Alexandra Flemming
Alexandra Flemming
Enterobacteriaceae-derived cadaverine manipulates gut macrophage metabolism [0.03%]
肠杆菌科来源的尸胺可调节肠道巨噬细胞代谢
Alexandra Flemming
Alexandra Flemming
Jasia Mahdi,Vrunda Trivedi,Michelle Monje
Jasia Mahdi
The nervous and immune systems are intricately linked to one another through bi-directional crosstalk. Given the limited therapeutic options for aggressive and refractory central nervous system (CNS) tumours, immunotherapies are increasingl...
Kirsty Minton
Kirsty Minton
Qinli Sun,Chen Dong
Qinli Sun
T cell exhaustion is an adaptive and distinct cell fate that emerges in response to persistent antigen stimulation, primarily in chronic infections and cancer. It is characterized by a progressive loss of effector functions and sustained ex...
Rayne H Rouce
Rayne H Rouce
Lessons from neoadjuvant immunotherapy in melanoma: understanding antitumour immunity and tumour escape [0.03%]
免疫治疗应用于黑色素瘤的新辅助治疗的启示：理解抗肿瘤免疫和肿瘤逃逸机制
Francesca Fallarino,Christian U Blank
Francesca Fallarino
Immunotherapy has become a fourth pillar of cancer therapy, alongside surgery, radiotherapy and chemotherapy. Cancer immunotherapy seems to be most effective in the context of low but not negligible tumour burden, thus in the neoadjuvant se...
Targets of protective immunity and opportunities in hepatitis C virus vaccine development [0.03%]
保护性免疫的作用目标及开发丙型肝炎疫苗的新策略
Seung Bum Park,Paul Zimmer-Harwood,T Jake Liang
Seung Bum Park
Hepatitis C virus (HCV) remains a serious global health burden that affects nearly 50 million people worldwide. Despite the availability of highly effective direct-acting antiviral drugs, the lack of an effective HCV vaccine hinders control...
Immune-related actinopathies at the cross-road of immunodeficiency, autoimmunity and autoinflammation [0.03%]
免疫缺陷、自身免疫和炎性自体免疫相交处的与免疫有关的肌动蛋白病
Loïc Dupré,Irinka Castanon,Kaan Boztug
Loïc Dupré
Actin cytoskeleton remodelling drives the migration of immune cells and their engagement in dynamic cell-cell contacts. The importance of actin cytoskeleton dynamics in immune cell function is highlighted by the discovery of inborn errors o...
Thomas Riffelmacher,Mitchell Kronenberg
Thomas Riffelmacher
Immunometabolism, the intersection of cellular metabolism and immune function, has revolutionized our understanding of T cell biology. Changes in cellular metabolism help guide the development of thymocytes and the transition of T cells fro...