Marieta P Theodorakopoulou,Fotini Iatridi,Pantelis A Sarafidis
Marieta P Theodorakopoulou
Purpose: Chronic kidney disease (CKD) is associated with elevated cardiovascular risk and progression to kidney failure, despite advances in therapy with renin-angiotensin system inhibitors and sodium-glucose-co-transport...
Washington A Freire-Filho,Maria Aparecida Dalboni,Rosilene M Elias
Washington A Freire-Filho
Purpose of review: Aging and chronic kidney disease mineral and bone disorder (CKD-MBD) interact to worsen bone health, vascular calcification, and frailty in older patients. The altered FGF23-Klotho axis and disrupted mi...
Sidar Copur,Alexandru Burlacu,Mehmet Kanbay
Sidar Copur
Purpose of review: The management of hypertension remains suboptimal despite the widespread use of multiple antihypertensive medication groups. We hereby aim to evaluate the novel therapeutic approaches for the management...
Glomerular filtration rate and sexual dimorphism: lessons from animal and human studies [0.03%]
glomerular filtration rate和性别二态性：来自动物与人类研究的启示
Elise Bouderlique,Romain Pszczolinski,Caroline Prot-Bertoye et al.
Elise Bouderlique et al.
Purpose of review: Integrating sex-based analyses is becoming a key point in the new recommendations, particularly in nephrology. Recent findings: ...
Sodium-glucose cotransporter 2 inhibitors: a novel approach to prevent the transition from acute kidney injury to chronic kidney disease [0.03%]
钠-葡萄糖共转运蛋白2抑制剂：预防急性肾损伤转为慢性肾脏病的新策略
Miguel Ángel Martínez-Rojas,Norma A Bobadilla
Miguel Ángel Martínez-Rojas
Purpose of review: Acute kidney injury (AKI) often progresses to chronic kidney disease (CKD), yet standardized clinical guidelines for managing this transition remain lacking. Recent studies suggest that sodium-glucose c...
Martin H de Borst
Martin H de Borst
Purpose of review: Diabetes is a major global health concern, affecting millions and increasing morbidity and mortality. Recent research highlights fibroblast growth factor 23 (FGF23) as a potential contributor to type 2 ...
Optimizing renin-angiotensin-aldosterone inhibition in advanced chronic kidney disease: balancing benefits and risks [0.03%]
慢性肾脏病进展期肾素血管紧张素醛固酮系统抑制的优化：权衡利弊
Sebastian Spencer,Sunil Bhandari
Sebastian Spencer
Purpose of review: Renin-angiotensin-aldosterone system inhibitors (RAASi), including angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARBs), are fundamental in chronic kidney disease ...
Fanny Bourdon,Belen Ponte,Anne Dufey Teso
Fanny Bourdon
Purpose of review: Hypertension is the most prevalent cardiovascular disease worldwide and the leading cause of mortality in both men and women. Despite well documented sex differences in prevalence, risk factors, and tre...
The role of osteopontin in chronic kidney disease-mineral bone disorder [0.03%]
骨基质蛋白在慢性肾病-钙磷代谢紊乱中的作用
Eduardo J Duque,Cecilia Giachelli,Rosa M A Moysés
Eduardo J Duque
Purpose of review: Chronic kidney disease-mineral bone disorder (CKD-MBD) is associated with several adverse outcomes, including bone fragility and sarcopenia. Identification of new agents mitigating systemic damage relat...
Ana Amaya-Garrido,Julie Klein
Ana Amaya-Garrido
Purpose of review: Vascular calcification significantly contributes to cardiovascular morbidity and mortality, particularly in high-risk populations like chronic kidney disease (CKD) patients. Calprotectin, a heterodimeri...