A compendium of synthetic lethal gene pairs defined by extensive combinatorial pan-cancer CRISPR screening [0.03%]
大规模泛癌种CRISPR筛选鉴定合成致死基因对汇编
Victoria Harle,Victoria Offord,Birkan Gökbağ et al.
Victoria Harle et al.
Background: Synthetic lethal interactions are attractive therapeutic candidates as they enable selective targeting of cancer cells in which somatic alterations have disrupted one member of a synthetic lethal gene pair whi...
The 5-methylcytosine DNA glycosylase ROS1 prevents paternal genome hypermethylation in Arabidopsis endosperm [0.03%]
拟南芥胚乳中ROS1甲基胞嘧啶DNA糖基化酶可防止父本基因组高甲基化现象
Elizabeth A Hemenway,Mary Gehring
Elizabeth A Hemenway
Background: DNA methylation patterning is a consequence of opposing activities of DNA methyltransferases and DNA demethylases. In many plant and animal species, reproduction is a period of significant epigenome lability. ...
Systematic benchmarking of computational methods to identify spatially variable genes [0.03%]
系统评估计算方法识别空间可变性基因的能力
Zhijian Li,Zain M Patel,Dongyuan Song et al.
Zhijian Li et al.
Background: Spatially resolved transcriptomics offers unprecedented insight by enabling the profiling of gene expression within the intact spatial context of cells, effectively adding a new and essential dimension to data...
Yuxuan Song,Chengxin Zhang,Gilbert S Omenn et al.
Yuxuan Song et al.
Background: Protein structure prediction with neural networks is a powerful new method for linking protein sequence, structure, and function, but structures have generally been predicted for only a single isoform of each ...
A comprehensive benchmarking of adaptive sampling tools for nanopore sequencing [0.03%]
纳米孔测序自适应采样工具的全面基准测试
Lang Yang,Yanfeng Lin,Peihan Li et al.
Lang Yang et al.
Background: Adaptive sampling is an emerging technology to enrich target reads while depleting unwanted reads during real-time nanopore sequencing. The application of different algorithms has spawned various tools for the...
A hierarchical, count-based model highlights challenges in scATAC-seq data analysis and points to opportunities to extract finer-resolution information [0.03%]
分层计数模型揭示了单细胞ATAC测序数据中的挑战，并指出提取更精细分辨率信息的机会
Aaron Wing Cheung Kwok,Heejung Shim,Davis J McCarthy
Aaron Wing Cheung Kwok
Background: Data from Single-cell Assay for Transposase Accessible Chromatin with Sequencing (scATAC-seq) is highly sparse. While current computational methods feature a range of transformation procedures to extract meani...
Author Correction: cuteFC: regenotyping structural variants through an accurate and efficient force-calling method [0.03%]
作者更正：cuteFC：通过准确且高效的强制调用方法对结构变异进行再分型
Tao Jiang,Shuqi Cao,Yadong Liu et al.
Tao Jiang et al.
Published Erratum
Genome biology. 2025 Sep 15;26(1):280. DOI:10.1186/s13059-025-03726-z 2025
Diverse short tandem repeat sequences influence gene regulation in human populations [0.03%]
多种串联重复序列影响人类种群中的基因表达调控
Aleksandra Mitina,Worrawat Engchuan,Brett Trost et al.
Aleksandra Mitina et al.
Background: Short tandem repeat (STR) length is a known determinant of pathogenicity in a variety of human disorders. The repeat sequence itself can modulate disease severity and penetrance; however, the broader impact of...
Author Correction: Engineering novel CRISPRi repressors for highly efficient mammalian gene regulation [0.03%]
作者更正：工程化新型CRISPR干扰抑制物以实现高效的哺乳动物基因调控
Andrew Kristof,Krithika Karunakaran,Christopher Allen et al.
Andrew Kristof et al.
Published Erratum
Genome biology. 2025 Sep 12;26(1):278. DOI:10.1186/s13059-025-03746-9 2025
Single-cell atlas in the living fossil Yangtze sturgeon provides insight into the evolution of fish [0.03%]
活化石长江鲟单细胞图谱揭示鱼类进化历程
Yeyu Chen,Xiaoyun Wu,Jiansheng Lai et al.
Yeyu Chen et al.
Background: Fish are the largest group of vertebrates. Studying the characteristics, functions, and interactions of different fish cells is important for understanding their roles in disease and evolution. However, most s...