Mesothelin in solid tumors: biology, biomarker utility, and therapeutic targeting [0.03%]
实体瘤中的间皮素：生物学特性、生物标志物价值和治疗靶向性
Ilary Ruscito,Elizaveta Baisheva,Eliane T Taube et al.
Ilary Ruscito et al.
Purpose of review: Mesothelin (MSLN) is a CA125-binding surface glycoprotein that mediates cell adhesion and peritoneal metastasis development in mesothelioma, high-grade serous ovarian cancer (HGSOC), pancreatic ductal a...
Victoria E Rodriguez,Miles Morrow,Rajeshree Rajpara et al.
Victoria E Rodriguez et al.
Purpose of review: Endometrial cancer is one of the few cancers that has continued to rise in incidence over the past decade, necessitating novel diagnostic and treatment approaches. ...
Alice Muzzarelli,Mariachiara Paderno,Domenica Lorusso
Alice Muzzarelli
Purpose of review: Cervical cancer remains the fourth most common cancer among women worldwide, predominantly affecting low- and middle-income countries because of limited access to human papillomavirus vaccination and sc...
Updates in palliative care of patients with gynecologic malignancies in 2026: early integration, resource models, and emerging therapies [0.03%]
2026年妇科恶性肿瘤姑息治疗进展：早期整合、资源模型和新兴疗法
Christopher Pietras,Teresa Khoo,Daniel Karlin
Christopher Pietras
Purpose of review: This review summarizes recent evidence in palliative care for patients with gynecologic malignancies, focusing on early integration, models of care delivery, and updates in symptom management and pallia...
Rojine T Ariani,Puja S Venkat
Rojine T Ariani
Purpose of review: Radiotherapy remains crucial to the management of gynecologic cancers. This review highlights recent advances in radiation delivery, integration with systemic therapies, and the evolving role of radioth...
Isabel Beshar,Lauren J Tostrud,Talayeh Ghezelayagh et al.
Isabel Beshar et al.
Purpose of review: There is limited data on contraceptive options in the setting of gynecologic and breast dysplasia. Despite this, many patients who report a history of these precancers retain their reproductive organs a...
Megan McCracken,Nichole Tyson
Megan McCracken
Purpose of review: Transgender and gender diverse (TGD) individuals assigned female at birth have specific contraceptive needs that are often unmet. This can be because of bias, systemic barriers, and misinformation as th...
Shaping the future of urogynecology through regenerative medicine [0.03%]
再生医学在女性泌尿生殖道功能障碍及盆底疾病防治中的作用展望
Tatyanna Henderson,Karen L Christman,Marianna Alperin
Tatyanna Henderson
Purpose of review: The etiology of urogynecologic conditions is multifactorial and complex. However, the inability of the host pelvic tissues to repair and regain their original function in response to various insults, in...
Multicompartment pelvic floor prolapse: advances in diagnosis and surgical management [0.03%]
多隔室盆腔脏器脱垂的诊断和手术治疗进展
Shannon L Wallace,Amy D Gee,Deepanjana Das
Shannon L Wallace
Purpose of review: Multicompartment pelvic organ prolapse, including concurrent rectal and vaginal prolapse, is increasingly recognized in aging populations. This review summarizes recent advances in diagnostic imaging, m...