Multi-task benchmarking of spatially resolved gene expression simulation models [0.03%]
空间解析基因表达模拟模型的多任务基准测试
Xiaoqi Liang,Marni Torkel,Yue Cao et al.
Xiaoqi Liang et al.
Background: Computational methods for spatially resolved transcriptomics (SRT) are often developed and assessed using simulated data. The effectiveness of these evaluations relies on the ability of simulation methods to a...
A special short-wing petal faba genome and genetic dissection of floral and yield-related traits accelerate breeding and improvement of faba bean [0.03%]
特殊短翼花瓣的扁豆基因组及其对花部和产量相关性状的遗传解析加速了扁豆的育种与改良
Rong Liu,Chaoqin Hu,Dan Gao et al.
Rong Liu et al.
Background: A comprehensive study of the genome and genetics of superior germplasms is fundamental for crop improvement. As a widely adapted protein crop with high yield potential, the improvement in breeding and developm...
Systematic interrogation of functional genes underlying cholesterol and lipid homeostasis [0.03%]
系统分析控制胆固醇和脂质稳态的功能基因
Haihuan Shan,Shuangshuang Fan,Quanrun Li et al.
Haihuan Shan et al.
Background: Dyslipidemia or hypercholesterolemia are among the main risk factors for cardiovascular diseases. Unraveling the molecular basis of lipid or cholesterol homeostasis would help to identify novel drug targets an...
A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients [0.03%]
COVID-19患者肝脏的单细胞核及空间转录组图谱揭示了器官在拓扑结构、功能和再生上的紊乱
Yered Pita-Juarez,Dimitra Karagkouni,Nikolaos Kalavros et al.
Yered Pita-Juarez et al.
Background: The molecular underpinnings of organ dysfunction in severe COVID-19 and its potential long-term sequelae are under intense investigation. To shed light on these in the context of liver function, we perform sin...
Integrative phenomics, metabolomics and genomics analysis provides new insights for deciphering the genetic basis of metabolism in polished rice [0.03%]
整合表型组学、代谢组学和基因组学分析为阐明抛光稻米新陈代谢的遗传基础提供了新的见解
Hui Feng,Yufei Li,Guoxin Dai et al.
Hui Feng et al.
Background: Metabolomics is one of the most widely used omics tools for deciphering the functional networks of the metabolites for crop improvement. However, it is technically demanding and costly. ...
mRNA m6A regulates gene expression via H3K4me3 shift in 5' UTR [0.03%]
mRNA的m6A通过在5'UTR上移动H3K4me3来调控基因表达
Yuna Yang,Yuqing Huang,Tian Wang et al.
Yuna Yang et al.
Background: N6-methyladenosine (m6A) is a prevalent and conserved RNA modification in eukaryotes. While its roles in the 3' untranslated regions (3' UTR) are well-studied, its role in the 5' UTR and its relationship with ...
Single-cell RNA-seq data have prevalent blood contamination but can be rescued by Originator, a computational tool separating single-cell RNA-seq by genetic and contextual information [0.03%]
单细胞RNA序列数据普遍存在血液污染，但可以被Originator rescue，这是一种通过遗传和背景信息分离单细胞RNA序列的计算工具。
为了更符合中文表达习惯，可以优化为：
单细胞RNA序列数据普遍受血液污染，可通过计算工具Originator基于遗传与背景信息进行修正。
Thatchayut Unjitwattana,Qianhui Huang,Yiwen Yang et al.
Thatchayut Unjitwattana et al.
Single-cell RNA sequencing (scRNA-seq) data from complex human tissues have prevalent blood cell contamination during the sample preparation process. They may also comprise cells of different genetic makeups. We propose a new computational ...
Recruitment and rejoining of remote double-strand DNA breaks for enhanced and precise chromosome editing [0.03%]
远程双链DNA断裂的招募和重新连接以提高和精确染色体编辑
Mingyao Wang,Pengchong Fu,Ziheng Chen et al.
Mingyao Wang et al.
Chromosomal rearrangements, such as translocations, deletions, and inversions, underlie numerous genetic diseases and cancers, yet precise engineering of these rearrangements remains challenging. Here, we present a CRISPR-based homologous r...
Yang Qiu,Lifen Liu,Jiali Yan et al.
Yang Qiu et al.
Background: Identifying transcriptional cis-regulatory elements (CREs) and understanding their role in gene expression are essential for the precise manipulation of gene expression and associated phenotypes. This knowledg...
Trans-ancestral rare variant association study with machine learning-based phenotyping for metabolic dysfunction-associated steatotic liver disease [0.03%]
与代谢功能障碍相关脂肪肝疾病机器学习表型的跨祖先罕见变异关联研究
Robert Chen,Ben Omega Petrazzini,Áine Duffy et al.
Robert Chen et al.
Background: Genome-wide association studies (GWAS) have identified common variants associated with metabolic dysfunction-associated steatotic liver disease (MASLD). However, rare coding variant studies have been limited b...
Meta-Analysis
Genome biology. 2025 Mar 10;26(1):50. DOI:10.1186/s13059-025-03518-5 2025