Epstein-Barr virus and multiple sclerosis: from associations to mechanisms to potential therapies [0.03%]
从相关性到机制再到潜在治疗方法：EB病毒与多发性硬化症的关系
Jan D Lünemann,Christian Münz
Jan D Lünemann
Background: Epstein-Barr virus, a widespread herpesvirus that establishes lifelong latency after primary infection, has emerged in serological and epidemiological studies as a strong and consistent risk factor for multipl...
Clinical presentations and pathophysiological mechanisms of dystroglycanopathy: advancing therapeutic strategies [0.03%]
肌糖蛋白病的临床表现、病理生理机制及治疗方法的研究进展
Ameya S Walimbe,Francesco Muntoni,Kevin P Campbell
Ameya S Walimbe
Dystroglycanopathies are muscular dystrophies with varying clinical severities, ranging from congenital-onset to adult limb-girdle muscular dystrophy. Dystroglycanopathies are caused by a loss of function of the extracellular matrix recepto...
Bruton's tyrosine kinase inhibitors: a new class of multiple sclerosis therapeutics [0.03%]
布鲁顿酪氨酸激酶抑制剂：多发性硬化症治疗的新药类群
Jiwon Oh,Amit Bar-Or,Xavier Montalban et al.
Jiwon Oh et al.
Bruton's tyrosine kinase (BTK) is an intracellular enzyme involved in a wide range of cellular functions. BTK inhibitors (BTKIs) are of interest in multiple sclerosis because they modulate various types of immune cells that have key roles i...
Spontaneous spinal CSF leaks: a rare variant exome sequencing study and functional analysis [0.03%]
自发性脊柱脑脊液漏的外显子组测序及功能分析研究
Cassie A Parks,Mukti Singh,Elizabeth Wohler et al.
Cassie A Parks et al.
Background: Spontaneous spinal CSF leaks are associated with connective tissue diseases including Marfan syndrome and Loeys-Dietz syndrome, which are caused by mutations in genes that influence the content and integrity o...
Safety and efficacy of staged, bilateral magnetic resonance-guided focused ultrasound pallidothalamic tractotomy for motor complications of Parkinson's disease: a prospective, multicentre, single-arm trial [0.03%]
用于帕金森病运动并发症的分期双侧磁共振引导聚焦超声丘脑腹中间核治疗的安全性和疗效：一项前瞻性多中心单组试验
Arif Dalvi,Howard M Eisenberg,Peihan Wu et al.
Arif Dalvi et al.
Background: Parkinson's disease management is often complicated by motor fluctuations and dyskinesia. Although deep brain stimulation addresses these symptoms, its use is limited by invasiveness, potential device failure,...
Clinical Trial
The Lancet. Neurology. 2026 Jul;25(7):654-663. DOI:10.1016/S1474-4422(26)00142-0 2026
Safety and efficacy of decompressive craniectomy versus standard craniotomy for large acute epidural haematoma with tentorial herniation in China (PREDICT-AEDH): a nationwide, multicentre, open-label, parallel-group, randomised controlled trial [0.03%]
中国大型急性硬膜外血肿伴小脑幕切迹疝患者减压术与标准开颅术疗效和安全性的评估(PREDICT-AEDH)：一项全国多中心开放标签平行组随机对照试验
Junfeng Feng,Chun Yang,Li Xie et al.
Junfeng Feng et al.
Background: Decompressive craniectomy has been widely evaluated across heterogeneous types of brain injury but its effect in patients with large acute epidural haematoma complicated by tentorial herniation remains unclear...
Randomized Controlled Trial
The Lancet. Neurology. 2026 Jul;25(7):645-653. DOI:10.1016/S1474-4422(26)00143-2 2026