FMRP-mediated spatial regulation of physiologic NMD targets in neuronal cells [0.03%]
神经细胞中生理NMD靶标的定位调控介导于FMRP
Tatsuaki Kurosaki,Xavier Rambout,Lynne E Maquat
Tatsuaki Kurosaki
In non-polarized cells, nonsense-mediated mRNA decay (NMD) generally begins during the translation of newly synthesized mRNAs after the mRNAs are exported to the cytoplasm. Binding of the FMRP translational repressor to UPF1 on NMD targets ...
Unraveling the phylogenomic diversity of Methanomassiliicoccales and implications for mitigating ruminant methane emissions [0.03%]
揭秘Methanomassiliicoccales的系统基因组多样性及其对缓解反刍动物甲烷排放的意义
Fei Xie,Shengwei Zhao,Xiaoxiu Zhan et al.
Fei Xie et al.
Background: Methanomassiliicoccales are a recently identified order of methanogens that are diverse across global environments particularly the gastrointestinal tracts of animals; however, their metabolic capacities are d...
SURGE: uncovering context-specific genetic-regulation of gene expression from single-cell RNA sequencing using latent-factor models [0.03%]
_SURGE：使用潜因子模型从单细胞RNA测序中揭示特定环境下的遗传调控规律_
Benjamin J Strober,Karl Tayeb,Joshua Popp et al.
Benjamin J Strober et al.
Genetic regulation of gene expression is a complex process, with genetic effects known to vary across cellular contexts such as cell types and environmental conditions. We developed SURGE, a method for unsupervised discovery of context-spec...
Structural variation and DNA methylation shape the centromere-proximal meiotic crossover landscape in Arabidopsis [0.03%]
结构变异和DNA甲基化塑造了拟南芥着丝粒附近减数分裂交换图谱
Joiselle B Fernandes,Matthew Naish,Qichao Lian et al.
Joiselle B Fernandes et al.
Background: Centromeres load kinetochore complexes onto chromosomes, which mediate spindle attachment and allow segregation during cell division. Although centromeres perform a conserved cellular function, their underlyin...
PICALO: principal interaction component analysis for the identification of discrete technical, cell-type, and environmental factors that mediate eQTLs [0.03%]
PICALO：用于识别介导eQTL的离散技术、细胞类型和环境因素的主要交互成分分析
Martijn Vochteloo,Patrick Deelen,Britt Vink;BIOS Consortium;Ellen A Tsai et al.
Martijn Vochteloo et al.
Expression quantitative trait loci (eQTL) offer insights into the regulatory mechanisms of trait-associated variants, but their effects often rely on contexts that are unknown or unmeasured. We introduce PICALO, a method for hidden variable...
DeepVelo: deep learning extends RNA velocity to multi-lineage systems with cell-specific kinetics [0.03%]
DeepVelo：深度学习扩展了多系系统中具有细胞特异性动力学的RNA速度
Haotian Cui,Hassaan Maan,Maria C Vladoiu et al.
Haotian Cui et al.
Existing RNA velocity estimation methods strongly rely on predefined dynamics and cell-agnostic constant transcriptional kinetic rates, assumptions often violated in complex and heterogeneous single-cell RNA sequencing (scRNA-seq) data. Usi...
Compact CRISPR genetic screens enabled by improved guide RNA library cloning [0.03%]
改进的guide RNA库克隆技术实现的紧凑型CRISPR基因筛选
Seok-Jin Heo,Lauren D Enriquez,Scot Federman et al.
Seok-Jin Heo et al.
CRISPR genome editing approaches theoretically enable researchers to define the function of each human gene in specific cell types, but challenges remain to efficiently perform genetic perturbations in relevant models. In this work, we deve...
Haplotype-resolved assembly of a tetraploid potato genome using long reads and low-depth offspring data [0.03%]
使用长读段和低深度后代数据解析四倍体马铃薯基因组的单倍体型组装
Rebecca Serra Mari,Sven Schrinner,Richard Finkers et al.
Rebecca Serra Mari et al.
Potato is one of the world's major staple crops, and like many important crop plants, it has a polyploid genome. Polyploid haplotype assembly poses a major computational challenge. We introduce a novel strategy for the assembly of polyploid...
Structure-primed embedding on the transcription factor manifold enables transparent model architectures for gene regulatory network and latent activity inference [0.03%]
基于转录因子流形的结构引导嵌入实现了用于基因调控网络和潜在活性推断的透明模型架构
Andreas Tjärnberg,Maggie Beheler-Amass,Christopher A Jackson et al.
Andreas Tjärnberg et al.
Background: Modeling of gene regulatory networks (GRNs) is limited due to a lack of direct measurements of genome-wide transcription factor activity (TFA) making it difficult to separate covariance and regulatory interact...
Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes [0.03%]
跨祖先全基因组关联研究青春期身高增长及与成人健康结果的共同遗传性
Jonathan P Bradfield,Rachel L Kember,Anna Ulrich et al.
Jonathan P Bradfield et al.
Background: Pubertal growth patterns correlate with future health outcomes. However, the genetic mechanisms mediating growth trajectories remain largely unknown. Here, we modeled longitudinal height growth with Super-Impo...