggle with class II peptides and non-reference sequences. We introduce PepQueryMHC, an ultra-fast tool that integrat...
Sorghum embryos undergoing B chromosome elimination express B-variants of mitotic-related genes [0.03%]
正在经历B染色体消除的高梁胚胎表达与有丝分裂相关的B染色体变异基因
Tereza Bojdová,Lucie Hloušková,Kateřina Holušová et al.
Tereza Bojdová et al.
Background: Selective DNA elimination occurs across diverse species and plays a crucial role in evolution and development. This process encompasses small deletions, complete removal of chromosomes, or even the elimination...
Comparative assessment of SNP genotyping assays for challenging forensic samples utilizing ancient DNA methods [0.03%]
利用古DNA方法对疑难法医样本的SNP分型体系进行比较评估
Adam Staadig,Maja Krzewińska,Maja Sidstedt et al.
Adam Staadig et al.
Background: The fields of ancient DNA research and forensic genetics share both methodological similarities and common challenges, particularly in the analysis of degraded DNA. Leveraging these overlaps, this study evalua...
Comparative Study
Genome biology. 2025 Dec 23;26(1):433. DOI:10.1186/s13059-025-03912-z 2025
Multi-omics dissection of the genetic regulation underlying fatty acid composition in cattle [0.03%]
奶牛脂肪酸组成的遗传调控的多组学解析
Tianliu Zhang,Qunhao Niu,Tianzhen Wang et al.
Tianliu Zhang et al.
Background: Fatty acid composition is a complex trait governed by a polygenic architecture. Although numerous genetic variants associated with fatty acids have been identified through genome-wide association studies (GWAS...
Genome-wide modeling of DNA replication in space and time confirms the emergence of replication specific patterns in vivo in eukaryotes [0.03%]
空间和时间全局建模表明真核生物中DNA复制的特异模式的确存在
Dario D&#x;Asaro,Jean-Michel Arbona,Vinciane Piveteau et al.
Dario D&#x;Asaro et al.
Background: Although significant progress has been made in our understanding of DNA replication and spatial chromosome organization in eukaryotes, how they interplay remains elusive. In particular, from the local structur...
Antisense transcription can induce expression memory via stable promoter repression [0.03%]
反义转录可通过稳定地抑制启动子来诱导表达记忆
Verena Mutzel,Till Schwämmle,Svearike Oeverdieck et al.
Verena Mutzel et al.
Background: The capacity of cells to retain a memory of previous signals enables acquisition of unique fates and adaptation to their environment. The underlying gene expression memory can arise from mutual repression of t...
Elise Amblard,Vadim Bertrand,Hugo Barbot et al.
Elise Amblard et al.
Background: Tumour heterogeneity significantly affects cancer progression and therapeutic response, yet quantifying it from bulk molecular data remains challenging. Deconvolution algorithms, which estimate cell type propo...