Blocking SIRPα could restore macrophage appetite and mitigate pneumonia [0.03%]
阻断SIRPα可恢复巨噬细胞的“食欲”并缓解肺炎并发症
Yvonne Bordon
Yvonne Bordon
Peter Aaby,Christine Stabell Benn,Katie L Flanagan et al.
Peter Aaby et al.
The textbook view of vaccination is that it functions to induce immune memory of the specific pathogen components of the vaccine, leading to a quantitatively and qualitatively better response if the host is exposed to infection with the sam...
Myvizhi Esai Selvan
Myvizhi Esai Selvan
Alvaro Moreira
Alvaro Moreira
Verena van der Heide
Verena van der Heide
Katherine Whalley
Katherine Whalley
Dhiraj Acharya,GuanQun Liu,Michaela U Gack
Dhiraj Acharya
Infection with SARS-CoV-2 can lead to excessive production of pro-inflammatory cytokines, but the production of type I interferons, which are key antiviral mediators, is reportedly blunted. Here, we discuss how imbalanced interferon respons...
Laure-Anne Teuwen,Vincent Geldhof,Alessandra Pasut et al.
Laure-Anne Teuwen et al.
On the basis of emerging evidence from patients with COVID-19, we postulate that endothelial cells are essential contributors to the initiation and propagation of severe COVID-19. Here, we discuss current insights into the link between endo...
A guide to cancer immunotherapy: from T cell basic science to clinical practice [0.03%]
癌症免疫疗法指南：从T细胞基础科学到临床实践
Alex D Waldman,Jill M Fritz,Michael J Lenardo
Alex D Waldman
The T lymphocyte, especially its capacity for antigen-directed cytotoxicity, has become a central focus for engaging the immune system in the fight against cancer. Basic science discoveries elucidating the molecular and cellular biology of ...
Nicholas M Adams,Simon Grassmann,Joseph C Sun
Nicholas M Adams
One of the hallmarks of the vertebrate adaptive immune system is the prolific expansion of individual cell clones that encounter their cognate antigen. More recently, however, there is growing evidence for the clonal expansion of innate lym...