André Veillette,Jiaxin Li,Cristian Camilo Galindo et al.
André Veillette et al.
The ability of macrophages to eliminate cancer cells through phagocytosis is tightly controlled by pro-phagocytic and inhibitory phagocytic receptors. Pro-phagocytic receptors such as Fc receptors, macrophage-1 antigen (MAC-1; also known as...
The impact of concomitant medications on treatment outcomes in patients with cancer receiving immune checkpoint inhibitors [0.03%]
合并用药对接受免疫检查点抑制剂治疗的癌症患者疗效的影响
Samantha Stone,Jordan P McPherson,Rajan P Kulkarni et al.
Samantha Stone et al.
During anticancer therapy, patients with cancer are often prescribed medications to combat concomitant health conditions and ameliorate cancer-associated side effects. Despite emerging evidence that many commonly prescribed medications have...
Yaoyi Dai,Shuai Guo,Yidan Pan et al.
Yaoyi Dai et al.
Cancer tissues are heterogeneous mixtures of tumour, stromal and immune cells, where each component comprises multiple distinct cell types and/or states. Mapping this heterogeneity and understanding the unique contributions of each cell typ...
Gabrielle Brewer
Gabrielle Brewer
Daolin Tang,Jiayi Wang,Guido Kroemer et al.
Daolin Tang et al.
Macropinocytosis is a nutrient-scavenging process that enables cells to engulf large volumes of extracellular fluid and solutes through dynamic plasma membrane ruffling. In cancer, this evolutionarily conserved process is frequently hijacke...
Patricia Basurto-Lozada,Carla Daniela Robles-Espinoza
Patricia Basurto-Lozada
Muhammad H Shahzad,Roni F Rayes,Jonathan Cools-Lartigue et al.
Muhammad H Shahzad et al.
Within the tumour immune microenvironment (TIME), neutrophils can undergo NETosis to release neutrophil extracellular traps (NETs), which are protein-decorated DNA webs that promote cancer progression, metastasis and immune evasion. NETs pr...
Daniela Senft
Daniela Senft
Tae Gun Kang,Jordan T Johnson,Caitlin C Zebley et al.
Tae Gun Kang et al.
Current T cell-based immunotherapy strategies, including immune checkpoint blockade (ICB) and chimeric antigen receptor (CAR) T cells, have revolutionized cancer care. However, many patients with cancer who are treated with these approaches...
Mechanisms, challenges and opportunities for FLASH radiotherapy in cancer [0.03%]
超分割放射治疗在癌症治疗中的机制、挑战与机遇
Marie-Catherine Vozenin,Pierre Montay-Gruel,Pelagia Tsoutsou et al.
Marie-Catherine Vozenin et al.
FLASH radiotherapy has the potential to improve both patient quality of life and outcomes by delivering radiation at ultrahigh dose rates to effectively target tumours while sparing healthy tissues. However, the differential sensitivity of ...