Phase-separating fusion proteins drive cancer by upsetting transcription regulation [0.03%]
相分离融合蛋白通过扰乱转录调控驱动癌症发生
Nazanin Farahi,Tamas Lazar,Peter Tompa et al.
Nazanin Farahi et al.
Background: Numerous cellular processes rely on biomolecular condensates formed through liquid-liquid phase separation (LLPS). Recently, it has become evident that somatic mutations can interfere with or over-activate the...
Phase-separating fusion proteins drive cancer by upsetting transcription regulation [0.03%]
相分离融合蛋白通过扰乱转录调控驱动癌症发病
Nazanin Farahi,Tamas Lazar,Peter Tompa et al.
Nazanin Farahi et al.
Background: Numerous cellular processes rely on biomolecular condensates formed through liquid-liquid phase separation (LLPS). Recently, it has become evident that somatic mutations can interfere with or over-activate the...
WUSCHEL-dependent chromatin regulation in maize inflorescence development at single-cell resolution [0.03%]
单细胞分辨率的玉米穗发育过程中WUSCHEL依赖的染色质调控
Sohyun Bang,Xuan Zhang,Jason Gregory et al.
Sohyun Bang et al.
Background: WUSCHEL (WUS) is a homeodomain transcription factor vital for stem cell proliferation in plant meristems. In maize, ZmWUS1 is expressed in the inflorescence meristem, including the central zone reservoir of st...
WUSCHEL-dependent chromatin regulation in maize inflorescence development at single-cell resolution [0.03%]
单细胞分辨率下拟南芥花序发育过程中WUSCHEL依赖的染色质调控
Sohyun Bang,Xuan Zhang,Jason Gregory et al.
Sohyun Bang et al.
Background: WUSCHEL (WUS) is a homeodomain transcription factor vital for stem cell proliferation in plant meristems. In maize, ZmWUS1 is expressed in the inflorescence meristem, including the central zone reservoir of st...
BLEND: probabilistic cellular deconvolution with individualized single-cell reference integration [0.03%]
BLEND：具有个性化单细胞参考整合的概率细胞去卷积
Penghui Huang,Manqi Cai,Chris McKennan et al.
Penghui Huang et al.
Cellular deconvolution estimates cell-type fractions from bulk transcriptomic data, but current methods often overlook cell type-specific expression varying across samples, discrepancies between bulk and single-cell data, or lack guidance o...
BLEND: probabilistic cellular deconvolution with individualized single-cell reference integration [0.03%]
BLEND：具有个性化单细胞参考集成的概率细胞去卷积
Penghui Huang,Manqi Cai,Chris McKennan et al.
Penghui Huang et al.
Cellular deconvolution estimates cell-type fractions from bulk transcriptomic data, but current methods often overlook cell type-specific expression varying across samples, discrepancies between bulk and single-cell data, or lack guidance o...
Phylogenomics provides comprehensive insights into the evolutionary relationships among cultivated buckwheat species [0.03%]
基于基因组的系统发生学研究揭示了栽培荞麦属作物之间的进化关系
Yaliang Shi,Bo Li,Yuanfen Gao et al.
Yaliang Shi et al.
Background: Buckwheat belongs to the family Polygonaceae and genus Fagopyrum, which is characterized by high flavonoid content, short growth period, and strong environmental adaptability. Buckwheat has three cultivated sp...
The rise of historical epigenomics and temporal analysis of gene regulation [0.03%]
历史表观基因组学的兴起及基因调控的时序分析
Clare E Holleley,Erin E Hahn
Clare E Holleley
Complex diseases driven by gene-environment interactions impose a heavy burden on human and animal health. Addressing these challenges requires innovative research. The emerging field of historical epigenomics offers a promising opportunity...
SDFA: a standardized decomposition format and toolkit for efficient analysis of structural variants in large-scale population genomic studies [0.03%]
SDFA：一种标准的分解格式和工具包，可高效分析大规模人群基因组研究中的结构变异
Wenjie Peng,Liubin Zhang,Bin Tang et al.
Wenjie Peng et al.
Structural variants (SVs) contribute significantly to genetic diversity yet present computational challenges during analysis. We introduce SDFA, a standardized decomposition format and toolkit for efficient analysis of SVs in large-scale po...
MOADE: a multimodal autoencoder for dissociating bulk multi-omics data [0.03%]
一种用于分解大批量多组学数据的多模态自动编码器模型
Jiao Sun,Ayesha A Malik,Tong Lin et al.
Jiao Sun et al.
In single cell biology, the complexity of tissues may hinder lineage cell mapping or tumor microenvironment decomposition, requiring digital dissociation of bulk tissues. Many deconvolution methods focus on transcriptomic assay, not easily ...