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期刊名:Genome biology

缩写:GENOME BIOL

ISSN:1474-760X

e-ISSN:1474-760X

IF/分区:9.4/Q1

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共收录本刊相关文章索引6360
Clinical Trial Case Reports Meta-Analysis RCT Review Systematic Review
Classical Article Case Reports Clinical Study Clinical Trial Clinical Trial Protocol Comment Comparative Study Editorial Guideline Letter Meta-Analysis Multicenter Study Observational Study Randomized Controlled Trial Review Systematic Review
Antoine Passemiers,Stefania Tuveri,Tatjana Jatsenko et al. Antoine Passemiers et al.
Cell-free DNA (cfDNA) is a rich source of biomarkers for various pathophysiological conditions. Preanalytical variables, such as the library preparation protocol or sequencing platform, are major confounders of cfDNA analysis. We present DA...
Qian Liu,Yang Liu,Congyang Yi et al. Qian Liu et al.
Background: B chromosomes contribute to the genetic variation in numerous eukaryotes. Yet their genetic and epigenetic characteristics, as well as their effects on the host genome remain poorly understood. ...
Pol Vendrell-Mir,Basile Leduque,Leandro Quadrana Pol Vendrell-Mir
Background: Mobilization of transposable elements (TEs) can generate large effect mutations. However, due to the difficulty of detecting new TE insertions in genomes and the typically rare occurrence of transposition, the...
Chen-Yang Li,Yong-Jia Hong,Bo Li et al. Chen-Yang Li et al.
Background: Recent advances in single-cell multimodal omics sequencing have facilitated the simultaneous profiling of transcriptomes and surface proteomes within individual cells, offering insights into cellular functions...
Josep Biayna,Gabrijela Dumbović Josep Biayna
Eukaryotic cells are highly structured and composed of multiple membrane-bound and membraneless organelles. Subcellular RNA localization is a critical regulator of RNA function, influencing various biological processes. At any given moment,...
Xue Yang,Li Cheng,Ye Xin et al. Xue Yang et al.
Background: CTCF is considered as the most essential transcription factor regulating chromatin architecture and gene expression. However, genome-wide impact of CTCF on erythropoiesis has not been extensively investigated....
Nicolas Antonio da Silva,Onur Özer,Magdalena Haller-Caskie et al. Nicolas Antonio da Silva et al.
Background: The northern European Neolithic is characterized by two major demographic events: immigration of early farmers from Anatolia at 7500 years before present, and their admixture with local western hunter-gatherer...
Thomas Cantore,Paola Gasperini,Riccardo Bevilacqua et al. Thomas Cantore et al.
Gene context-essentiality assessment supports precision oncology opportunities. The variability of gene effects inference from loss-of-function screenings across models and technologies limits identifying robust hits. We propose a computati...
Ran Zhang,Mu Yang,Jacob Schreiber et al. Ran Zhang et al.
Cross-species comparison and prediction of gene expression profiles are important to understand regulatory changes during evolution and to transfer knowledge learned from model organisms to humans. Single-cell RNA-seq (scRNA-seq) profiles e...
Henri Schmidt,Minsi Zhang,Dimitar Chakarov et al. Henri Schmidt et al.
We present GuideScan2 for memory-efficient, parallelizable construction of high-specificity CRISPR guide RNA (gRNA) databases and user-friendly design and analysis of individual gRNAs and gRNA libraries for targeting coding and non-coding r...