Investigation of ameliorative effects of indole-3 carbinol on TNBS-induced ulcerative colitis in rats [0.03%]
异硫氰酸酯改善TNBS诱导的大鼠溃疡性结肠炎的研究
Erkmen Tuğrul Epikmen,Emrah İpek,Mehmet Hesapçıoğlu et al.
Erkmen Tuğrul Epikmen et al.
Ulcerative colitis is a chronic inflammatory condition of the gastrointestinal tract that can predispose patients to colonic neoplasms. Various natural compounds have been explored for their therapeutic potential. Indole-3-carbinol (I3C), a...
Ameliorative role of curcumin and ascorbic acid on nephrotoxicity induced by environmentally relevant concentrations of different combinations of lead, fluoride and nitrate in albino rats [0.03%]
天然茋类化合物对高脂饮食小鼠的降糖作用及机制研究中文标题：姜黄素和抗坏血酸对环境相关浓度的铅、氟和硝酸盐不同组合诱导的大鼠肾毒性改善作用的研究
Chetanjyoti Tuteja,Navdeep Kaur
Chetanjyoti Tuteja
Groundwater pollution with lead, fluoride, and nitrate presents a growing environmental and health challenge. This study aimed to evaluate the nephrotoxic effects of these pollutants in male albino rats and assess the potential ameliorative...
Downregulation of acetyl-CoA carboxylase induces ferroptosis and inhibits tumor growth in oral squamous cell carcinoma [0.03%]
乙酰辅酶A羧化酶表达下调通过诱导铁死亡抑制口腔鳞状细胞癌的生长
Zhen Xu,Guodong Jia
Zhen Xu
In this study, we aimed to investigate the specific role of the acetyl-CoA carboxylase (ACACA) gene in oral squamous cell carcinoma (OSCC). We constructed the human tongue carcinoma cell line SAS with low ACACA expression and evaluated chan...
DAPI (4',6-diamidino-2-phenylindole) as a novel fluorochrome for amyloid staining that binds to β-pleated sheet [0.03%]
新型荧光染料DAPI的研制及用于β折叠丝状淀粉样蛋白的染色研究
Yu Uchida,Mao Mizukawa,Yumiko Kamiya et al.
Yu Uchida et al.
Amyloidosis is caused by the extracellular deposition of amyloid fibrils with a β-pleated sheet structure. Diagnosis typically relies on Congo red or Thioflavine T staining. Recently, DAPI (4',6-Diamidino-2-Phenylindole), which is a common...
7-Amino-4-methylcoumarin as a fluorescent substitute for Schiff's reagent in periodic acid-Schiff staining: Its application to in-resin correlative light-electron microscopy [0.03%]
7-氨基-4-甲基香豆素作为Schiff试剂在地衣酸希夫染色中的荧光替代品及其在树脂内相关光电子显微镜中的应用
Hiroshi Takase,Daisuke Hachisuka,Tomoya Sawano et al.
Hiroshi Takase et al.
Periodic acid-Schiff (PAS) staining is useful for visualizing glycogen and mucus. 7-amino-4-methylcoumarin (AMC), an organic reagent, exhibits blue fluorescent signals upon UV excitation. We recently showed that AMC can be used as a fluores...
Füsun Erhan Baycumendur,Elif Nur Tas Kepenek
Füsun Erhan Baycumendur
Safeguarding the integrity and functionality of the gastrointestinal system is paramount, given its vulnerability to several detrimental effects. One of the factors that can cause functional disorders is oxidative stress, which can disrupt ...
Microscopic and ultrastructural insights into the protective role of melatonin against tartrazine-induced hepatotoxicity [0.03%]
褪黑素对柠檬黄致肝毒性保护作用的显微和超微结构研究进展
Esraa M Hussein,Nora F Ghanem,Samaa M Bakr et al.
Esraa M Hussein et al.
Tartrazine, a coal tar-derived azo color, is utilized in food, drinks, cosmetics, and pharmaceuticals. Its azo group catabolizes in the gut, poisoning the liver. This study investigated the efficacy of melatonin, an endogenous antioxidant f...
Ivermectin-mediated GABAB receptor modulation ameliorates testicular torsion/detorsion-induced germ cell apoptosis and oxidative stress in rats [0.03%]
伊维菌素介导的GABAB受体调节改善了大鼠睾丸扭转/复位诱发的生精细胞凋亡和氧化应激反应
Atefe Solhjoo,Amirhossein Charmchi,Razieh Mohammad Jafari et al.
Atefe Solhjoo et al.
Testicular torsion, a medical condition contributing to male infertility, results in severe scrotal pain and ischemia. Oxidative stress factors contribute to germ cell death following surgical reperfusion, suggesting postoperative pharmacot...
Protective in vitro effects of Aloe vera on doxorubicin-induced ovarian toxicity in mice [0.03%]
芦荟对ドキソルubicin诱导的小鼠卵巢毒性具有体外保护作用
Ernando I T de Assis,Venância A N Azevedo,Miguel F De Lima Neto et al.
Ernando I T de Assis et al.
The present study investigated the protective effect of Aloe vera extract against the toxic effects of doxorubicin (DOX) on mice ovaries cultured in vitro. Female Swiss mice with regular estrous cycle were used. The animals (n = 48) had the...