Asymmetric gene expression and cell-type-specific regulatory networks in the root of bread wheat revealed by single-cell multiomics analysis [0.03%]
单细胞多组学分析揭示了面包小麦根中不对称基因表达和细胞类型特异性调控网络
Lihua Zhang,Chao He,Yuting Lai et al.
Lihua Zhang et al.
Background: Homoeologs are defined as homologous genes resulting from allopolyploidy. Bread wheat, Triticum aestivum, is an allohexaploid species with many homoeologs. Homoeolog expression bias, referring to the relative ...
NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization [0.03%]
NSD2 E1099K通过破坏三维染色质组织驱动儿童急性淋巴细胞白血病复发
Sonali Narang,Nikki A Evensen,Jason Saliba et al.
Sonali Narang et al.
Background: The NSD2 p.E1099K (EK) mutation is shown to be enriched in patients with relapsed acute lymphoblastic leukemia (ALL), indicating a role in clonal evolution and drug resistance. ...
TrEMOLO: accurate transposable element allele frequency estimation using long-read sequencing data combining assembly and mapping-based approaches [0.03%]
基于长读测序数据的转座元件等位基因频率估计方法TrEMOLO：结合组装和映射的方法
Mourdas Mohamed,François Sabot,Marion Varoqui et al.
Mourdas Mohamed et al.
Transposable Element MOnitoring with LOng-reads (TrEMOLO) is a new software that combines assembly- and mapping-based approaches to robustly detect genetic elements called transposable elements (TEs). Using high- or low-quality genome assem...
BIND&MODIFY: a long-range method for single-molecule mapping of chromatin modifications in eukaryotes [0.03%]
黏附与修饰：用于原核生物染色质修饰单分子图谱的长读长方法
Zhe Weng,Fengying Ruan,Weitian Chen et al.
Zhe Weng et al.
Epigenetic modifications of histones are associated with development and pathogenesis of disease. Existing approaches cannot provide insights into long-range interactions and represent the average chromatin state. Here we describe BIND&MODI...
CRISPR screens identify gene targets at breast cancer risk loci [0.03%]
运用 CRISPR 筛选技术在乳腺癌风险区域寻找基因靶点
Natasha K Tuano,Jonathan Beesley,Murray Manning et al.
Natasha K Tuano et al.
Background: Genome-wide association studies (GWAS) have identified > 200 loci associated with breast cancer risk. The majority of candidate causal variants are in non-coding regions and likely modulate cancer risk by regu...
Helena L Crowell,Sarah X Morillo Leonardo,Charlotte Soneson et al.
Helena L Crowell et al.
Background: With the emergence of hundreds of single-cell RNA-sequencing (scRNA-seq) datasets, the number of computational tools to analyze aspects of the generated data has grown rapidly. As a result, there is a recurrin...
A translatome-transcriptome multi-omics gene regulatory network reveals the complicated functional landscape of maize [0.03%]
泛基因组转录组与翻译组联合分析绘制玉米复杂功能基因调控网络
Wanchao Zhu,Xinxin Miao,Jia Qian et al.
Wanchao Zhu et al.
Background: Maize (Zea mays L.) is one of the most important crops worldwide. Although sophisticated maize gene regulatory networks (GRNs) have been constructed for functional genomics and phenotypic dissection, a multi-o...
Iman Hajirasouliha,Stefan Semrau
Iman Hajirasouliha
The annual Genome Informatics conference was held at the Wellcome Genome Campus on September 21-23, 2022. The conference covered a remarkable range of topics of which we highlight a few in this report. ...
Shenghan Gao,Xiaofei Yang,Hongtao Guo et al.
Shenghan Gao et al.
Significant improvements in long-read sequencing technologies have unlocked complex genomic areas, such as centromeres, in the genome and introduced the centromere annotation problem. Currently, centromeres are annotated in a semi-manual wa...
Current sequence-based models capture gene expression determinants in promoters but mostly ignore distal enhancers [0.03%]
当前的序列模型能够捕获启动子中的基因表达特征，但忽略了远端增强子区域
Alexander Karollus,Thomas Mauermeier,Julien Gagneur
Alexander Karollus
Background: The largest sequence-based models of transcription control to date are obtained by predicting genome-wide gene regulatory assays across the human genome. This setting is fundamentally correlative, as those mod...