Leon Baronijan,Alberto Martin
Leon Baronijan
Beyond suppression: the paradox of JAK inhibitors as amplifiers of cancer immunotherapy [0.03%]
兼论JAK抑制剂在癌症免疫治疗中的放大效应
Jaroslav Zak,John R Teijaro
Jaroslav Zak
JAK inhibitors target a large group of cytokines that signal through the JAK-STAT pathway and are typically used clinically as immunosuppressive agents. However, recent work has demonstrated the paradoxical ability of JAK inhibitors to enha...
How crosstalk at the immune synapse shapes T cell and dendritic cell biologys [0.03%]
免疫突触的串扰如何塑造T细胞和树突状细胞生物学属性
Noa B Martín-Cófreces,Diego Calzada-Fraile,Francisco Sánchez-Madrid
Noa B Martín-Cófreces
In the context of adaptive immunity, T cells are activated by professional antigen-presenting cells (APCs) in a process that begins with peptide-MHC complexes on the APC being recognized by T cell receptor and CD3 co-receptor complexes on t...
Lucy Bird
Lucy Bird
Segmented filamentous bacteria in the gut protect against secondary bacterial infections in the lung [0.03%]
肠道中的分段丝状细菌可保护肺部免受继发性细菌感染
Alexandra Flemming
Alexandra Flemming
RNA-binding proteins and ribonucleoproteins as determinants of immunity [0.03%]
作为免疫决定因子的核糖核酸结合蛋白和核糖核蛋白
Martin Turner,Georg Petkau
Martin Turner
Infection triggers one of the most dramatic systemic responses in the body, and the coordinated activation and function of immune cells requires a dynamic regulation of transcriptomes and proteomes. This is achieved by RNA-binding proteins,...
Yvonne Bordon
Yvonne Bordon
Sensory neurons promote allergic sensitization and cross-sensitization via mTORC1 [0.03%]
感觉神经元通过mTORC1促进过敏和交叉过敏反应
Frederika Rentzeperis,Brian Kim
Frederika Rentzeperis
Metabolites as signalling molecules in the tumour immune microenvironment [0.03%]
肿瘤免疫微环境中的代谢产物作为信号分子
Youxiang Mao,Wenjun Xia,Peng Jiang
Youxiang Mao
Alterations in key metabolic pathways are required for tumour development and the adaptation of tumour cells to intrinsic or extrinsic stresses, as well as for the regulation of immune cell fate and immune responses in the tumour microenvir...