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期刊名:Genome biology

缩写:GENOME BIOL

ISSN:1474-760X

e-ISSN:1474-760X

IF/分区:9.4/Q1

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共收录本刊相关文章索引6360
Clinical Trial Case Reports Meta-Analysis RCT Review Systematic Review
Classical Article Case Reports Clinical Study Clinical Trial Clinical Trial Protocol Comment Comparative Study Editorial Guideline Letter Meta-Analysis Multicenter Study Observational Study Randomized Controlled Trial Review Systematic Review
Mei R M Du,Changqing Wang,Charity W Law et al. Mei R M Du et al.
Background: Spatial transcriptomics allows gene expression to be measured within complex tissue contexts. Among the array of spatial capture technologies available is 10x Genomics' Visium platform, a popular method which ...
Yuxuan Zhang,Wentao Zou,Yueyang Zhou et al. Yuxuan Zhang et al.
Background: Regulation of the target DNA cleavage activity of CRISPR/Cas has naturally evolved in a few bacteria or bacteriophages but is lacking in higher species. Thus, identification of bioactive agents and mechanisms ...
Devlin C Moyer,Justin Reimertz,Daniel Segrè et al. Devlin C Moyer et al.
Genome-scale metabolic models (GSMMs) are used to predict metabolic fluxes, with applications ranging from identifying novel drug targets to engineering microbial metabolism. Erroneous or missing reactions, scattered throughout densely inte...
Junwei Song,Li-An Lin,Chao Tang et al. Junwei Song et al.
Nanopore direct RNA sequencing (DRS) is a powerful tool for RNA biology but suffers from low basecalling accuracy, low throughput, and high input requirements. We present DEMINERS, a novel DRS toolkit combining an RNA multiplexing workflow,...
Sophie A Montandon,Pierre Beaudier,Asier Ullate-Agote et al. Sophie A Montandon et al.
Background: Snakes exhibit a broad variety of adaptive colors and color patterns, generated by the spatial arrangement of chromatophores, but little is known of the mechanisms responsible for these spectacular traits. Her...
Sojung Lee,Jayne A Barbour,Yee Man Tam et al. Sojung Lee et al.
Transposable elements (TEs) can influence human diseases by disrupting genome integrity, yet their quantification has been challenging due to the repetitive nature of these sequences across the genome. We develop LocusMasterTE, a method tha...
Qinwei Kim-Wee Zhuang,Klara Bauermeister,Jose Hector Galvez et al. Qinwei Kim-Wee Zhuang et al.
Background: Sex-biased gene regulation is the basis of sexual dimorphism in phenotypes and has been studied across different cell types and different developmental stages. However, sex-biased expression of transposable el...
Xin Wang,Kun Wang,Weixing Zhang et al. Xin Wang et al.
Background: Mitochondrial DNA (mtDNA) variants hold promise as endogenous barcodes for tracking human cell lineages, but their efficacy as reliable lineage markers are hindered by the complex dynamics of mtDNA in somatic ...