Emery Hoos,Malcolm J W Sim
Emery Hoos
Inflame and restrain - the paradoxical roles of IL-12 and IL-23 in immunity [0.03%]
炎性和抑制作用-IL-12和IL-23在免疫中的矛盾角色
Lukas Rindlisbacher,Maria N Navarro,Burkhard Becher
Lukas Rindlisbacher
Within the IL-12 superfamily of heterodimeric cytokines, IL-12 and IL-23, which share a subunit, are among the most pro-inflammatory members. Both are primarily produced by phagocytes and have key roles in activating and regulating T lympho...
Biochemical signals from the extracellular matrix in inflammation and tumour immunology [0.03%]
炎症和肿瘤免疫学中来自细胞外基质的生化信号
Lydia Sorokin
Lydia Sorokin
The extracellular matrix (ECM) constitutes the bulk between cells, establishes barriers that separate tissue compartments, and defines the form and pliability of organs. The ECM is an integral part of the cellular microenvironment, conveyin...
Declan Pang,Alice Bertocchi,Fiona Powrie et al.
Declan Pang et al.
The immune system has evolved intricate and sophisticated mechanisms to recognize and eliminate tumours. Among these, T helper 17 (TH17) cells seem to have a complex role in tumour immunity. Substantial evidence indicates that TH17 cells ca...
Ubiquitination and autophagy in host-pathogen interactions: from immune surveillance to therapeutic targeting [0.03%]
宿主与病原相互作用中的泛素化和自噬：从免疫监视到靶向治疗
João Mello-Vieira,Ivan Dikic
João Mello-Vieira
Ubiquitination, the covalent attachment of ubiquitin to proteins and other cellular substrates, is a dynamic post-translational modification that enables cells to rapidly respond to internal and external threats. Beyond its canonical role i...
Sara Lamorte,Tracy L McGaha
Sara Lamorte
Mary Jo Turk,Yina H Huang
Mary Jo Turk
Vitiligo is an autoimmune disease of melanocyte destruction, which manifests as progressive, patchy loss of pigmentation in the skin. As one of most common autoimmune diseases, vitiligo inflicts a significant psychosocial burden. Research o...
Publisher Correction: Fifty years of monoclonals: the past, present and future of antibody therapeutics [0.03%]
正刊更正：单克隆抗体的五十年：抗体疗法的过去、现在和未来
Andrew C Chan,Greg D Martyn,Paul J Carter
Andrew C Chan
Published Erratum
Nature reviews. Immunology. 2025 Dec 15. DOI:10.1038/s41577-025-01261-3 2025
Lucy Bird
Lucy Bird
Parental allergy and early life infection combine to promote asthma in childhood [0.03%]
父母过敏和生命早期感染联合促进儿童哮喘
Yvonne Bordon
Yvonne Bordon