Targets of protective immunity and opportunities in hepatitis C virus vaccine development [0.03%]
保护性免疫的作用目标及开发丙型肝炎疫苗的新策略
Seung Bum Park,Paul Zimmer-Harwood,T Jake Liang
Seung Bum Park
Hepatitis C virus (HCV) remains a serious global health burden that affects nearly 50 million people worldwide. Despite the availability of highly effective direct-acting antiviral drugs, the lack of an effective HCV vaccine hinders control...
Immune-related actinopathies at the cross-road of immunodeficiency, autoimmunity and autoinflammation [0.03%]
免疫缺陷、自身免疫和炎性自体免疫相交处的与免疫有关的肌动蛋白病
Loïc Dupré,Irinka Castanon,Kaan Boztug
Loïc Dupré
Actin cytoskeleton remodelling drives the migration of immune cells and their engagement in dynamic cell-cell contacts. The importance of actin cytoskeleton dynamics in immune cell function is highlighted by the discovery of inborn errors o...
Thomas Riffelmacher,Mitchell Kronenberg
Thomas Riffelmacher
Immunometabolism, the intersection of cellular metabolism and immune function, has revolutionized our understanding of T cell biology. Changes in cellular metabolism help guide the development of thymocytes and the transition of T cells fro...
Klaus Früh,Persephone Borrow,Geraldine M Gillespie et al.
Klaus Früh et al.
MHC-E is a highly conserved, non-polymorphic MHC protein that engages inhibitory and activating receptors on natural killer (NK) cells and T cells and can also present antigens to T cell receptors. NK cell responses driven by activating rec...
Yvonne Bordon
Yvonne Bordon
Lucy Bird
Lucy Bird
Kirsty Minton
Kirsty Minton
Ashraf Ul Kabir,Madhav Subramanian,Yoojung Kwon et al.
Ashraf Ul Kabir et al.
Immune checkpoint blockade therapy has revolutionized the treatment of metastatic and solid tumours, achieving durable responses in a subset of patients. However, most patients do not respond to immune checkpoint blockade, underscoring the ...
Defects in antigen processing and presentation: mechanisms, immune evasion and implications for cancer vaccine development [0.03%]
抗原加工和呈递缺陷：机制、免疫逃逸及对癌症疫苗开发的影响
Florian Huber,Michal Bassani-Sternberg
Florian Huber
Human tumour cells express mutated and non-mutated proteins that can be processed and presented by these cells as peptides bound to human leukocyte antigen (HLA). Some of these peptides are recognized by cognate T cell receptors as 'non-sel...
Fifty years of monoclonals: the past, present and future of antibody therapeutics [0.03%]
纪念单克隆抗体诞辰50周年：过去、现在和未来
Andrew C Chan,Greg D Martyn,Paul J Carter
Andrew C Chan
In 1975, Köhler and Milstein invented hybridoma technology for the generation of murine monoclonal antibodies with predetermined antigen-binding specificity. The transformative impact of monoclonal antibodies is demonstrated by their ubiqu...