Functional genomic profiling of O-GlcNAc reveals its context-specific interplay with RNA polymerase II [0.03%]
O-糖胺聚糖的功能基因组分析显示其与RNA聚合酶II的特异性相互作用
Sofia Rucli,Nicolas Descostes,Yulia Ermakova et al.
Sofia Rucli et al.
Background: How reversible glycosylation of DNA-bound proteins acts on transcription remains scarcely understood. O-linked β-N-acetylglucosamine (O-GlcNAc) is the only known form of glycosylation modifying nuclear protei...
ASPM mediates nuclear entrapment of FOXM1 via liquid-liquid phase separation to promote progression of hepatocarcinoma [0.03%]
ASPM通过液-液相分离介导FOXM1的核滞留以促进肝癌进程
Xunliang Jiang,Jun Liu,Ke Wang et al.
Xunliang Jiang et al.
Background: Fork-head box protein M1 (FOXM1) plays critical roles in development and progression of multiple cancers, including hepatocellular carcinoma (HCC). However, the exact regulatory hierarchy of FOXM1 remains uncl...
aurora: a machine learning gwas tool for analyzing microbial habitat adaptation [0.03%]
Aurora：用于分析微生物栖息地适应性的机器学习GWAS工具
Dalimil Bujdoš,Jens Walter,Paul W O&#x;Toole
Dalimil Bujdoš
A primary goal of microbial genome-wide association studies is identifying genomic variants associated with a particular habitat. Existing tools fail to identify known causal variants if the analyzed trait shaped the phylogeny. Furthermore,...
Dissecting the genetic architecture of key agronomic traits in lettuce using a MAGIC population [0.03%]
利用MAGIC群体解析生菜关键农艺性状的遗传结构
Hongyun Chen,Jiongjiong Chen,Ruifang Zhai et al.
Hongyun Chen et al.
Background: Lettuce is a globally important leafy vegetable that exhibits diverse horticultural types and strong population structure, which complicates genetic analyses. To address this challenge, we develop the first mu...
scVAEDer: integrating deep diffusion models and variational autoencoders for single-cell transcriptomics analysis [0.03%]
scVAEDer：结合深度扩散模型和变分自编码器进行单细胞转录组学分析
Mehrshad Sadria,Anita Layton
Mehrshad Sadria
Discovering a lower-dimensional embedding of single-cell data can improve downstream analysis. The embedding should encapsulate both the high-level features and low-level variations. While existing generative models attempt to learn such lo...
Global profiling of CPL3-mediated alternative splicing reveals regulatory mechanisms of DGK5 in plant immunity and phosphatidic acid homeostasis [0.03%]
全局分析CPL3介导的选择性剪接揭示DGK5在植物免疫和磷脂酸稳态中的调控机制
Sung-Il Kim,Xiyu Ma,Liang Kong et al.
Sung-Il Kim et al.
Background: Alternative splicing of precursor mRNAs serves as a crucial mechanism to enhance gene expression plasticity for organismal adaptation. However, the precise regulation and function of alternative splicing in pl...
Analysis of 30 chromosome-level Drosophila genome assemblies reveals dynamic evolution of centromeric satellite repeats [0.03%]
对30个染色体级别的果蝇基因组装的分析揭示了着丝粒卫星重复动态演变的过程
Daniel Gebert,Amir D Hay,Jennifer P Hoang et al.
Daniel Gebert et al.
Background: The Drosophila genus is ideal for studying genome evolution due to its relatively simple chromosome structure and small genome size, with rearrangements mainly restricted to within chromosome arms, such as Mul...
Widespread impact of transposable elements on the evolution of post-transcriptional regulation in the cotton genus Gossypium [0.03%]
可移动元件对棉属Gossypium转录后调控进化产生的广泛影响
Xuehan Tian,Ruipeng Wang,Zhenping Liu et al.
Xuehan Tian et al.
Background: Transposable element (TE) expansion has long been known to mediate genome evolution and phenotypic diversity in organisms, but its impact on the evolution of post-transcriptional regulation following species d...
Exploring and mitigating shortcomings in single-cell differential expression analysis with a new statistical paradigm [0.03%]
探索并缓解单细胞差异表达分析中的不足的新统计范式
Chih-Hsuan Wu,Xiang Zhou,Mengjie Chen
Chih-Hsuan Wu
Background: Differential expression analysis is pivotal in single-cell transcriptomics for unraveling cell-type-specific responses to stimuli. While numerous methods are available to identify differentially expressed gene...
The haplotype-resolved genome assembly of an ancient citrus variety provides insights into the domestication history and fruit trait formation of loose-skin mandarins [0.03%]
古老柑橘品种的单倍型解析基因组装为揭示易剥皮橙的驯化历史和果实性状形成提供了见解
Minqiang Yin,Xiaochan Song,Chao He et al.
Minqiang Yin et al.
Background: Loose-skin mandarins (LSMs) are among the oldest domesticated horticultural crops, yet their domestication history and the genetic basis underlying the formation of key selected traits remain unclear. ...