Ana I Domingos
Ana I Domingos
Wendy S Garrett
Wendy S Garrett
Ari B Molofsky,Richard M Locksley
Ari B Molofsky
Kirsty Minton
Kirsty Minton
Kenneth Dorshkind,Thomas Höfer,Encarnacion Montecino-Rodriguez et al.
Kenneth Dorshkind et al.
Genetic defects that accumulate in haematopoietic stem cells (HSCs) are thought to be responsible for age-related changes in haematopoiesis that include a decline in lymphopoiesis and skewing towards the myeloid lineage. This HSC-centric vi...
John R Mascola,Anthony S Fauci
John R Mascola
Novel approaches to vaccine development include structure-based immunogen design, gene-based vaccine platforms and formulation of recombinant antigens with potent adjuvants. These technologies are producing encouraging results in the develo...
Yvonne Bordon
Yvonne Bordon
Yvonne Bordon
Yvonne Bordon
The gasdermins, a protein family executing cell death and inflammation [0.03%]
Gasdermin家族：执行细胞死亡和炎症的蛋白家族
Petr Broz,Pablo Pelegrín,Feng Shao
Petr Broz
The gasdermins are a family of recently identified pore-forming effector proteins that cause membrane permeabilization and pyroptosis, a lytic pro-inflammatory type of cell death. Gasdermins contain a cytotoxic N-terminal domain and a C-ter...
Yochai Wolf,Ana C Anderson,Vijay K Kuchroo
Yochai Wolf
T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), a member of the TIM family, was originally identified as a receptor expressed on interferon-γ-producing CD4+ and CD8+ T cells. Initial data indicated that TIM3 functioned ...