Nicholas W Lukacs,Simon P Hogan
Nicholas W Lukacs
Food allergy is an acute IgE-mediated reaction that occurs in response to food components and affects 1-10% of the global population. It is often thought to be a disease of the gastrointestinal tract, in which oral exposure to a food allerg...
Boyan K Tsankov,Dana J Philpott
Boyan K Tsankov
Yael Alippe,Joshua Hatterschide,Carolyn B Coyne et al.
Yael Alippe et al.
During pregnancy, the maternal immune system must navigate a balance between fetal tolerance and a response to acquired microbial infections. Cells at the maternal-fetal interface coordinate this response throughout gestational stages in a ...
Iron and the immune system [0.03%]
铁与免疫系统
Joe N Frost,Hal Drakesmith
Joe N Frost
Iron is a cofactor for hundreds of enzymes and biochemical processes that support cellular metabolism across the kingdoms of life. Because of this, the host and pathogen compete for iron as a vital resource. Moreover, research has shown tha...
Finding and filling the knowledge gaps in mechanisms of T cell-mediated TB immunity to inform vaccine design [0.03%]
填补T细胞介导的结核病免疫机制的认识空白以指导疫苗设计
Emma Lefrançais,Denis Hudrisier,Olivier Neyrolles et al.
Emma Lefrançais et al.
Mycobacterium tuberculosis, the bacterium that causes tuberculosis (TB), results in more human mortality than any other single pathogen, in part because of the lack of an effective vaccine. Although T cells are essential for immunity to TB,...
Lily Keane,Gerard Clarke,John F Cryan
Lily Keane
Microglia, the resident immune cells of the brain, are now recognized as being active participants in the onset and progression of many neurological and neuropsychiatric disorders. As a result, substantial effort has been made in finding wa...
Benjamin R Schrank,Betty Y S Kim
Benjamin R Schrank
Brian Y Soong,Miriam Merad
Brian Y Soong
Jacques Behmoaras,Kevin Mulder,Florent Ginhoux et al.
Jacques Behmoaras et al.
Macrophages are active participants of tissue repair and when normal repair processes fail, fibrosis can ensue, which leads to major organ dysfunction and affects nearly a billion people worldwide. Here we focus on macrophages in the spatio...