Sheng Hong,Guo-Min Li
Sheng Hong
The DNA damage response (DDR) and immune system serve as critical defence mechanisms, safeguarding genomic integrity and providing host protection, respectively. Emerging research reveals their interconnection in dictating the response to c...
Johanna A Joyce
Johanna A Joyce
Xin Liu,Elena Goldberg,Jonathan C Kagan et al.
Xin Liu et al.
Gasdermins (GSDMs) are a family of pore-forming proteins that execute pyroptosis, a lytic form of programmed cell death associated with membrane rupture. This function of GSDMs was initially identified from studies of gasdermin D (GSDMD), w...
J Omar Muñoz-Bello,Marcela Lizano
J Omar Muñoz-Bello
Gabrielle Brewer
Gabrielle Brewer
Daniela Senft
Daniela Senft
Escaping the trap [0.03%]
摆脱陷阱
Daniela Senft
Daniela Senft
A genomic and epigenomic lens into the biology of acute lymphoblastic leukaemia [0.03%]
从基因组和表观基因组角度探究急性淋巴细胞白血病的生物学特性
Ilaria Iacobucci,Charles G Mullighan
Ilaria Iacobucci
Acute lymphoblastic leukaemia (ALL) is characterized by uncontrolled proliferation of lymphoid progenitor cells. Advances in genomic and epigenomic profiling have enabled the identification of over 40 molecular subtypes defined by distinct ...
Systemic health impact of cancer-associated extracellular vesicles and particles [0.03%]
癌症相关外泌体和颗粒的全身健康影响
Gang Wang,Serena Lucotti,Linda Bojmar et al.
Gang Wang et al.
Cancer is a systemic disease that perturbs the homeostasis of host tissues and organs, exerting manifestations both locally and distantly. Extracellular vesicles and particles (EVPs) have a pivotal role in intercellular communication betwee...
Jan Grimm,Fabian Kiessling,Kevin M Brindle et al.
Jan Grimm et al.
The hallmarks of cancer were introduced by Hanahan and Weinberg as a conceptual organizing framework to distil the complexity of tumours. This concept of cancer hallmarks has become an enduring theme in cancer research. Moreover, an increas...