Single-cell atlas in the living fossil Yangtze sturgeon provides insight into the evolution of fish [0.03%]
活化石长江鲟单细胞图谱揭示鱼类进化历程
Yeyu Chen,Xiaoyun Wu,Jiansheng Lai et al.
Yeyu Chen et al.
Background: Fish are the largest group of vertebrates. Studying the characteristics, functions, and interactions of different fish cells is important for understanding their roles in disease and evolution. However, most s...
MAGdb: a comprehensive high quality MAGs repository for exploring microbial metagenome-assemble genomes [0.03%]
MAGdb：一个全面且高质量的宏基因组拼接微生物基因组存储库以探索微生物群落
Guo Ye,Hao Hong,Ting Li et al.
Guo Ye et al.
Metagenomic analyses of microbial communities have unveiled a substantial level of interspecies and intraspecies genetic diversity by reconstructing metagenome-assembled genomes (MAGs). The MAG database (MAGdb) boasts an impressive collecti...
High-resolution time-series transcriptomic and metabolomic profiling reveals the regulatory mechanism underlying salt tolerance in maize [0.03%]
高通量时间序列转录组和代谢组揭示了玉米耐盐的调控机制
Fei Zhang,Boming Ji,Si Wu et al.
Fei Zhang et al.
Background: Soil salinization represents a critical global challenge to agricultural productivity, profoundly impacting crop yields and threatening food security. Plant salt-responsive is complex and dynamic, making it ch...
The systematic assessment of completeness of public metadata accompanying omics studies in the Gene Expression Omnibus data repository [0.03%]
系统评估基因表达数据仓库中组学研究的公共元数据的完备性
Yu-Ning Huang,Pooja Vinod Jaiswal,Anushka Rajes et al.
Yu-Ning Huang et al.
Background: Recent advances in high-throughput sequencing technologies have enabled the collection and sharing of a massive amount of omics data, along with its associated metadata-descriptive information that contextuali...
Patterns of extreme outlier gene expression suggest an edge of chaos effect in transcriptomic networks [0.03%]
极端异常基因表达模式表明转录组网络存在混沌边缘效应
Chen Xie,Sven Künzel,Wenyu Zhang et al.
Chen Xie et al.
Background: Most RNA-seq datasets harbor genes with extreme expression levels in some samples. Such extreme outliers are usually treated as technical errors and are removed from the data before further statistical analysi...
Distinct evolutionary trajectories of subgenomic centromeres in polyploid wheat [0.03%]
多倍体小麦次基因组着丝粒的进化轨迹区分化
Yuhong Huang,Yang Liu,Chang Liu et al.
Yuhong Huang et al.
Background: Centromeres are crucial for precise chromosome segregation and maintaining genome stability during cell division. However, their evolutionary dynamics, particularly in polyploid organisms with complex genomic ...
Bacillus drives functional states in synthetic plant root bacterial communities [0.03%]
芽孢杆菌驱动合成植物根系细菌群落的功能状态
Gijs Selten,Ronnie de Jonge
Gijs Selten
Background: Plant roots release root exudates to attract microbes that form root communities, which in turn promote plant health and growth. Root community assembly arises from millions of interactions between microbes an...
Meta-Analysis
Genome biology. 2025 Sep 9;26(1):270. DOI:10.1186/s13059-025-03739-8 2025
Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals [0.03%]
基于246,000人的全基因组序列分析低密度脂蛋白胆固醇变异的影响
Margaret Sunitha Selvaraj,Xihao Li,Zilin Li et al.
Margaret Sunitha Selvaraj et al.
Background: Rare genetic variation provided by whole genome sequence datasets has been relatively less explored for its contributions to human traits. Meta-analysis of sequencing data offers advantages by integrating larg...
Meta-Analysis
Genome biology. 2025 Sep 9;26(1):273. DOI:10.1186/s13059-025-03698-0 2025
DNA G-quadruplex profiling in skeletal muscle stem cells reveals functional and mechanistic insights [0.03%]
骨骼肌干细胞中的DNA G-四链体特征研究揭示了功能和机制方面的见解
Xiaona Chen,Feng Yang,Suyang Zhang et al.
Xiaona Chen et al.
Background: DNA G-quadruplexes (G4s) are non-canonical secondary structures formed in guanine-rich DNA sequences and play important roles in modulating biological processes through a variety of gene regulatory mechanisms....
Evolutionary diversification of ancestral genes across vertebrates and insects [0.03%]
脊椎动物和昆虫祖先基因的进化分化
Federica Mantica,Manuel Irimia
Federica Mantica
Background: Vertebrates and insects diverged approximately 700 million years ago, and yet they retain a large core of conserved genes from their last common ancestor. These ancient genes present strong evolutionary constr...