Amanda C Doran,Arif Yurdagul Jr,Ira Tabas
Amanda C Doran
The clearance of apoptotic cells by professional and non-professional phagocytes - a process termed 'efferocytosis' - is essential for the maintenance of tissue homeostasis. Accordingly, defective efferocytosis underlies a growing list of c...
Lionel B Ivashkiv
Lionel B Ivashkiv
Hypoxia and glycolysis have long been appreciated to promote immune cell activation. In 2019, several studies highlighted a counterbalancing homeostatic function for the glycolytic metabolite lactate. Lactate directly suppresses signalling ...
Caroline Raffin,Linda T Vo,Jeffrey A Bluestone
Caroline Raffin
Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In this Review, we discuss the biology of Treg cells a...
Andreas Handel,Nicole L La Gruta,Paul G Thomas
Andreas Handel
The immune system is inordinately complex with many interacting components determining overall outcomes. Mathematical and computational modelling provides a useful way in which the various contributions of different immunological components...
Peter J Murray
Peter J Murray
Noam Kadouri,Shir Nevo,Yael Goldfarb et al.
Noam Kadouri et al.
The generation of a functional T cell repertoire in the thymus is mainly orchestrated by thymic epithelial cells (TECs), which provide developing T cells with cues for their navigation, proliferation, differentiation and survival. The TEC c...
Cecilia Domínguez Conde,Sarah A Teichmann
Cecilia Domínguez Conde
Kirsty Minton
Kirsty Minton
Alexandra Flemming
Alexandra Flemming
Yvonne Bordon
Yvonne Bordon