Mariángeles Kovacs,Amaia Dominguez-Belloso,Samir Ali-Moussa et al.
Mariángeles Kovacs et al.
The peripheral immune system communicates with the brain through complex anatomical routes involving the skull, the brain borders, circumventricular organs and peripheral nerves. These immune-brain communication pathways were classically co...
Christian Kurts,Sibylle von Vietinghoff,Christian F Krebs et al.
Christian Kurts et al.
Kidney diseases are widespread and represent a considerable medical, social and economic burden. However, there has been marked progress in understanding the immunological aspects of kidney disease. This includes the identification of disti...
An inter-organ neuro-immuno-endocrine circuit for glucose homeostasis [0.03%]
一个调控葡萄糖稳态的器官间神经免疫内分泌回路
Kirsty Minton
Kirsty Minton
Srikanth Kodali,Caroline M Sands,Lei Guo et al.
Srikanth Kodali et al.
Fate decisions during immune cell development require temporally precise changes in gene expression. Evidence suggests that the dynamic modulation of these changes is associated with the formation of diverse, membrane-less nucleoprotein ass...
'Transcriptotype' explains phenotypic variability of inborn errors of immunity [0.03%]
“转录本型”解释了先天性免疫缺陷的表型变异
Alexandra Flemming
Alexandra Flemming
Alexandra Flemming
Alexandra Flemming
In vivo enhancement of tumour-specific T cells via peptide-MHC-pseudotyped retroviral gene delivery [0.03%]
通过肽-MHC假型逆转录病毒载体实现肿瘤特异性T细胞的体内基因修饰增强功能
Hugo Kwong,Persephone Borrow
Hugo Kwong
David G Russell,Nelson V Simwela,Joshua T Mattila et al.
David G Russell et al.
Macrophages are the primary host cell type for infection by Mycobacterium tuberculosis in vivo. Macrophages are also key immune effector cells that mediate the control of bacterial growth. However, the specific macrophage phenotypes that ar...
Regulation of cGAS-STING signalling and its diversity of cellular outcomes [0.03%]
cGAS-STING信号通路的调控及其多种细胞效应
Zhengyin Zhang,Conggang Zhang
Zhengyin Zhang
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signalling pathway, which recognizes both pathogen DNA and host-derived DNA, has emerged as a crucial component of the innate immune system, having important roles in...