Abel Plaza-Florido,Pedro Carrera-Bastos,Inmaculada Pérez-Prieto et al.
Abel Plaza-Florido et al.
Centenarians - individuals aged 100 years or older - constitute a biologically distinct human population that achieves exceptional longevity while frequently retaining functional independence and avoiding major age-related diseases or postp...
Christian R Engwerda,Paul M Kaye,Simona Stäger
Christian R Engwerda
Leishmania are intracellular protozoan parasites transmitted to humans by the bite of infected phlebotomine sand flies. Human infection is often asymptomatic but can develop into a broad spectrum of clinical diseases, collectively termed th...
Liangliang Ji,Jiaxin Li,Ting-Wei Hsu et al.
Liangliang Ji et al.
Monocytes and macrophages are versatile immune sentinels that are present in nearly all tissues, where they continually adapt to local cues. In cancer, their functions are context-dependent - often linked to tumour growth and poor prognosis...
Metabolite and nutrient regulation of macrophages in obesity and metabolic disease [0.03%]
肥胖和代谢性疾病中代谢物和营养物质对巨噬细胞的调节作用
Neil T Sprenkle,Evanna L Mills
Neil T Sprenkle
Tissue-resident macrophages are crucial sentinel cells of the innate immune system that sense nutrient fluctuations and orchestrate adaptive responses to support steady-state metabolic homeostasis. When dysregulated, these cells have major ...
Ina Rudloff,Michael Christie,Nadia S Deen et al.
Ina Rudloff et al.
Cytokines are essential mediators of immune functions and regulate many other biological processes, ranging from fetal development to ageing. Dysregulation of cytokine responses can substantially increase the risk of disease and so their ac...
Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers [0.03%]
肝稳态和疾病中的枯氏细胞：从免疫哨兵到代谢门卫
Bruna Araujo David,Francesco Andreata,Camille Blériot et al.
Bruna Araujo David et al.
The liver, a key metabolic organ, has a central role in maintaining systemic homeostasis but is vulnerable to numerous diseases. Its metabolic functions are mainly carried out by hepatocytes; however, the liver also harbours diverse non-par...
Kirsty Minton
Kirsty Minton
Yvonne Bordon
Yvonne Bordon
Inhibition of NR4A1 potentiates a CD8+ T cell response against active tuberculosis [0.03%]
NR4A1的抑制可增强CD8⁺T细胞对活动性结核病的反应
Guillaume J Trusz,Christopher Sundling
Guillaume J Trusz
Leo Swadling,Valeria Fumagalli,Mala K Maini et al.
Leo Swadling et al.