Determinants of de novo mutations in extended pedigrees of 43 dog breeds [0.03%]
来自43个犬品种的大家系中新生突变的发生率和决定因素
Shao-Jie Zhang,Jilong Ma,Meritxell Riera et al.
Shao-Jie Zhang et al.
Background: Understanding the determinants of de novo mutation is critical for elucidating evolutionary processes and genetic disease susceptibility. But the interplay between life history, genomic architecture, and recom...
Antagonistic effects of selection on alleles associated with seed size and seed dormancy in wheat [0.03%]
小麦籽粒大小和休眠位点受选择效应的影响
Feilong Guo,Changbin Yin,Tian Li et al.
Feilong Guo et al.
Background: Seed dormancy and size are two crucial traits influencing crop yield, and they have undergone strong selection during cereal domestication and improvement. However, the genetic basis underlying the antagonisti...
scKAN: interpretable single-cell analysis for cell-type-specific gene discovery and drug repurposing via Kolmogorov-Arnold networks [0.03%]
基于柯尔莫哥洛夫-阿恩斯德网络的可解释单细胞分析：用于细胞类型特异性基因发现和药物重定位
Haohuai He,Zhenchao Tang,Guanxing Chen et al.
Haohuai He et al.
Background: Analysis of single-cell RNA sequencing (scRNA-seq) data has revolutionized our understanding of cellular heterogeneity, yet current approaches face challenges in efficiency, interpretability, and connecting mo...
Hanwen Zhou,Yue Hu,Yulong Zheng et al.
Hanwen Zhou et al.
Background: RNA metabolism is tightly regulated by cis-elements and trans-acting factors. Most information guiding such regulation is encoded in RNA sequences. Deciphering the regulatory rules is critical for RNA biology ...
Fueling chromosomal gene diversification and artificial evolution with CRISPR [0.03%]
利用CRISPR促进染色体基因多样化和人工进化
Ruiying Zhu,Chuanhong Ren,Zehua Bao
Ruiying Zhu
Gene diversification is an effective approach to massively dissecting variant functions and evolving sequences when paired with an appropriate assay. In vitro mutagenesis and ectopic gene expression, however, fail to simulate the endogenous...
Long-read sequencing reveals the RNA isoform repertoire of neuropsychiatric risk genes in human brain [0.03%]
长读序技术揭示人脑中神经精神疾病易感基因的RNA异构体組合
Ricardo De Paoli-Iseppi,Shweta S Joshi,Josie Gleeson et al.
Ricardo De Paoli-Iseppi et al.
Background: Neuropsychiatric disorders are highly complex conditions and the risk of developing a disorder has been tied to hundreds of genomic variants that alter the expression and/or RNA isoforms made by risk genes. Ho...
Identification of novel H2A histone variants across diverse clades of algae [0.03%]
藻类多样分类单元中新型H2A组蛋白变体的鉴定
Ellyn Rousselot,Zofia Nehr,Jean-Marc Aury et al.
Ellyn Rousselot et al.
Background: Histones are among the most conserved proteins in eukaryotes. They not only ensure DNA compaction in the nucleus but also participate in epigenetic regulation of gene expression. These key epigenetic players a...
GeneRAIN: multifaceted representation of genes via deep learning of gene expression networks [0.03%]
通过深度学习基因表达网络的基因多功能表示法(GeneRAIN)
Zheng Su,Mingyan Fang,Andrei Smolnikov et al.
Zheng Su et al.
We develop GeneRAIN, a suite of Transformer-based models that learn gene expression relationships from 410 K human bulk RNA-seq samples. Featuring a novel Binning-By-Gene normalization technique, our models capture diverse biological inform...
Regulation of heterosis-associated gene expression complementation in maize hybrids [0.03%]
调控玉米杂种优势相关基因表达互补的机制研究
Marion Pitz,Jutta A Baldauf,Hans-Peter Piepho et al.
Marion Pitz et al.
Background: Classical genetic concepts to explain heterosis attribute the superiority of F1-hybrids over their homozygous parents to the complementation of unfavorable by beneficial alleles (dominance) or to heterozygote ...
KEGNI: knowledge graph enhanced framework for gene regulatory network inference [0.03%]
基于知识图谱的基因调控网络推理框架
Pengxiao Li,Lin Li,Jingminjie Nan et al.
Pengxiao Li et al.
Inference of cell type-specific gene regulatory networks (GRNs) is a fundamental step in investigating complex regulatory mechanisms. Here, we present KEGNI (Knowledge graph-Enhanced Gene regulatory Network Inference), a knowledge-guided fr...