Type I interferonopathy in ATR-X syndrome reveals a transcriptional role for cGAS [0.03%]
ATR-X综合征中I型干扰素反应异常揭示了cGAS的转录调控功能
Rachel Geltman,Dusan Bogunovic
Rachel Geltman
Leon Baronijan,Alberto Martin
Leon Baronijan
Beyond suppression: the paradox of JAK inhibitors as amplifiers of cancer immunotherapy [0.03%]
兼论JAK抑制剂在癌症免疫治疗中的放大效应
Jaroslav Zak,John R Teijaro
Jaroslav Zak
JAK inhibitors target a large group of cytokines that signal through the JAK-STAT pathway and are typically used clinically as immunosuppressive agents. However, recent work has demonstrated the paradoxical ability of JAK inhibitors to enha...
How crosstalk at the immune synapse shapes T cell and dendritic cell biologys [0.03%]
免疫突触的串扰如何塑造T细胞和树突状细胞生物学属性
Noa B Martín-Cófreces,Diego Calzada-Fraile,Francisco Sánchez-Madrid
Noa B Martín-Cófreces
In the context of adaptive immunity, T cells are activated by professional antigen-presenting cells (APCs) in a process that begins with peptide-MHC complexes on the APC being recognized by T cell receptor and CD3 co-receptor complexes on t...
Lucy Bird
Lucy Bird
Segmented filamentous bacteria in the gut protect against secondary bacterial infections in the lung [0.03%]
肠道中的分段丝状细菌可保护肺部免受继发性细菌感染
Alexandra Flemming
Alexandra Flemming
RNA-binding proteins and ribonucleoproteins as determinants of immunity [0.03%]
作为免疫决定因子的核糖核酸结合蛋白和核糖核蛋白
Martin Turner,Georg Petkau
Martin Turner
Infection triggers one of the most dramatic systemic responses in the body, and the coordinated activation and function of immune cells requires a dynamic regulation of transcriptomes and proteomes. This is achieved by RNA-binding proteins,...
Yvonne Bordon
Yvonne Bordon
Sensory neurons promote allergic sensitization and cross-sensitization via mTORC1 [0.03%]
感觉神经元通过mTORC1促进过敏和交叉过敏反应
Frederika Rentzeperis,Brian Kim
Frederika Rentzeperis