Lucy Bird
Lucy Bird
Mitochondria in monocyte-derived cells promote tissue damage in multiple sclerosis [0.03%]
单核细胞衍生细胞中的线粒体促进多发性硬化症中的组织损伤
Zi Yan Chen,Arthur Mortha
Zi Yan Chen
Matthew Jackson,Eileen E Parkes
Matthew Jackson
Katherine Whalley
Katherine Whalley
Integrating natural commensals and pathogens into preclinical mouse models [0.03%]
将天然共生菌和病原体整合入临床前小鼠模型中
Barbara Rehermann,Andrea L Graham,David Masopust et al.
Barbara Rehermann et al.
Fundamental discoveries in many aspects of mammalian physiology have been made using laboratory mice as research models. These studies have been facilitated by the genetic tractability and inbreeding of such mice, the large set of immunolog...
Heather D Hickman,Niki M Moutsopoulos
Heather D Hickman
Individual tissues have distinct antiviral properties garnered through various mechanisms, including physical characteristics, tissue-resident immune cells and commensal organisms. Although the oral mucosa has long been appreciated as a cri...
Xiaoshan Shi,Xing He,Chenqi Xu
Xiaoshan Shi
Immunoreceptors have crucial roles in sensing environmental signals and initiating immune responses to protect the host. Dysregulation of immunoreceptor signalling can therefore lead to a range of diseases, making immunoreceptor-based thera...
Guido Kroemer,Léa Montégut,Oliver Kepp et al.
Guido Kroemer et al.
The danger theory of immunity, introduced by Polly Matzinger in 1994, posits that tissue stress, damage or infection has a decisive role in determining immune responses. Since then, a growing body of evidence has supported the idea that the...
Herbert Tilg,Gianluca Ianiro,Antonio Gasbarrini et al.
Herbert Tilg et al.
Adipose tissue is an immunologically active organ that controls host physiology, partly through the release of mediators termed adipokines. In obesity, adipocytes and infiltrating leukocytes produce adipokines, which include the hormones ad...
Muzlifah Haniffa,Aidan Maartens,Elena Winheim et al.
Muzlifah Haniffa et al.
The human immune system is made up of a huge variety of cell types each with unique functions. Local networks of resident immune cells are poised to sense and protect against pathogen entry, whereas more widespread innate and adaptive immun...