Yu Feng,Yanmiao Qi,Xiangjian Zheng
Yu Feng
Purpose of review: Kidney intercalated cells play critical roles in regulating body acid-base balance. We recently discovered Foxp1 and two downstream transcriptional factors Dmrt2 and Hmx2 are essential for intercalated ...
Editorial: One size does not fit all: moving toward individualized therapy [0.03%]
editorial：一人一方：迈向个体化治疗
Aline Martin,Rosa Moyses
Aline Martin
Impact of the choice of biomarkers and equations to estimate kidney function on the epidemiology of chronic kidney disease [0.03%]
选择生物标志物和估计肾功能的公式对慢性肾脏病流行病学的影响
Pierre Delanaye,Rouvick Mariano Gama,Thomas Stehlé
Pierre Delanaye
Purpose of review: The CKD-EPI equations were updated in 2021 to remove the race variable from eGFR estimation. In the same year, the creatinine-based EKFC equation was published, subsequently supplemented by the cystatin...
Momentum toward patient outcome trials in chronic kidney disease-mineral bone disorder [0.03%]
慢性肾脏病-矿物质骨病患者预后试验的发展趋势
Varsha Pothula Venkata,Julia J Scialla
Varsha Pothula Venkata
Purpose of review: The purpose of this review is to: evaluate the clinical trial evidence base for the treatment of chronic kidney disease mineral and bone disorder (CKD-MBD) in patients with kidney failure as it relates ...
Pascale Khairallah
Pascale Khairallah
Purpose of review: Fracture risk is significantly elevated in patients with chronic kidney disease (CKD), yet the diagnosis and treatment of CKD-associated osteoporosis remain complex. This review addresses the current ga...
Sarah Abu Kar,Raymond C Harris
Sarah Abu Kar
Purpose of review: This review highlights studies published in the last 18 months focusing on sex dimorphism in clinical and preclinical areas related to chronic kidney disease (CKD). ...
Calcium-binding protein 39 in with-no-lysine kinase signaling and the modulation of renal tubular transport [0.03%]
无丝氨酸/苏氨酸激酶WNK信号转导及肾小管转运调节中的钙结合蛋白39的作用
Mohammed Z Ferdaus,Eric Delpire
Mohammed Z Ferdaus
Purpose of review: The regulation of renal tubular transport is essential for maintaining electrolyte balance and blood pressure. Calcium-binding protein 39 (Cab39), also known as mouse protein-25 (MO25), plays a pivotal ...
Carsten Alexande Wagner,Daniela Egli-Spichtig,Isabel Rubio-Aliaga
Carsten Alexande Wagner
Purpose of review: The kidneys control systemic phosphate balance by regulating phosphate transporters mediating the reabsorption of inorganic phosphate (Pi). At least three different Na+-driven Pi cotransporters are loca...
Taewoo Lee,Lijun Ma,Barry I Freedman
Taewoo Lee
Purpose of review: The spectrum of kidney diseases caused by variation in the apolipoprotein L1 (APOL1) gene was identified in 2010 among patients with recent African ancestry. In the United States, inheriting two APOL1 r...