The spinach YY genome reveals sex chromosome evolution, domestication, and introgression history of the species [0.03%]
菠菜YY基因组揭示了其性染色体进化、驯化及杂交历史
Xiaokai Ma,Li&#x;ang Yu,Mahpara Fatima et al.
Xiaokai Ma et al.
Background: Spinach (Spinacia oleracea L.) is a dioecious species with an XY sex chromosome system, but its Y chromosome has not been fully characterized. Our knowledge about the history of its domestication and improveme...
TraSig: inferring cell-cell interactions from pseudotime ordering of scRNA-Seq data [0.03%]
TraSig：从scRNA-Seq数据的伪时间顺序推断细胞间相互作用
Dongshunyi Li,Jeremy J Velazquez,Jun Ding et al.
Dongshunyi Li et al.
A major advantage of single cell RNA-sequencing (scRNA-Seq) data is the ability to reconstruct continuous ordering and trajectories for cells. Here we present TraSig, a computational method for improving the inference of cell-cell interacti...
StrainGE: a toolkit to track and characterize low-abundance strains in complex microbial communities [0.03%]
一种用于在复杂微生物群落中跟踪和表征低丰度菌株的工具包
Lucas R van Dijk,Bruce J Walker,Timothy J Straub et al.
Lucas R van Dijk et al.
Human-associated microbial communities comprise not only complex mixtures of bacterial species, but also mixtures of conspecific strains, the implications of which are mostly unknown since strain level dynamics are underexplored due to the ...
Host-microbiome protein-protein interactions capture disease-relevant pathways [0.03%]
宿主微生物组蛋白质-蛋白质相互作用捕获与疾病相关的途径
Hao Zhou,Juan Felipe Beltrán,Ilana Lauren Brito
Hao Zhou
Background: Host-microbe interactions are crucial for normal physiological and immune system development and are implicated in a variety of diseases, including inflammatory bowel disease (IBD), colorectal cancer (CRC), ob...
Allele-specific expression reveals genes with recurrent cis-regulatory alterations in high-risk neuroblastoma [0.03%]
基于组织特异性表达的等位基因研究发现高危型神经母细胞瘤反复出现的调控区遗传变异
Arko Sen,Yuchen Huo,Jennifer Elster et al.
Arko Sen et al.
Background: Neuroblastoma is a pediatric malignancy with a high frequency of metastatic disease at initial diagnosis. Neuroblastoma tumors have few recurrent protein-coding mutations but contain extensive somatic copy num...
Meiosis-specific cohesin complexes display essential and distinct roles in mitotic embryonic stem cell chromosomes [0.03%]
专门用于减数分裂的粘连素在有丝分裂胚胎干细胞染色体中的不同功能及重要作用
Eui-Hwan Choi,Seobin Yoon,Young Eun Koh et al.
Eui-Hwan Choi et al.
Background: Cohesin is a chromosome-associated SMC-kleisin complex that mediates sister chromatid cohesion, recombination, and most chromosomal processes during mitosis and meiosis. However, it remains unclear whether mei...
Enhanced protein isoform characterization through long-read proteogenomics [0.03%]
通过长读长蛋白质组学改进蛋白质异构体特征描述
Rachel M Miller,Ben T Jordan,Madison M Mehlferber et al.
Rachel M Miller et al.
Background: The detection of physiologically relevant protein isoforms encoded by the human genome is critical to biomedicine. Mass spectrometry (MS)-based proteomics is the preeminent method for protein detection, but is...
Towards accurate and reliable resolution of structural variants for clinical diagnosis [0.03%]
准确而可靠地解决临床诊断中的结构变异问题
Zhichao Liu,Ruth Roberts,Timothy R Mercer et al.
Zhichao Liu et al.
Structural variants (SVs) are a major source of human genetic diversity and have been associated with different diseases and phenotypes. The detection of SVs is difficult, and a diverse range of detection methods and data analysis protocols...
TADA-a machine learning tool for functional annotation-based prioritisation of pathogenic CNVs [0.03%]
一种基于功能注释的优先排序病理拷贝数变异的机器学习工具(TADA)
Jakob Hertzberg,Stefan Mundlos,Martin Vingron et al.
Jakob Hertzberg et al.
Few methods have been developed to investigate copy number variants (CNVs) based on their predicted pathogenicity. We introduce TADA, a method to prioritise pathogenic CNVs through assisted manual filtering and automated classification, bas...
Insight into the ecology of vaginal bacteria through integrative analyses of metagenomic and metatranscriptomic data [0.03%]
整合宏基因组和宏转录组数据分析揭示阴道细菌生态学特征
Michael T France,Li Fu,Lindsay Rutt et al.
Michael T France et al.
Background: Vaginal bacterial communities dominated by Lactobacillus species are associated with a reduced risk of various adverse health outcomes. However, somewhat unexpectedly, many healthy women have microbiota that a...