Shelley Herbrich,Padmanee Sharma
Shelley Herbrich
How T cells handle lipids [0.03%]
T细胞如何处理脂质
Lucy Bird
Lucy Bird
Kirsty Minton
Kirsty Minton
Kai Li,David M Underhill
Kai Li
The process of phagocytosis creates intracellular compartments (organelles known as phagosomes) that are central hubs for innate immune sensing of potentially dangerous microorganisms, cells, cellular debris and foreign objects. Receptors, ...
Alaz Ozcan,Tommaso Vicanolo,Veronique Angeli et al.
Alaz Ozcan et al.
The concept of structural immunity, as defined in this Perspective, posits that the first line of immune defence against foreign agents and tissue damage involves the preventative, physical reinforcement of tissue barriers and that this fun...
Astroimmunology: the effects of spaceflight and its associated stressors on the immune system [0.03%]
航天免疫学：空间飞行及其相关应激因素对免疫系统的影响
Daniel A Winer,Huixun Du,JangKeun Kim et al.
Daniel A Winer et al.
As humans embark on longer and deeper missions into space, it is crucial to understand how spaceflight impacts the immune system. Decades of discoveries, bolstered by recent multiomic analyses, have identified key immune processes that are ...
Microenvironmental regulation of solid tumour resistance to CAR T cell therapy [0.03%]
肿瘤细胞微环境对CAR-T细胞治疗抗性的作用机制研究
Zachary L Lamplugh,Nils Wellhausen,Carl H June et al.
Zachary L Lamplugh et al.
Chimeric antigen receptor (CAR) T cell therapy holds significant promise for the treatment of cancer; however, its efficacy in solid tumours is substantially hindered by the immunosuppressive tumour microenvironment (TME). Solid tumours can...
Jeremy G Baldwin,Christoph Heuser-Loy,Luca Gattinoni
Jeremy G Baldwin
Organelles are the internal batteries, gears, actuators, 3D printers and transmitters that drive cell function. Their composition and activity vary between cell types depending on functional demands. In T cells, which are key mediators of i...
Yvonne Bordon
Yvonne Bordon
Alexandra Flemming
Alexandra Flemming