Engineered virus-like particle-assembled Vegfa-targeting Cas9 ribonucleoprotein treatment alleviates neovascularization in wet age-related macular degeneration [0.03%]
工程化的病毒样颗粒组装的靶向Vegfa的Cas9核糖核蛋白治疗可减轻湿性年龄相关性黄斑变性的新生血管化
Jun Wu,Hyewon Jang,Hyunjong Kwak et al.
Jun Wu et al.
Background: Age-related macular degeneration, particularly the wet form, is a leading cause of vision loss, characterized by vascular endothelial growth factor A (VEGFA) overproduction. Engineered virus-like particles (eV...
Multi-omics insights into microbiome-rumen epithelium interaction mechanisms underlying subacute rumen acidosis tolerance in dairy goats [0.03%]
多组学视角下微生物群-皱胃上皮相互作用机制在奶山羊亚急性皱胃酸中毒中的作用研究
Jingyi Xu,Xiaodong Chen,Jianrong Ren et al.
Jingyi Xu et al.
Background: To address rising demand for dairy products, dairy goats are often fed high-concentrate diets, which lead to subacute rumen acidosis (SARA). The mechanisms behind individual variation in SARA tolerance are not...
GIMIC: smoothed graph-image representation of microbiome samples induce an optimal distance [0.03%]
用于微生物组样品的平滑图像表示可诱导最佳距离GIMIC模型
Oshrit Shtossel,Yoram Louzoun
Oshrit Shtossel
An essential tool in microbiome is the distance between samples. This serves to detect groups of similar samples. We have recently shown that combining the cladogram with the abundance of each microbe into a sorted normalized abundance tree...
Evaluating the potential and limitations of nanopore adaptive sampling for targeted transcriptome sequencing [0.03%]
纳米孔自适应采样技术在靶向转录组测序中的潜力与局限性评估
Nicole DeBruyne,Feng Wang,Yang Xu et al.
Nicole DeBruyne et al.
Long-read RNA sequencing is a powerful technology for transcriptomics, but low throughput and high cost pose challenges. Adaptive sampling, a feature of Oxford Nanopore Technologies, offers real-time enrichment by selectively ejecting non-t...
Author Correction: MOADE: a multimodal autoencoder for dissociating bulk multi-omics data [0.03%]
作者更正：MOADE：一种多模态自动编码器用于分离多种组学数据的总体信息
Jiao Sun,Ayesha A Malik,Tong Lin et al.
Jiao Sun et al.
Published Erratum
Genome biology. 2025 Oct 9;26(1):348. DOI:10.1186/s13059-025-03826-w 2025
A molecular census to elucidate the demixing mechanism of membraneless organelles [0.03%]
一种分子普查，阐明膜-less细胞器的分相机制
Cheryn Ali,Fernando Muzzopappa,Fabian Erdel
Cheryn Ali
Background: Cells contain membraneless organelles that have been proposed to form via phase separation involving dense networks of multivalent intermolecular interactions. As it is notoriously difficult to experimentally ...
Agnieszka P Lipinska,Guillaume Cossard,Paul Epperlein et al.
Agnieszka P Lipinska et al.
Background: Sex chromosomes in red algae have remained relatively understudied, despite their fundamental role in understanding the evolution of sex determination across eukaryotes. In this study, we investigate the struc...
Pan-S-locus analysis reveals insights into the origin and evolution of self-incompatibility in the orange subfamily [0.03%]
泛S位点分析揭示了橙亚科自交不亲和性的起源与进化的新见解
Jianbing Hu,Zezhen Du,Chenchen Liu et al.
Jianbing Hu et al.
Background: Self-incompatibility is controlled by a highly polymorphic supergene complex, the S-locus, which is structurally complex, rich in repetitive sequences, and varies in length from hundreds of kilobases to tens o...
Sol Moe Lee,David C Goldberg,Cameron Cloud et al.
Sol Moe Lee et al.
Background: DNA cytosine modifications, including 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC), are key epigenetic regulators with distinct functions. Dissecting the ternary code (C, 5mC, 5hmC) across tissues...
High-precision cell-type mapping and annotation of single-cell spatial transcriptomics with STAMapper [0.03%]
基于STAMapper的单细胞空间转录组高精度细胞类型定位与注释
Qunlun Shen,Kangning Dong,Shuqin Zhang et al.
Qunlun Shen et al.
In this paper, we develop a heterogeneous graph neural network, STAMapper, to transfer the cell-type labels from single-cell RNA-sequencing (scRNA-seq) data to single-cell spatial transcriptomics (scST) data. We collect 81 scST datasets con...